Drugs that target dynamic microtubules: a new molecular perspective.
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TLDR
The effects of microtubule‐binding chemotherapeutic agents are reviewed from a new perspective, considering how their mode of binding induces conformational changes and alters biological function relative to the molecular vectors of micro Tubule assembly or disassembly.Abstract:
Microtubules have long been considered an ideal target for anticancer drugs because of the essential role they play in mitosis, forming the dynamic spindle apparatus. As such, there is a wide variety of compounds currently in clinical use and in development that act as antimitotic agents by altering microtubule dynamics. Although these diverse molecules are known to affect microtubule dynamics upon binding to one of the three established drug domains (taxane, vinca alkaloid, or colchicine site), the exact mechanism by which each drug works is still an area of intense speculation and research. In this study, we review the effects of microtubule-binding chemotherapeutic agents from a new perspective, considering how their mode of binding induces conformational changes and alters biological function relative to the molecular vectors of microtubule assembly or disassembly. These “biological vectors” can thus be used as a spatiotemporal context to describe molecular mechanisms by which microtubule-targeting drugs work.read more
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References
More filters
Journal ArticleDOI
Vascular targeting agents enhance chemotherapeutic agent activities in solid tumor therapy
TL;DR: The inclusion of the antivascular agents did not increase bone marrow stem cell toxicity associated with these anticancer drugs, thus giving rise to a therapeutic gain, and enhanced cisplatin efficacy was dependent on the sequence and interval between the agents.
Journal ArticleDOI
Regulation of microtubule dynamic instability.
TL;DR: The current knowledge about proteins that modulate MT dynamic instability is reviewed, finding that a clear picture of how individual factors affect the MT structure is emerging.
Journal Article
Induction of Apoptosis in Proliferating Human Endothelial Cells by the Tumor-specific Antiangiogenesis Agent Combretastatin A-4
TL;DR: The results indicate that the selective cytotoxic effect of combretastatin A-4 is mediated by the induction of apoptosis rather than by necrosis and may provide an enhanced clinical strategy in cancer chemotherapy with this new agent.
Journal ArticleDOI
Microtubule-interacting drugs for cancer treatment.
TL;DR: The search for new tubulin-binding drugs is both important and promising for the therapeutic options for the management of cancer as well as effective chemotherapeutic agents in drug-resistant cell lines.
Journal ArticleDOI
Structural mechanisms underlying nucleotide-dependent self-assembly of tubulin and its relatives.
Eva Nogales,Hong-Wei Wang +1 more
TL;DR: A two-state mechanism has been proposed for the recycling of alphabeta-tubulin during the microtubule disassembly-assembly cycle; this mechanism may be unique to eukaryotic dimeric tubulin and the micro Tubulin structure.
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