Effects of carbon dioxide/bicarbonate on induction of DNA single-strand breaks and formation of 8-nitroguanine, 8-oxoguanine and base-propenal mediated by peroxynitrite
TLDR
It is found that bicarbonate caused a dose‐dependent increase of up to 6‐fold in the formation of 8‐nitroguanine in calf‐thymus DNA incubated with 0.1 mM peroxynitrite, whereas it produced no apparent effect on 8‐oxoguanine formation.About:
This article is published in FEBS Letters.The article was published on 1996-12-09 and is currently open access. It has received 169 citations till now. The article focuses on the topics: Peroxynitrite & Peroxynitrous acid.read more
Citations
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Journal ArticleDOI
The Role of Oxidative Stress in Carcinogenesis
TL;DR: This review examines the evidence of cellular oxidants' involvement in the carcinogenesis process, and focuses on the mechanisms for production, cellular damage produced, and the role of signaling cascades by reactive oxygen species.
Journal ArticleDOI
Unraveling peroxynitrite formation in biological systems.
TL;DR: This review provides the conceptual framework and a comprehensive analysis of the current experimental strategies that can serve to unequivocally define the existence and quantitation of peroxynitrite in biological systems of different levels of organization and complexity.
Journal ArticleDOI
Reactive nitrogen species in the chemical biology of inflammation.
TL;DR: This review will focus on recent advances in understanding of the protein and DNA damage caused by reactive nitrogen species produced by macrophages and neutrophils, with emphasis on nitric oxide, nitrous anhydride, peroxynitrite, and nitrogen dioxide radical.
Journal ArticleDOI
The chemistry of DNA damage from nitric oxide and peroxynitrite
TL;DR: This review describes the different mechanisms by which nitric oxide can damage DNA and outlines the mechanisms underlying DNA damage induced by nitrous anhydride and peroxynitrite.
Journal ArticleDOI
Nitrogen dioxide and carbonate radical anion: two emerging radicals in biology.
Ohara Augusto,Marcelo G. Bonini,Angélica M. Amanso,Edlaine Linares,Célio C.X. Santos,Silvia Lopes de Menezes +5 more
TL;DR: A framework for this hypothesis is provided and the potential sources and properties of these radicals that are likely to become increasingly recognized as important mediators of biological processes are discussed.
References
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Peroxynitrite oxidation of sulfhydryls. The cytotoxic potential of superoxide and nitric oxide.
TL;DR: Peroxynitrite anion was a less effective thiol-oxidizing agent than its anion, with oxidation presumably mediated by the decomposition products, hydroxyl radical and nitrogen dioxide.
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Peroxynitrite-induced membrane lipid peroxidation : the cytotoxic potential of superoxide and nitric oxide
TL;DR: It is concluded that the conjugate acid of peroxynitrite, peroxlynitrous acid (ONOOH), and/or its decomposition products, i.e., .OH and nitrogen dioxide (.NO2), initiate lipid peroxidation without the requirement of iron.
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Peroxynitrite, a cloaked oxidant formed by nitric oxide and superoxide.
TL;DR: In theory, activation could involve (1) heterolysis to OH- and NO2+ (delta rxn Gzero' = 13 kcal/mol at pH 7) or (2) homolysis
Book ChapterDOI
Oxidative chemistry of peroxynitrite.
TL;DR: This chapter presents that essentially all of the nitric oxide produced by rat alveolar macrophages activated with phorbol ester is converted to peroxynitrite, a strong oxidant that can be stored for weeks in alkaline solution or even entrapped in solid forms.
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Evidence for nitric oxide-mediated oxidative damage in chronic inflammation : nitrotyrosine in serum and synovial fluid from rheumatoid patients
Harparkash Kaur,Barry Halliwell +1 more
TL;DR: Evidence that NO• plays a role in joint damage in rheumatoid arthritis is evidence that nitro‐aromatics may be ‘markers’ of NO•‐dependent oxidative damage.