Effect of pravastatin on cardiovascular events in women after myocardial infarction: the Cholesterol and Recurrent Events (CARE) trial
Sandra J. Lewis,Frank M. Sacks,Jayne Mitchell,Cara East,Stephen P. Glasser,Sheren Kell,Rebecca Letterer,Marian C. Limacher,Lemuel A. Moyé,Jean L. Rouleau,Marc A. Pfeffer,Eugene Braunwald +11 more
TLDR
Pravastatin led to significant early reduction of a wide range of cardiovascular events in post-MI women with average cholesterol levels and improved plasma lipids similarly in men and women.About:
This article is published in Journal of the American College of Cardiology.The article was published on 1998-07-01 and is currently open access. It has received 225 citations till now. The article focuses on the topics: Pravastatin & Myocardial infarction.read more
Citations
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Journal ArticleDOI
Effect of statins on risk of coronary disease: a meta-analysis of randomized controlled trials.
TL;DR: The meta-analysis indicates that reduction in LDL-C associated with statin drug treatment decreases the risk of coronary heart disease and all-cause mortality.
Journal ArticleDOI
National Lipid Association Recommendations for Patient-Centered Management of Dyslipidemia: Part 2.
Terry A. Jacobson,Kevin C. Maki,Carl E. Orringer,Peter B. Jones,Penny M. Kris-Etherton,Geeta Sikand,Ralph La Forge,Stephen R. Daniels,Don P. Wilson,Pamela B. Morris,Robert A. Wild,Scott M. Grundy,Martha L. Daviglus,Keith C. Ferdinand,Krishnaswami Vijayaraghavan,Prakash Deedwania,Judith A. Aberg,Katherine P. Liao,James M. McKenney,Joyce L. Ross,Lynne T. Braun,Matthew K. Ito,Harold E. Bays,W. Virgil Brown +23 more
TL;DR: This document represents a continuation of the National Lipid Association recommendations developed by a diverse panel of experts who examined the evidence base and provided recommendations regarding the following topics: lifestyle therapies and strategies to improve patient outcomes by increasing adherence and using team-based collaborative care.
Journal ArticleDOI
The evolving role of statins in the management of atherosclerosis.
TL;DR: Clinical and experimental evidence indicates that the beneficial actions of statins occur rapidly and yield potentially clinically important anti-ischemic effects as early as one month after commencement of therapy.
Journal ArticleDOI
A comprehensive view of sex-specific issues related to cardiovascular disease
Louise Pilote,Kaberi Dasgupta,Veena Guru,Karin H. Humphries,Jennifer J. McGrath,Colleen M. Norris,Doreen M. Rabi,Johanne Tremblay,Arsham Alamian,Tracie A. Barnett,Jafna L. Cox,William A. Ghali,Sherry L. Grace,Pavel Hamet,Teresa Ho,Susan Kirkland,Marie Lambert,Danielle Libersan,Jennifer O'Loughlin,Gilles Paradis,Milan Petrovich,Vicky Tagalakis +21 more
TL;DR: The lack of good trial evidence concerning sex-specific outcomes has led to assumptions about CVD treatment in women, which may have resulted in inadequate diagnoses and suboptimal management, greatly affecting outcomes, and may also explain why cardiovascular health in women is not improving as fast as that of men.
Journal ArticleDOI
Preventing myocardial infarction in the young adult in the first place: how do the national cholesterol education panel iii guidelines perform?
TL;DR: The new National Cholesterol Education Program (NCEP) III guidelines offer multiple new features but have a tendency to underappreciate the risk for disease in young adults.
References
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Book ChapterDOI
Nonparametric Estimation from Incomplete Observations
Edward L. Kaplan,Paul Meier +1 more
TL;DR: In this article, the product-limit (PL) estimator was proposed to estimate the proportion of items in the population whose lifetimes would exceed t (in the absence of such losses), without making any assumption about the form of the function P(t).
Journal ArticleDOI
Executive Summary of the Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III)
Scott M. Grundy,David W. Bilheimer,Alan Chait,Luther T. Clark,Margo A. Denke,Richard J. Havel,William R. Hazzard,Stephen B. Hulley,Donald B. Hunninghake,Robert A. Kreisberg,Penny M. Kris-Etherton,James M. McKenney,Michael A. Newman,Ernst J. Schaefer,Burton E. Sobel,Carolyn Somelofski,Milton C. Weinstein,H. Bryan Brewer,James I. Cleeman,Karen A. Donato,Nancy D. Ernst,Jeffrey M. Hoeg,Basil M. Rifkind,Jacques E. Rossouw,Christopher T. Sempos,Joanne M. Gallivan,Maureen N. Harris,Laurie Quint-Adler +27 more
TL;DR: Dairy therapy remains the first line of treatment of high blood cholesterol, and drug therapy is reserved for patients who are considered to be at high risk for CHD, and the fundamental approach to treatment is comparable.
Journal ArticleDOI
The Effect of Pravastatin on Coronary Events after Myocardial Infarction in Patients with Average Cholesterol Levels
Frank M. Sacks,Marc A. Pfeffer,Lemuel A. Moyé,Jean L. Rouleau,John D. Rutherford,Thomas G. Cole,Lisa E. Brown,J. W. Warnica,J. M. O. Arnold,Chuan Chuan C Wun,Barry R. Davis,Eugene Braunwald +11 more
TL;DR: It is demonstrated that the benefit of cholesterol-lowering therapy extends to the majority of patients with coronary disease who have average cholesterol levels and was also greater in patients with higher pretreatment levels of LDL cholesterol.
Journal ArticleDOI
Report of the National Cholesterol Education Program Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults
DeWitt S. Goodman,Stephen B. Hulley,Luther T. Clark,Clay Davis,Valentin Fuster,John C. LaRosa,Albert Oberman,Ernst J. Schaefer,Daniel Steinberg,W. Virgil Brown,Scott M. Grundy,Diane M. Becker,Edwin L. Bierman,Jacqueline Sooter-Bochenek,Rebecca M. Mullis,Neil J. Stone,Donald B. Hunninghake,Jacqueline M. Dunbar,Henry N. Ginsberg,D. Roger Illingworth,Harold C. Sadin,Gustav Schonfeld,James I. Cleeman,H. Bryan Brewer,Nancy D. Ernst,William T. Friedewald,Jeffrey M. Hoeg,Basil M. Rifkind,David L. Gordon +28 more
TL;DR: New guidelines for the treatment of high blood cholesterol in adults 20 years of age and over are provided and which patients should go on to have lipoprotein analysis, and which should receive cholesterol-lowering treatment on the basis of their low density lipop protein levels and status with respect to other coronary heart disease risk factors are detailed.
Journal ArticleDOI
Coronary Risk Factors and Plaque Morphology in Men with Coronary Disease Who Died Suddenly
TL;DR: Among men with coronary disease who die suddenly, abnormal serum cholesterol concentrations - particularly elevated ratios of total cholesterol to HDL cholesterol - predispose patients to rupture of vulnerable plaques, whereas cigarette smoking predisposes patients to acute thrombosis.
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