Evaluation, Treatment, and Prevention of Vitamin D Deficiency: an Endocrine Society Clinical Practice Guideline
Michael F. Holick,Neil Binkley,Heike A. Bischoff-Ferrari,Catherine M. Gordon,David A. Hanley,Robert P. Heaney,M. Hassan Murad,Connie M. Weaver +7 more
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TLDR
Considering that vitamin D deficiency is very common in all age groups and that few foods contain vitamin D, the Task Force recommended supplementation at suggested daily intake and tolerable upper limit levels, depending on age and clinical circumstances.Abstract:
Objective: The objective was to provide guidelines to clinicians for the evaluation, treatment, and prevention of vitamin D deficiency with an emphasis on the care of patients who are at risk for deficiency. Participants: The Task Force was composed of a Chair, six additional experts, and a methodologist. The Task Force received no corporate funding or remuneration. Consensus Process: Consensus was guided by systematic reviews of evidence and discussions during several conference calls and e-mail communications. The draft prepared by the Task Force was reviewed successively by The Endocrine Society's Clinical Guidelines Subcommittee, Clinical Affairs Core Committee, and cosponsoring associations, and it was posted on The Endocrine Society web site for member review. At each stage of review, the Task Force received written comments and incorporated needed changes. Conclusions: Considering that vitamin D deficiency is very common in all age groups and that few foods contain vitamin D, the Task Force recomme...read more
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Vitamin D Signaling through Induction of Paneth Cell Defensins Maintains Gut Microbiota and Improves Metabolic Disorders and Hepatic Steatosis in Animal Models
Danmei Su,Yuanyang Nie,Airu Zhu,Zishuo Chen,Pengfei Wu,Li Zhang,Mei Luo,Qun Sun,Linbi Cai,Yuchen Lai,Zhixiong Xiao,Zhongping Duan,Sujun Zheng,Guihui Wu,Richard Hu,Hidekazu Tsukamoto,Aurelia Lugea,Zhenqui Liu,Stephen J. Pandol,Yuan-Ping Han +19 more
TL;DR: Critical roles of a vitamin D/VDR axis in optimal expression of defensins and tight junction genes in support of intestinal integrity and eubiosis to suppress NAFLD and metabolic disorders are revealed.
Journal ArticleDOI
The epidemiology and management of postmenopausal osteoporosis: a viewpoint from Brazil
TL;DR: The Brazilian government provides medication for osteoporosis through the public health system free of charge, but without proper epidemiological knowledge, the implementation of public health programs is impaired.
Journal ArticleDOI
Vitamin D and Neurological Diseases: An Endocrine View.
Carolina Di Somma,Elisabetta Scarano,Luigi Barrea,Volha V. Zhukouskaya,Silvia Savastano,Chiara Mele,Massimo Scacchi,Gianluca Aimaretti,Annamaria Colao,Paolo Marzullo +9 more
TL;DR: The aim of this review is to highlight the relationship between vitamin D and neurological diseases and suggest optimal levels of vitamin D in the bloodstream are also necessary to preserve the neurological development and protect the adult brain.
Journal ArticleDOI
Vitamin D Deficiency: Defining, Prevalence, Causes, and Strategies of Addressing
TL;DR: A number of strategies that can be considered for the control of micronutrient malnutrition, these include (i) increasing the diversity of foods consumed, (ii) food fortification, and (iii) supplementation are considered.
Journal ArticleDOI
Seasonal variations in serum 25-hydroxy vitamin D levels in a Swedish cohort
TL;DR: Serum 25(OH)D was strongly associated with parameters related to sun exposure, but only weakly with intake of vitamin D supplements, and was significantly higher in holiday makers in sunny destinations, sunbed users, non-smokers, and in the physically active.
References
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Journal ArticleDOI
Vitamin D Deficiency
TL;DR: The role of vitamin D in skeletal and nonskeletal health is considered and strategies for the prevention and treatment ofitamin D deficiency are suggested.
Journal ArticleDOI
Grading quality of evidence and strength of recommendations.
David C. Atkins,Dana Best,Peter A. Briss,Martin P Eccles,Yngve Falck-Ytter,Signe Flottorp,Gordon H. Guyatt,Robin Harbour,Margaret C Haugh,David Henry,Suzanne Hill,Roman Jaeschke,Gillian Leng,Alessandro Liberati,Nicola Magrini,James Mason,Philippa Middleton,Jacek Mrukowicz,Dianne L. O'Connell,Andrew D Oxman,Bob Phillips,Holger J. Schünemann,Tessa Tan-Torres Edejer,H. Varonen,Gunn Elisabeth Vist,John W Williams,Stephanie Zaza +26 more
TL;DR: A system for grading the quality of evidence and the strength of recommendations that can be applied across a wide range of interventions and contexts is developed, and a summary of the approach from the perspective of a guideline user is presented.
Book
Vitamin D
TL;DR: In what case do you like reading so much? What about the type of the vitamin d the calcium homeostatic steroid hormone book? The needs to read? Well, everybody has their own reason why should read some books as discussed by the authors.
Journal ArticleDOI
Toll-Like Receptor Triggering of a Vitamin D-Mediated Human Antimicrobial Response
Philip T. Liu,Steffen Stenger,Huiying Li,Linda Wenzel,Belinda H. Tan,Stephan R. Krutzik,Maria Teresa Ochoa,Jürgen Schauber,Kent Wu,Christoph Meinken,Diane L. Kamen,Manfred Wagner,Robert Bals,Andreas Steinmeyer,Ulrich Zügel,Richard L. Gallo,David Eisenberg,Martin Hewison,Bruce W. Hollis,John S. Adams,Barry R. Bloom,Robert L. Modlin +21 more
TL;DR: The data support a link between TLRs and vitamin D–mediated innate immunity and suggest that differences in ability of human populations to produce vitamin D may contribute to susceptibility to microbial infection.
Book
Dietary Reference Intakes for Calcium and Vitamin D
TL;DR: The evidence supported a role for these nutrients in bone health but not in other health conditions, and there is emerging evidence that too much of these nutrients may be harmful.