Dogs are more permissive than cats or guinea pigs to experimental infection with a human isolate of Bartonella rochalimae.
Bruno B Chomel,Jennifer B. Henn,Rickie W. Kasten,Nathan C. Nieto,Janet E Foley,Sophia Papageorgiou,Claire Allen,Jane E. Koehler +7 more
TLDR
It is suggested that dogs could be a reservoir of this strain of B. rochalimae, in contrast to cats and guinea pigs, that was first isolated from the blood of a human who traveled to Peru and was exposed to multiple insect bites.Abstract:
Bartonella rochalimae was first isolated from the blood of a human who traveled to Peru and was exposed to multiple insect bites. Foxes and dogs are likely natural reservoirs for this bacterium. We report the results of experimental inoculation of two dogs, five cats and six guinea pigs with the only human isolate of this new Bartonella species. Both dogs became bacteremic for 5-7 weeks, with a peak of 10 3 -10 4 colony forming units (CFU)/mL blood. Three cats had low bacteremia levels (< 200 CFU/mL) of 6-8 weeks' duration. One cat that remained seronegative had two bacterial colonies isolated at a single culture time point. A fifth cat never became bacteremic, but seroconverted. None of the guinea pigs became bacteremic, but five seroconverted. These results suggest that dogs could be a reservoir of this strain of B. rochalimae, in contrast to cats and guinea pigs. Bartonella rochalimae / dogs / cats / guinea pigs / zoonosisread more
Citations
More filters
Journal ArticleDOI
Intruders below the Radar: Molecular Pathogenesis of Bartonella spp.
Alexander Harms,Christoph Dehio +1 more
TL;DR: Current knowledge on the molecular processes underlying both the infection strategy and pathogenesis of Bartonella are compiled and their connection to the clinical presentation of human patients is discussed, which ranges from minor complaints to life-threatening disease.
Journal ArticleDOI
The Trw Type IV Secretion System of Bartonella Mediates Host-Specific Adhesion to Erythrocytes
Muriel Vayssier-Taussat,Danielle Le Rhun,Hong Kuan Deng,Francis Biville,Sandra Cescau,Antoine Danchin,Geneviève Marignac,Evelyne Lenaour,Henri Jean Boulouis,Maria Mavris,Lionel Arnaud,Huanming Yang,Jing Wang,Maxime Québatte,Philipp Engel,Henri L Saenz,Christoph Dehio +16 more
TL;DR: It is shown that the laterally acquired Trw T4SS diversified in the Bartonella lineage to facilitate host-restricted adhesion to erythrocytes in a wide range of mammals.
Journal ArticleDOI
Parallel Evolution of a Type IV Secretion System in Radiating Lineages of the Host-Restricted Bacterial Pathogen Bartonella
Philipp Engel,Walter Salzburger,Marius Liesch,Chao-Chin Chang,Soichi Maruyama,Christa Lanz,Alexandra Calteau,Aurélie Lajus,Claudine Médigue,Stephan C. Schuster,Christoph Dehio +10 more
TL;DR: The parallel molecular evolution of the VirB/Bep system displays a striking example of a key innovation involved in independent adaptive processes and the emergence of bacterial pathogens, highlighting the remarkable evolvability of T4SSs and their effector proteins, explaining their broad application in bacterial interactions with the environment.
Journal ArticleDOI
Persistence of Bartonella spp. stealth pathogens: from subclinical infections to vasoproliferative tumor formation
TL;DR: The ability of Bartonella spp.
Journal ArticleDOI
Bartonella infections in cats and dogs including zoonotic aspects
TL;DR: An update and European perspective on Bartonella infections in cats and dogs, including clinical, diagnostic, epidemiological, pathological, treatment and zoonotic aspects is provided.
References
More filters
Journal ArticleDOI
A prospective study of canine infective endocarditis in northern California (1999-2001): emergence of Bartonella as a prevalent etiologic agent.
Kristin A. MacDonald,Bruno B Chomel,Mark D Kittleson,Rick W. Kasten,William P. Thomas,Patricia A. Pesavento +5 more
TL;DR: Bartonella is a common cause of infective endocarditis in dogs of northern California and a high Bartonella serologic titer (> 1:512) is useful antemortem to diagnose aortic valve IE due to Bartoneella.
Journal ArticleDOI
Bartonella spp. isolated from wild and domestic ruminants in North America.
Chao Chin Chang,Bruno B Chomel,Rickie W. Kasten,R. Heller,Katherine M. Kocan,Hiroshi Ueno,Kazuhiro Yamamoto,Vernon C. Bleich,Becky M. Pierce,Ben J. Gonzales,Pamela K. Swift,Walter M. Boyce,Spencer S. Jang,Henri Jean Boulouis,Yves Piémont +14 more
TL;DR: Findings indicate potential for inter- and intraspecies transmission among ruminants, as well as risk that these Bartonella spp.
Journal ArticleDOI
Aortic Valve Endocarditis in a Dog Due to Bartonella clarridgeiae
Bruno B Chomel,Kristin A. Mac Donald,Rickie W. Kasten,C. C. Chang,Aaron C. Wey,Janet E Foley,William P. Thomas,Mark D Kittleson +7 more
TL;DR: It is reported the first documented case of endocarditis associated with Bartonella clarridgeiae in any species, diagnosed in a 2.5-year-old male neutered boxer with acute third-degree atrioventricular block and died of cardiopulmonary arrest prior to pacemaker implantation.
Journal ArticleDOI
Gray Foxes (Urocyon cinereoargenteus) as a Potential Reservoir of a Bartonella clarridgeiae-Like Bacterium and Domestic Dogs as Part of a Sentinel System for Surveillance of Zoonotic Arthropod-Borne Pathogens in Northern California
Jennifer B. Henn,Jennifer B. Henn,Mourad W. Gabriel,Mourad W. Gabriel,Rickie W. Kasten,Richard N. Brown,Jerold H. Theis,Janet E Foley,Bruno B Chomel +8 more
TL;DR: The high prevalence of bacteremia and seroreactivity to Bartonella spp.
Journal ArticleDOI
Seroprevalence of antibodies against Bartonella species and evaluation of risk factors and clinical signs associated with seropositivity in dogs.
Jennifer B. Henn,Chu Hao Liu,Chu Hao Liu,Rick W. Kasten,Brian A. Vanhorn,Brian A. Vanhorn,Laurel A. Beckett,Philip H. Kass,Bruno B Chomel +8 more
TL;DR: Bartonella infection should be considered in dogs with clinical signs of lameness, arthritis-related lameness or nasal discharge or epistaxis, or splenomegaly, and Breed appeared to be an important risk factor for seropositivity.