Journal ArticleDOI
Estimation of dehydroascorbic acid in blood of diabetic patients
I. B. Chatterjee,A. Banerjee +1 more
Reads0
Chats0
TLDR
The DHA from diabetic blood has been isolated as the 2,4-dinitrophenylhydrazone derivative and identified by thin-layer chromatography and spectrophotometry.About:
This article is published in Analytical Biochemistry.The article was published on 1979-10-01. It has received 77 citations till now. The article focuses on the topics: Dehydroascorbic acid & Ascorbic acid.read more
Citations
More filters
Journal ArticleDOI
Mechanism of formation of the Maillard protein cross-link pentosidine. Glucose, fructose, and ascorbate as pentosidine precursors.
TL;DR: The discovery that pentosidine can form not only from pentoses but also from hexoses and ascorbate raises major new questions concerning biochemical pathways of the Maillard reaction in vivo.
Journal ArticleDOI
Glucose Transporter Isoforms GLUT1 and GLUT3 Transport Dehydroascorbic Acid
Steven C. Rumsey,Oran Kwon,Guo Wei Xu,Charles F. Burant,Ian A. Simpson,Mark Levine,Mark Levine +6 more
TL;DR: GLUT1 and GLUT3 isoforms are the specific glucose transporter isoforms which mediate DHA transport and subsequent accumulation of AA according to Xenopus laevis oocyte expression system studies.
Journal ArticleDOI
Dietary Antioxidant Intake and Risk of Type 2 Diabetes
TL;DR: In this paper, the intake of antioxidants was studied for its ability to predict type 2 diabetes in a cohort of 2,285 men and 2,019 women 40-69 years of age and free of diabetes at baseline (1967-1972).
Journal ArticleDOI
Maillard reaction-mediated molecular damage to extracellular matrix and other tissue proteins in diabetes, aging, and uremia.
Vincent M. Monnier,David R. Sell,Ramanakoppa H. Nagaraj,Satoshi Miyata,Sunitha K. Grandhee,Patrizio Odetti,Said A Ibrahim +6 more
TL;DR: Immunohistochemical localization studies revealed that pyrraline is found predominantly in the sclerosed extracellular matrix of glomerular and arteriolar renal tissues from both diabetic and aged nondiabetic individuals, suggesting that molecular damage by advanced Maillard reaction products may be a common mechanism in their development.
Journal ArticleDOI
Pentosidine Formation in Skin Correlates With Severity of Complications in Individuals With Long-Standing IDDM
TL;DR: A high correlation betweenpentosidine levels and long-wave collagen-linked fluorescence also was observed, suggesting that pentosidine is a generalized marker of accelerated tissue modification by the advanced glycosylation/Maillard reaction, which is enhanced in IDDM patients with severe complications.
References
More filters
Journal ArticleDOI
The quantitative determination of ascorbic acid in small amounts of white blood cells and platelets.
Journal ArticleDOI
The diabetogenic effect of dehydroascorbic and dehydroisoascorbic acids.
TL;DR: The chemical properties of these two substances are strikingly similar and it would appear logical to expect that there might be a relationship between alloxan and dehydroascorbic acid with regard to the production of diabetes.
Journal ArticleDOI
Appraisal of methods for the determination of L-ascorbic acid.
TL;DR: Photometric methods have the following advantages in comparison with visual titration procedures: the inaccuracy due to difficulty in judging a rapidly disappearing end point is eliminated, and the effect of turbidity or pigmentation in the unknown mixture can be overcome to a considerable extent by adjustment of the colorimeter.
Journal ArticleDOI
Effect of cyanide on the biosynthesis of ascorbic acid by an enzyme preparation from goat-liver tissue.
TL;DR: The present paper deals with detailed studies of this enzyme preparation of ascorbic acid in plant and animal systems respectively and found that Liver tissues of all the mammals investigated could bring about this cyanide-stimulated synthesis, but homogenates of the brain (rat), kidney (rat and goat) or adrenal gland (cow) were ineffective in this respect.