Journal ArticleDOI
Engineering stilbene metabolic pathways in microbial cells.
Philippe Jeandet,Eduardo Sobarzo-Sánchez,Christophe Clément,Seyed Fazel Nabavi,Solomon Habtemariam,Seyed Mohammad Nabavi,Sylvain Cordelier +6 more
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TLDR
This review presents the combined efforts made during the past 15 years to engineer stilbene metabolic pathways in microbial cells, mainly the Saccharomyces cerevisiae baker yeast, the Escherichia coli and the Corynebacterium glutamicum bacteria.About:
This article is published in Biotechnology Advances.The article was published on 2018-12-01. It has received 42 citations till now. The article focuses on the topics: Metabolic engineering.read more
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The Therapeutic Potential of Naringenin: A Review of Clinical Trials.
Bahare Salehi,Patrick Valere Tsouh Fokou,Mehdi Sharifi-Rad,Paolo Zucca,Raffaele Pezzani,Natália Martins,Javad Sharifi-Rad,Javad Sharifi-Rad +7 more
TL;DR: The currently available data are very promising, but further research on pharmacokinetic and pharmacodynamic aspects is encouraged to improve both available production and delivery methods and to achieve feasible naringenin-based clinical formulations.
Journal ArticleDOI
Influence of Resveratrol on the Immune Response
TL;DR: A systematic understanding of how resveratrol targets multiple inflammatory components and exerts immune-regulatory effects on immune cells is offered.
Journal ArticleDOI
New insights into the degradation of synthetic pollutants in contaminated environments.
Pankaj Bhatt,Saurabh Gangola,Geeta Bhandari,Wenping Zhang,Damini Maithani,Sandhya Mishra,Shaohua Chen +6 more
TL;DR: This review provides an in-depth discussion of microbial engineering techniques that are used to enhance the removal of both organic and inorganic pollutants from different contaminated environments and under different conditions.
Journal ArticleDOI
Resveratrol Inhibits the Migration and Metastasis of MDA-MB-231 Human Breast Cancer by Reversing TGF-β1-Induced Epithelial-Mesenchymal Transition.
TL;DR: Results indicate that resveratrol inhibits the migration of MDA231 cells by reversing TGF-β1-induced EMT and inhibits the lung metastasis of Mda231 human breast cancer in a xenograft-bearing mouse model.
Journal ArticleDOI
Neuroprotective role of polyphenols against oxidative stress-mediated neurodegeneration.
Md. Sahab Uddin,Abdullah Al Mamun,Md. Tanvir Kabir,Jamil Ahmad,Philippe Jeandet,Md. Shahid Sarwar,Ghulam Md Ashraf,Lotfi Aleya +7 more
TL;DR: The potential efficacy ofpolyphenols such as epigallocatechin-3-gallate, curcumin, resveratrol, quercetin and methylated polyphenols berberine against the most common neurodegenerative disorders is focused on.
References
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Cancer Chemopreventive Activity of Resveratrol, a Natural Product Derived from Grapes
Mei-Shiang Jang,Lining Cai,George Udeani,Karla Slowing,Cathy F. Thomas,Chris Beecher,Harry H. S. Fong,Norman R. Farnsworth,A. Douglas Kinghorn,Rajendra G. Mehta,Richard C. Moon,John M. Pezzuto +11 more
TL;DR: It is suggested that resveratrol, a common constituent of the human diet, merits investigation as a potential cancer chemopreventive agent in humans.
Journal ArticleDOI
Therapeutic potential of resveratrol: the in vivo evidence.
Joseph A. Baur,David A. Sinclair +1 more
TL;DR: A comprehensive and critical review of the in vivo data on resveratrol is provided, and its potential as a therapeutic for humans is considered.
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Wine, alcohol, platelets, and the French paradox for coronary heart disease
Serge Renaud,M de Lorgeril +1 more
TL;DR: Data from Caerphilly, Wales, show that platelet aggregation, which is related to CHD, is inhibited significantly by alcohol at levels of intake associated with reduced risk of CHD.
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Production of the antimalarial drug precursor artemisinic acid in engineered yeast
Dae-Kyun Ro,Eric M. Paradise,Mario Ouellet,Karl Fisher,Karyn L. Newman,John M. Ndungu,Ho Kimberly,Eachus Rachel,Timothy S. Ham,James Kirby,Michelle C. Y. Chang,Sydnor T. Withers,Yoichiro Shiba,Richmond Sarpong,Jay D. Keasling +14 more
TL;DR: The engineering of Saccharomyces cerevisiae to produce high titres (up to 100 mg l-1) of artemisinic acid using an engineered mevalonate pathway, amorphadiene synthase, and a novel cytochrome P450 monooxygenase from A. annua that performs a three-step oxidation of amorpha-4,11-diene to art Artemisinic acid.
Journal ArticleDOI
High absorption but very low bioavailability of oral resveratrol in humans
TL;DR: The dietary polyphenol resveratrol has been shown to have chemopreventive activity against cardiovascular disease and a variety of cancers in model systems, but it is not clear whether the drug reaches the proposed sites of action in vivo after oral ingestion, especially in humans.