Journal ArticleDOI
Effects of cocoa powder and dark chocolate on LDL oxidative susceptibility and prostaglandin concentrations in humans
Ying Wan,Joe A. Vinson,Terry D. Etherton,John Proch,Sheryl A. Lazarus,Penny M. Kris-Etherton +5 more
TLDR
Cocoa powder and dark chocolate may favorably affect cardiovascular disease risk status by modestly reducing LDL oxidation susceptibility, increasing serum total antioxidant capacity and HDL-cholesterol concentrations, and not adversely affecting prostaglandins.About:
This article is published in The American Journal of Clinical Nutrition.The article was published on 2001-11-01. It has received 342 citations till now. The article focuses on the topics: Dark chocolate & Oxygen radical absorbance capacity.read more
Citations
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Journal ArticleDOI
Bioactive compounds in foods: their role in the prevention of cardiovascular disease and cancer
Penny M. Kris-Etherton,Kari D Hecker,Andrea Bonanome,Stacie M. Coval,Amy E. Binkoski,Kirsten F Hilpert,Amy E. Griel,Terry D. Etherton +7 more
TL;DR: Many bioactive compounds are extranutritional constituents that typically occur in small quantities in foods and are grouped accordingly as phenolic compounds, including their subcategory, flavonoids as discussed by the authors.
Journal ArticleDOI
Bioavailability and bioefficacy of polyphenols in humans. II. Review of 93 intervention studies
Gary Williamson,Claudine Manach +1 more
TL;DR: It is time to rethink the design of in vitro and in vivo studies, so that these issues are carefully considered, and the length of human intervention studies should be increased, to more closely reflect the long-term dietary consumption of polyphenols.
Journal ArticleDOI
Consumption of flavonoid-rich foods and increased plasma antioxidant capacity in humans: cause, consequence, or epiphenomenon?
Silvina B. Lotito,Balz Frei +1 more
TL;DR: It is concluded that the large increase in plasma total antioxidant capacity observed after the consumption of flavonoid-rich foods is not caused by the flavonoids themselves, but is likely the consequence of increased uric acid levels.
Journal ArticleDOI
Health promotion by flavonoids, tocopherols, tocotrienols, and other phenols: direct or indirect effects? Antioxidant or not?
TL;DR: It is argued that tocopherols and tocotrienols may also exert direct beneficial effects in the gastrointestinal tract and that their return to theintestinal tract by the liver through the bile may be physiologically advantageous.
Journal ArticleDOI
Polyphenols and prevention of cardiovascular diseases.
TL;DR: Future intervention studies should include a detailed assessment of the bioavailability of polyphenols, and more studies with purepolyphenols will also be needed to establish their role in the prevention of cardiovascular diseases.
References
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Cryopreservation with sucrose maintains normal physical and biological properties of human plasma low density lipoproteins.
TL;DR: Cryopreservation of LDL in 10% sucrose (w/v) completely prevented the structural and functional changes incurred after short-term freezing, and LDL cryopreserved in sucrose for as long as 18 months displayed cell binding, uptake, and degradation very similar to that of freshly obtained LDL.
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Supplementation with wine phenolic compounds increases the antioxidant capacity of plasma and vitamin E of low-density lipoprotein without changing the lipoprotein Cu(2+)-oxidizability: possible explanation by phenolic location.
Marie-Annette Carbonneau,Claude L. Léger,Louis Monnier,C Bonnet,F. Michel,G. Fouret,F Dedieu,Bernard Descomps +7 more
TL;DR: In vitro studies showed that RWPC or sinapic, caffeic or ferulic acids incubated in the presence of LDL increased the protection of the lipoparticle against oxidation (caffeic>sinapic>ferulic) and was totally lost after extensive dialysis.
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Effect of temperature and phase transition on oxidation resistance of low density lipoprotein.
TL;DR: It is demonstrated that temperature exerts a clear effect in the Cu(2+)-mediated LDL oxidation, with a strong decrease in lag time and a notable increase in the rate of propagation, suggesting that the core melting point of the LDL has no or only a minor effect on these oxidation indices.
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The role of fatty acid saturation on plasma lipids, lipoproteins, and apolipoproteins: II. The plasma total and low-density lipoprotein cholesterol response of individual fatty acids
TL;DR: A predictive equation is developed to estimate changes in plasma TC and LDL cholesterol levels of young men in response to changes in dietary fatty acids and indicates that stearic acid has an independent cholesterol-lowering effect.