Journal ArticleDOI
EG-VEGF and the concept of tissue-specific angiogenic growth factors.
TLDR
A novel angiogenic mitogen, endocrine-gland-derived vascular endothelial growth factor, EG-VEGF, with a selective activity and very distinct expression pattern is identified, which may represent the first of a novel class of tissue-specificAngiogenic factors that function to regulate and fine-tune endothelial cell growth, structural and functional properties.About:
This article is published in Seminars in Cell & Developmental Biology.The article was published on 2002-02-01. It has received 43 citations till now. The article focuses on the topics: Vascular endothelial growth factor B & Vascular endothelial growth factor A.read more
Citations
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Journal ArticleDOI
Vascular endothelial growth factor and kinase domain region receptor are involved in both seminiferous cord formation and vascular development during testis morphogenesis in the rat
TL;DR: It is concluded that VEGFA, secreted by the Sertoli cell, is involved in both neovascularization and cord formation and potentially acts through the PI3K pathway during testis morphogenesis to elicit its effects.
Journal ArticleDOI
Vascular cell biology in vivo: a new piscine paradigm?
TL;DR: Zebrafish have small, accessible, transparent embryos and larvae, facilitating high-resolution imaging in vivo, and genetic and experimental tools and methods available for functional manipulation of the entire organism, vascular tissues or even single vascular- or non-vascular cells make the fish amenable to 'in vivo vascular cell biology'.
Journal ArticleDOI
Retinopathy of prematurity: molecular pathology and therapeutic strategies.
Hadas Mechoulam,Eric A. Pierce +1 more
TL;DR: Potential medical therapies for ROP, including modulators of angiogenic factors, inhibitors of basement membrane changes, endogenous inhibitors such as pigment epithelium derived factor, and anti-inflammatory drugs, have shown efficacy against neovascularization in several animal models.
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Endocrine gland-derived vascular endothelial growth factor is expressed in human peri-implantation endometrium, but not in endometrial carcinoma.
TL;DR: Immunohistochemistry analysis showed that EG-VEGF is predominantly expressed in the glandular epithelial cells and its expression is dynamic during the menstrual cycle with a peak expression at the mid-luteal phase, which may imply that EG -VEGF may only play a role in vascular function of peri-implantation endometrium, but is unlikely to be associated with the etiology of endometrial cancer development.
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The multiple roles of EG-VEGF/PROK1 in normal and pathological placental angiogenesis.
Nadia Alfaidy,Pascale Hoffmann,Houssine Boufettal,Naïma Samouh,Touria Aboussaouira,Mohamed Benharouga,Jean-Jacques Feige,Jean-Jacques Feige,Jean-Jacques Feige,Sophie Brouillet +9 more
TL;DR: This paper argues for EG-VEGF clinical relevance as a potential biomarker of the onset of pregnancy pathologies and discusses its potential usefulness for future therapeutic directions.
References
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Angiogenesis in cancer, vascular, rheumatoid and other disease
TL;DR: Think of the switch to the angiogenic phenotype as a net balance of positive and negative regulators of blood vessel growth, which may dictate whether a primary tumour grows rapidly or slowly and whether metastases grow at all.
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Mechanisms of angiogenesis
TL;DR: Understanding of the molecular basis underlying angiogenesis, particularly from the study of mice lacking some of the signalling systems involved, has greatly improved, and may suggest new approaches for treating conditions such as cancer that depend onAngiogenesis.
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New perspectives in cell adhesion : RGD and integrins
TL;DR: Together, the adhesion proteins and their receptors constitute a versatile recognition system providing cells with anchorage, traction for migration, and signals for polarity, position, differentiation, and possibly growth.
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Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis.
TL;DR: It is shown that vascular endothelial growth factor (VEGF) probably functions as a hypoxia-inducible angiogenic factor and is specifically induced in a subset of glioblastoma cells distinguished by their immediate proximity to necrotic foci and the clustering of capillaries alongside VEGF-producing cells.
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Integrins: a family of cell surface receptors.
TL;DR: This brief review of sequence data from embryogenesis, thrombosis, and lymphocyte help and killing is summarized and attempts to clarify the relationships among the members of this family of cell surface receptors.