Journal ArticleDOI
Empirical fitness landscapes and the predictability of evolution
TLDR
This work reviews recent empirical and theoretical developments of the genotype–fitness map, identifies methodological issues and organizing principles, and discusses possibilities to develop more realistic fitness landscape models.Abstract:
A central topic in biology concerns how genotypes determine phenotypes and functions of organisms that affect their evolutionary fitness. This Review discusses recent advances in the development of empirical fitness landscapes and their contribution to theoretical analyses of the predictability of evolution. The genotype–fitness map (that is, the fitness landscape) is a key determinant of evolution, yet it has mostly been used as a superficial metaphor because we know little about its structure. This is now changing, as real fitness landscapes are being analysed by constructing genotypes with all possible combinations of small sets of mutations observed in phylogenies or in evolution experiments. In turn, these first glimpses of empirical fitness landscapes inspire theoretical analyses of the predictability of evolution. Here, we review these recent empirical and theoretical developments, identify methodological issues and organizing principles, and discuss possibilities to develop more realistic fitness landscape models.read more
Citations
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Journal ArticleDOI
Mutual influence of secondary and key drug-resistance mutations on catalytic properties and thermal stability of TEM-type β-lactamases.
Vitaly G. Grigorenko,I. V. Uporov,Maya Yu. Rubtsova,I. P. Andreeva,Dmitrii S. Shcherbinin,Alexander V. Veselovsky,Oksana Serova,M. M. Ulyashova,Igor Ishtubaev,Alexey M. Egorov +9 more
TL;DR: Replacement of Q39 by lysine in combination with the key drug resistance mutations may be responsible for loss of protein thermal stability and elevated mobility of its secondary structure elements.
Posted ContentDOI
Mutation bias interacts with composition bias to influence adaptive evolution
A. V. Cano,Joshua L. Payne +1 more
TL;DR: The results reveal the way in which composition bias interacts with biases in the mutation process under different population genetic conditions, and how such interaction impacts fundamental properties of adaptive evolution, such as its predictability, as well as the evolution of genetic diversity and mutational robustness.
Journal ArticleDOI
Evolutionary transitions in controls reconcile adaptation with continuity of evolution.
TL;DR: It is shown that accumulating redundancy in one type of network controls inevitably leads to the emergence of another type of controls, forming evolutionary cycles of network controllability that reconcile local adaptation with continuity of evolution.
Posted ContentDOI
Collateral sensitivity is contingent on the repeatability of evolution
Daniel Nichol,Joseph D Rutter,Christopher Bryant,Peter Jeavons,Alexander R. A. Anderson,Robert A. Bonomo,Jacob G. Scott +6 more
TL;DR: In this paper, the authors demonstrate that sequential multi-drug therapies derived from in vitro evolution experiments can have overstated therapeutic benefit - potentially suggesting a collaterally sensitive response where cross resistance ultimately occurs.
Journal ArticleDOI
Mutagenesis Scanning Uncovers Evolutionary Constraints on Tobacco Etch Potyvirus Membrane-Associated 6K2 Protein.
TL;DR: A mutant library of the 6K2 gene of tobacco etch potyvirus that contains every possible single-nucleotide substitution suggests that in nature selection upon 6K1 may result from a tradeoff between within-host accumulation and severity of symptoms.
References
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Journal ArticleDOI
Evolution in Mendelian Populations.
TL;DR: Page 108, last line of text, for "P/P″" read "P′/ P″."
Journal ArticleDOI
Evolution in Mendelian populations
TL;DR: The frequency of a given gene in a population may be modified by a number of conditions including recurrent mutation to and from it, migration, selection of various sorts and, far from least in importance, were chance variation.
Book
Wonderful Life: The Burgess Shale and the Nature of History
TL;DR: In this article, the authors explore what the Burgess Shale tells us about evolution and the nature of history and find that it holds the remains of an ancient sea where dozens of strange creatures lived.
Journal ArticleDOI
Epistasis--the essential role of gene interactions in the structure and evolution of genetic systems.
TL;DR: There is a renewed appreciation both for the importance of studying gene interactions and for addressing these questions in a unified, quantitative manner with the advent of high-throughput functional genomics.