Early intervention with ABA prevents neuroinflammation and memory impairment in a triple transgenic mice model of Alzheimer´s disease.
Verónica Espinosa-Fernández,Aroa Mañas-Ojeda,Mar Pacheco-Herrero,Ernestina Castro-Salazar,Francisco Ros-Bernal,Ana María Sánchez-Pérez +5 more
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TLDR
It is shown that phytohormone Abscisic Acid, can prevent memory impairment and neuroinflammation markers in a triple transgenic mouse model, where no peripheral inflammatory changes have occurred.About:
This article is published in Behavioural Brain Research.The article was published on 2019-11-18 and is currently open access. It has received 12 citations till now. The article focuses on the topics: Neuroinflammation & Cognitive decline.read more
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Can We Treat Neuroinflammation in Alzheimer's Disease?
Sandra Sánchez-Sarasúa,Iván Fernández-Pérez,Verónica Espinosa-Fernández,Ana María Sánchez-Pérez,Juan Carlos Ledesma +4 more
TL;DR: This review highlights the importance of a broad multimodal approach to treat successfully the neuroinflammation underlying AD and introduces new players underlying neuro inflammation in AD: the activity of the endocannabinoid system and the intestinal microbiota as neuroprotectors.
Journal ArticleDOI
Phytohormones: Multifunctional nutraceuticals against metabolic syndrome and comorbid diseases
TL;DR: How bioactive phytohormones can be generated endogenously and through the gut microbiome and subsequently influence immune responses and metabolism is introduced.
Journal ArticleDOI
Phytohormone Abscisic Acid Improves Memory Impairment and Reduces Neuroinflammation in 5xFAD Mice by Upregulation of LanC-Like Protein 2.
TL;DR: Results indicate that ABA reduced Aβ deposition, neuroinflammation, and memory impairment, which is the most characteristic pathology of AD, via the upregulation of LanC-like protein 2, known as a receptor of ABA.
Journal ArticleDOI
Abscisic acid, a promising therapeutic molecule to prevent Alzheimer's and neurodegenerative diseases.
TL;DR: It is proved that early intervention significantly augments the probability of preventing cognitive impairment, and ABA could be considered as a new therapeutic molecule preventing neurodegenerative diseases.
Journal ArticleDOI
Long Non-Coding RNAs, Extracellular Vesicles and Inflammation in Alzheimer’s Disease
Ania Canseco-Rodriguez,Valeria Masola,Vincenza Aliperti,María Meseguer-Beltrán,Aldo Donizetti,Ana María Sánchez-Pérez +5 more
TL;DR: In this article , the role of long non-coding RNA (lncRNA) in neurodegenerative diseases has been explored, focusing on lncRNAs and inflammation in the context of AD.
References
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Journal ArticleDOI
Resting Microglial Cells Are Highly Dynamic Surveillants of Brain Parenchyma in Vivo
TL;DR: Using in vivo two-photon imaging in neocortex, it is found that microglial cells are highly active in their presumed resting state, continually surveying their microenvironment with extremely motile processes and protrusions.
Journal ArticleDOI
Neuroinflammation in Alzheimer's disease
Michael T. Heneka,Monica J. Carson,Joseph El Khoury,Gary E. Landreth,Frederic Brosseron,Douglas L. Feinstein,Andreas H. Jacobs,Tony Wyss-Coray,Tony Wyss-Coray,Javier Vitorica,Richard M. Ransohoff,Karl Herrup,Sally A. Frautschy,Bente Finsen,Guy C. Brown,Alexei Verkhratsky,Alexei Verkhratsky,Alexei Verkhratsky,Koji Yamanaka,Jari Koistinaho,Eicke Latz,Eicke Latz,Annett Halle,Gabor C. Petzold,Terrence Town,Dave Morgan,Mari L. Shinohara,V. Hugh Perry,Clive Holmes,Clive Holmes,Nicolas G. Bazan,David J. Brooks,Stéphane Hunot,Bertrand Joseph,Nikolaus Deigendesch,Olga Garaschuk,Erik Boddeke,Charles A. Dinarello,John C.S. Breitner,Greg M. Cole,Douglas T. Golenbock,Markus P. Kummer +41 more
TL;DR: Genome-wide analysis suggests that several genes that increase the risk for sporadic Alzheimer's disease encode factors that regulate glial clearance of misfolded proteins and the inflammatory reaction.
Journal ArticleDOI
Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus.
TL;DR: It is demonstrated that voluntary exercise is sufficient for enhanced neurogenesis in the adult mouse dentate gyrus, in amounts similar to enrichment conditions.
Journal ArticleDOI
Inflammation in CNS neurodegenerative diseases.
TL;DR: A better understanding of neuroimmune interactions during development and disease will be key to further manipulating these responses and the development of effective therapies to improve quality of life, and reduce the impact of neuroinflammatory and degenerative diseases.
Journal ArticleDOI
Cellular forms and functions of brain microglia.
TL;DR: In their role as tissue macrophages, microglia are involved in immune responses, tissue transplantation, and AIDS dementia complex, as well as many other neurological mechanisms and diseases.
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