Journal ArticleDOI
Effects of cocoa powder and dark chocolate on LDL oxidative susceptibility and prostaglandin concentrations in humans
Ying Wan,Joe A. Vinson,Terry D. Etherton,John Proch,Sheryl A. Lazarus,Penny M. Kris-Etherton +5 more
TLDR
Cocoa powder and dark chocolate may favorably affect cardiovascular disease risk status by modestly reducing LDL oxidation susceptibility, increasing serum total antioxidant capacity and HDL-cholesterol concentrations, and not adversely affecting prostaglandins.About:
This article is published in The American Journal of Clinical Nutrition.The article was published on 2001-11-01. It has received 342 citations till now. The article focuses on the topics: Dark chocolate & Oxygen radical absorbance capacity.read more
Citations
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Bioactive compounds in foods: their role in the prevention of cardiovascular disease and cancer
Penny M. Kris-Etherton,Kari D Hecker,Andrea Bonanome,Stacie M. Coval,Amy E. Binkoski,Kirsten F Hilpert,Amy E. Griel,Terry D. Etherton +7 more
TL;DR: Many bioactive compounds are extranutritional constituents that typically occur in small quantities in foods and are grouped accordingly as phenolic compounds, including their subcategory, flavonoids as discussed by the authors.
Journal ArticleDOI
Bioavailability and bioefficacy of polyphenols in humans. II. Review of 93 intervention studies
Gary Williamson,Claudine Manach +1 more
TL;DR: It is time to rethink the design of in vitro and in vivo studies, so that these issues are carefully considered, and the length of human intervention studies should be increased, to more closely reflect the long-term dietary consumption of polyphenols.
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Consumption of flavonoid-rich foods and increased plasma antioxidant capacity in humans: cause, consequence, or epiphenomenon?
Silvina B. Lotito,Balz Frei +1 more
TL;DR: It is concluded that the large increase in plasma total antioxidant capacity observed after the consumption of flavonoid-rich foods is not caused by the flavonoids themselves, but is likely the consequence of increased uric acid levels.
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Health promotion by flavonoids, tocopherols, tocotrienols, and other phenols: direct or indirect effects? Antioxidant or not?
TL;DR: It is argued that tocopherols and tocotrienols may also exert direct beneficial effects in the gastrointestinal tract and that their return to theintestinal tract by the liver through the bile may be physiologically advantageous.
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Polyphenols and prevention of cardiovascular diseases.
TL;DR: Future intervention studies should include a detailed assessment of the bioavailability of polyphenols, and more studies with purepolyphenols will also be needed to establish their role in the prevention of cardiovascular diseases.
References
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Plasma kinetics in man of epicatechin from black chocolate
TL;DR: Epicatechin is absorbed from chocolate and is rapidly eliminated from plasma and the maximal concentration and area under the curve of plasma kinetics of both substrates correlated very well with the dose of chocolate.
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Antioxidants in chocolate
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Inhibition of LDL oxidation by cocoa
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Cocoa and Wine Polyphenols Modulate Platelet Activation and Function
Dietrich Rein,Teresa Paglieroni,Debra A. Pearson,Theodore Wun,Harold H. Schmitz,Robert C. Gosselin,Carl L. Keen +6 more
TL;DR: Select cocoa procyanidins and DRW added to whole blood in vitro increased expression of platelet activation markers in unstimulated platelets but suppressed the plateletactivation response to epinephrine, a suppressive effect observed on platelet reactivity.