Epigenetics of host-pathogen interactions: the road ahead and the road behind.
TLDR
The evidence available for the role epigenetics on host- Pathogen interactions, and the utility and versatility of the epigenetic technologies available that can be cross-applied to host-pathogen studies are reviewed are reviewed.Abstract:
A growing body of evidence points towards epigenetic mechanisms being responsible for a wide range of biological phenomena, from the plasticity of plant growth and development to the nutritional control of caste determination in honeybees and the etiology of human disease (e.g., cancer). With the (partial) elucidation of the molecular basis of epigenetic variation and the heritability of certain of these changes, the field of evolutionary epigenetics is flourishing. Despite this, the role of epigenetics in shaping host–pathogen interactions has received comparatively little attention. Yet there is plenty of evidence supporting the implication of epigenetic mechanisms in the modulation of the biological interaction between hosts and pathogens. The phenotypic plasticity of many key parasite life-history traits appears to be under epigenetic control. Moreover, pathogen-induced effects in host phenotype may have transgenerational consequences, and the bases of these changes and their heritability probably have an epigenetic component. The significance of epigenetic modifications may, however, go beyond providing a mechanistic basis for host and pathogen plasticity. Epigenetic epidemiology has recently emerged as a promising area for future research on infectious diseases. In addition, the incorporation of epigenetic inheritance and epigenetic plasticity mechanisms to evolutionary models and empirical studies of host–pathogen interactions will provide new insights into the evolution and coevolution of these associations. Here, we review the evidence available for the role epigenetics on host–pathogen interactions, and the utility and versatility of the epigenetic technologies available that can be cross-applied to host–pathogen studies. We conclude with recommendations and directions for future research on the burgeoning field of epigenetics as applied to host–pathogen interactions.read more
Citations
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Microbial genes, brain & behaviour - epigenetic regulation of the gut-brain axis.
TL;DR: It is suggested that gut‐microbial products can affect chromatin plasticity within their host's brain that in turn leads to changes in neuronal transcription and eventually alters host behaviour, and that the microbiota itself may be viewed as an epigenetic entity.
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Tick-Pathogen Interactions and Vector Competence: Identification of Molecular Drivers for Tick-Borne Diseases
José de la Fuente,José de la Fuente,Sandra Antunes,Sarah Bonnet,Alejandro Cabezas-Cruz,Alejandro Cabezas-Cruz,Alejandro Cabezas-Cruz,Ana Domingos,Agustín Estrada-Peña,Nicholas Johnson,Nicholas Johnson,Katherine M. Kocan,Karen L. Mansfield,Karen L. Mansfield,Ard M. Nijhof,Anna Papa,Nataliia Rudenko,Margarita Villar,Pilar Alberdi,Alessandra Torina,Nieves Ayllón,Marie Vancová,Maryna Golovchenko,Libor Grubhoffer,Libor Grubhoffer,Santo Caracappa,Anthony R. Fooks,Anthony R. Fooks,Christian Gortázar,Ryan O. M. Rego,Ryan O. M. Rego +30 more
TL;DR: This review provides a comprehensive overview of tick-pathogen molecular interactions for bacteria, viruses, and protozoa affecting human and animal health and suggests some of the similar mechanisms used by the pathogens for infection and transmission by ticks may assist in development of preventative strategies against multiple tick-borne diseases.
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Insect Pathogenic Fungi: Genomics, Molecular Interactions, and Genetic Improvements.
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Pathogenic Influenza Viruses and Coronaviruses Utilize Similar and Contrasting Approaches To Control Interferon-Stimulated Gene Responses
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