Drugs that target dynamic microtubules: a new molecular perspective.
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TLDR
The effects of microtubule‐binding chemotherapeutic agents are reviewed from a new perspective, considering how their mode of binding induces conformational changes and alters biological function relative to the molecular vectors of micro Tubule assembly or disassembly.Abstract:
Microtubules have long been considered an ideal target for anticancer drugs because of the essential role they play in mitosis, forming the dynamic spindle apparatus. As such, there is a wide variety of compounds currently in clinical use and in development that act as antimitotic agents by altering microtubule dynamics. Although these diverse molecules are known to affect microtubule dynamics upon binding to one of the three established drug domains (taxane, vinca alkaloid, or colchicine site), the exact mechanism by which each drug works is still an area of intense speculation and research. In this study, we review the effects of microtubule-binding chemotherapeutic agents from a new perspective, considering how their mode of binding induces conformational changes and alters biological function relative to the molecular vectors of microtubule assembly or disassembly. These “biological vectors” can thus be used as a spatiotemporal context to describe molecular mechanisms by which microtubule-targeting drugs work.read more
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References
More filters
Journal ArticleDOI
Tubulin dynamics in cultured mammalian cells.
TL;DR: The fibrous, fluorescence patterns that developed in the microinjected cells were almost indistinguishable from the pattern of microtubules seen in the same cells by indirect immunofluorescence, and mean half times of redistribution were 18-fold shorter in mitotic cells than they were in interphase cells.
Journal ArticleDOI
Microtubules, microtubule-interfering agents and apoptosis
TL;DR: Sustained modification of signaling routes and changes in the scaffolding properties of microtubules seem to constitute two major processes in the apoptotic response induced by microtubule-interfering agents.
Journal ArticleDOI
Structure and utilization of tubulin isotypes.
TL;DR: The tubulin hypothesis tested, six isotype classes encoded by orthologous gene families in birds and mammals, and regulatory compartments for tubulin synthesis are revealed.
Journal Article
BMS-247550: a novel epothilone analog with a mode of action similar to paclitaxel but possessing superior antitumor efficacy.
Francis Y. Lee,Robert M. Borzilleri,Craig R. Fairchild,Soong-Hoon Kim,Byron H. Long,Carmen Reventos-Suarez,Gregory D. Vite,William C. Rose,Robert A. Kramer +8 more
TL;DR: Efficacy data demonstrate that BMS-247550 has the potential to surpass Taxol in both clinical efficacy and ease of use (i.e., less frequent treatment schedule and/or oral administration).
Journal ArticleDOI
Yeast kinesin-8 depolymerizes microtubules in a length-dependent manner
TL;DR: It is directly demonstrated that Kip3p destabilizes microtubules by depolymerizing them — accounting for the effects of kinesin-8 perturbations on microtubule and spindle length observed in fungi and metazoan cells.
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