Discovery of Quinoline Analogues as Potent Antivirals against Enterovirus D68 (EV-D68)
Rami Musharrafieh,Jiantao Zhang,Peter Tuohy,Naoya Kitamura,Shreya S. Bellampalli,Yanmei Hu,Rajesh Khanna,Jun Wang +7 more
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TLDR
Three compounds 10a, 12a, and 12c were identified to have significantly improved potency and a high selectivity index compared with dibucaine against five different strains of EV-D68 viruses, suggesting they might be further developed for the treatment of both respiratory infection as well as neuronal infection.Abstract:
Enterovirus D68 (EV-D68) is an atypical nonpolio enterovirus that mainly infects the respiratory system of humans, leading to moderate-to-severe respiratory diseases. In rare cases, EV-D68 can spre...read more
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Acute flaccid myelitis: cause, diagnosis, and management.
Olwen C. Murphy,Kevin Messacar,Leslie Benson,Riley Bove,Jessica L. Carpenter,Thomas O. Crawford,Janet Dean,Roberta L. DeBiasi,Jay Desai,Matthew J. Elrick,Raquel Farias-Moeller,Grace Y. Gombolay,Benjamin Greenberg,Matthew Harmelink,Sue Hong,Sarah Hopkins,Joyce Oleszek,Catherine Otten,Cristina L. Sadowsky,Cristina L. Sadowsky,Teri Schreiner,Kiran T. Thakur,Keith Van Haren,Carolina M Carballo,Pin Fee Chong,Amary Fall,Vykuntaraju K Gowda,Jelte Helfferich,Ryutaro Kira,Ming K. Lim,Eduardo Lopez,Elizabeth Wells,E. Ann Yeh,Carlos A. Pardo,Andrea Salazar-Camelo,Divakar Mithal,Molly Wilson-Murphy,Andrea Bauer,Colyn Watkins,Mark J. Abzug,Samuel R. Dominguez,Craig A. Press,Michele L. Yang,Nusrat Ahsan,Leigh Ramos-Platt,Emmanuelle Tiongson,Mitchel Seruya,Ann Tilton,Elana Katz,Matthew P. Kirschen,Apurva Shah,Erlinda Ulloa,Sabrina Yum,Lileth Mondok,Megan Blaufuss,Amy B. Rosenfeld,Wendy Vargas,Jason Zucker,Anusha K. Yeshokumar,Allison Navis,Kristen Chao,Kaitlin Hagen,Michelle Melicosta,Courtney Porter,Margaret Tunney,Richard H. Scheuermann,Priya Duggal,Andrew Pekosz,Amy Bayliss,Meghan Moore,Allan Belzberg,Melania Bembea,Caitlin O'Brien,Rebecca Riggs,Jessica Nance,Aaron M. Milstone,Jessica Rice,Maria A. Garcia-Dominguez,Eoin P. Flanagan,Jan Mendelt Tillema,Glendaliz Bosques,Sonal Bhatia,Eliza Gordon-Lipkin,Dawn Deike,Gadi Revivo,Dan Zlotolow,Gabrielle deFiebre,Peggy Lazerow,Timothy Lotze,Ari Bitnun,Kristen Davidge,Jiri Vajsar,Amy Moore,Chamindra Konersman,Kendall B. Nash,Jonathan B. Strober,Nalin Gupta,Charles Y. Chiu,Michael O. Sweeney,William Jackson,Dennis W. Simon,Kavita Thakkar,Jonathan D. Cheng,John Luce,S. K. Das,Matthew Vogt,NgocHanh Vu,Jacqueline S. Gofshteyn,Naila Makhani,Payal Patel +109 more
TL;DR: In this article, the authors describe the epidemiology, clinical features, course, and outcomes of acute flaccid myelitis to help to guide diagnosis, management, and rehabilitation, and further studies evaluating host and pathogen factors, including investigations into genetic, viral, and immunological features of affected patients, host-virus interactions, and investigations of targeted therapeutic approaches to improve the long-term outcomes in this population.
Journal ArticleDOI
Synthetic and medicinal perspective of quinolines as antiviral agents.
Ramandeep Kaur,Kapil Kumar +1 more
TL;DR: The role of quinoline derivatives as antiviral agent has been discussed in this paper, where the authors have made an attempt to describe recent synthetic protocols developed by various research groups.
Journal ArticleDOI
Enterovirus A71 antivirals: Past, present, and future
TL;DR: Major discoveries in EV-A71 antiviral development are discussed, the advantages and limitations of each drug target are analyzed, and the knowledge gaps that need to be addressed are highlighted to advance the field forward.
Journal ArticleDOI
Identification of dibucaine derivatives as novel potent enterovirus 2C helicase inhibitors: In vitro, in vivo, and combination therapy study.
Qi Tang,Xu Zhichao,Mengyu Jin,Ting Shu,Yinuo Chen,Leilei Feng,Qiuhan Zhang,Ke Lan,Shuwen Wu,Hai-Bing Zhou +9 more
TL;DR: Mechanism study indicated that compound 6i inhibited EV-A71 via targeting 2C helicase, thus impeding RNA remodeling and metabolism, and data indicated that 6i is a promising EV- A71 inhibitor and worth extensive preclinical investigation as a lead compound.
Journal ArticleDOI
Enterovirus A71 antivirals: Past, present, and future
TL;DR: A recent review as discussed by the authors discusses major discoveries in EV-A71 antiviral development, analyzes the advantages and limitations of each drug target, and highlights the knowledge gaps that need to be addressed to advance the field forward.
References
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A novel outbreak enterovirus D68 strain associated with acute flaccid myelitis cases in the USA (2012–14): a retrospective cohort study
Alexander L. Greninger,Samia N. Naccache,Kevin Messacar,Anna Clayton,Guixia Yu,Sneha Somasekar,Scot Federman,Doug Stryke,Christopher Anderson,Shigeo Yagi,Sharon Messenger,Debra A. Wadford,Dongxiang Xia,James Watt,Keith Van Haren,Samuel R. Dominguez,Carol A. Glaser,Grace M. Aldrovandi,Charles Y. Chiu +18 more
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Suppression of inflammatory and neuropathic pain by uncoupling CRMP-2 from the presynaptic Ca2+ channel complex
Joel M. Brittain,Djane B. Duarte,Sarah M. Wilson,Weiguo Zhu,Carrie J. Ballard,Philip L. Johnson,Nai-Kui Liu,Wenhui Xiong,Matthew S. Ripsch,Yuying Wang,Jill C. Fehrenbacher,Stephanie D. Fitz,May Khanna,Chul Park,Brian S. Schmutzler,Bo M. Cheon,Michael R. Due,Tatiana Brustovetsky,Nicole M. Ashpole,Andy Hudmon,Samy O. Meroueh,Cynthia M. Hingtgen,Nickolay Brustovetsky,Ru-Rong Ji,Joyce H. Hurley,Xiaoming Jin,Anantha Shekhar,Xiao Ming Xu,Gerry Stephen Oxford,Michael R. Vasko,Fletcher A. White,Rajesh Khanna +31 more
TL;DR: By preventing CRMP-2–mediated enhancement of CaV2.2 function, TAT-CBD3 alleviated inflammatory and neuropathic hypersensitivity, an approach that may prove useful in managing chronic pain.