Evaluation, Treatment, and Prevention of Vitamin D Deficiency: an Endocrine Society Clinical Practice Guideline
Michael F. Holick,Neil Binkley,Heike A. Bischoff-Ferrari,Catherine M. Gordon,David A. Hanley,Robert P. Heaney,M. Hassan Murad,Connie M. Weaver +7 more
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TLDR
Considering that vitamin D deficiency is very common in all age groups and that few foods contain vitamin D, the Task Force recommended supplementation at suggested daily intake and tolerable upper limit levels, depending on age and clinical circumstances.Abstract:
Objective: The objective was to provide guidelines to clinicians for the evaluation, treatment, and prevention of vitamin D deficiency with an emphasis on the care of patients who are at risk for deficiency. Participants: The Task Force was composed of a Chair, six additional experts, and a methodologist. The Task Force received no corporate funding or remuneration. Consensus Process: Consensus was guided by systematic reviews of evidence and discussions during several conference calls and e-mail communications. The draft prepared by the Task Force was reviewed successively by The Endocrine Society's Clinical Guidelines Subcommittee, Clinical Affairs Core Committee, and cosponsoring associations, and it was posted on The Endocrine Society web site for member review. At each stage of review, the Task Force received written comments and incorporated needed changes. Conclusions: Considering that vitamin D deficiency is very common in all age groups and that few foods contain vitamin D, the Task Force recomme...read more
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Vitamin D and cardiovascular disease: is the evidence solid?
TL;DR: Randomized trials of vitamin D replacement employing cardiovascular endpoints will provide much needed evidence for determining its role in cardiovascular protection, and questions of an epiphenomenon where vitamin D status merely reflects a classic risk burden have been raised.
Journal ArticleDOI
Gestational Vitamin D deficiency and autism-related traits: The Generation R Study
Anna A. E. Vinkhuyzen,Darryl W. Eyles,Darryl W. Eyles,Thomas H. J. Burne,Thomas H. J. Burne,Laura M. E. Blanken,Claudia J. Kruithof,Frank C. Verhulst,Vincent W. V. Jaddoe,Henning Tiemeier,John J. McGrath,John J. McGrath,John J. McGrath +12 more
TL;DR: In this article, the association between gestational vitamin D deficiency and a continuous measure of autism-related traits at ~6 years was determined in a large population-based cohort of mothers and their children (n=4229).
Journal ArticleDOI
The concept of the personal vitamin D response index.
Carsten Carlberg,Afrozul Haq +1 more
TL;DR: The need for vitamin D supplementation depends on theitamin D status in relation to the personal vitamin D response index of an individual rather than on the vitamin D status alone.
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Vitamin D status of Irish adults: findings from the National Adult Nutrition Survey
Kevin D. Cashman,S Muldowney,Breige A. McNulty,Anne P. Nugent,Anthony P. Fitzgerald,Mairead Kiely,Janette Walton,Michael J. Gibney,Albert Flynn +8 more
TL;DR: These first nationally representative serum 25(OH)D data for Irish adults show that while only 6·7 % had serum 25-hydroxyvitamin D deficiency throughout the year, 40·1 % had levels considered by the Institute of Medicine as being inadequate for bone health during winter time.
Journal ArticleDOI
Influence of Vitamin D on Islet Autoimmunity and Beta-Cell Function in Type 1 Diabetes
Marco Infante,Marco Infante,Camillo Ricordi,Janine Sanchez,Michael J. Clare-Salzler,Nathalia Padilla,Virginia Fuenmayor,Carmen Chavez,Ana Alvarez,David A. Baidal,Rodolfo Alejandro,Massimiliano Caprio,Andrea Fabbri +12 more
TL;DR: The current knowledge on the immunomodulatory effects of vitamin D is presented and the clinical interventional studies investigating its use for prevention or treatment of T1D are summarized.
References
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Vitamin D Deficiency
TL;DR: The role of vitamin D in skeletal and nonskeletal health is considered and strategies for the prevention and treatment ofitamin D deficiency are suggested.
Journal ArticleDOI
Grading quality of evidence and strength of recommendations.
David C. Atkins,Dana Best,Peter A. Briss,Martin P Eccles,Yngve Falck-Ytter,Signe Flottorp,Gordon H. Guyatt,Robin Harbour,Margaret C Haugh,David Henry,Suzanne Hill,Roman Jaeschke,Gillian Leng,Alessandro Liberati,Nicola Magrini,James Mason,Philippa Middleton,Jacek Mrukowicz,Dianne L. O'Connell,Andrew D Oxman,Bob Phillips,Holger J. Schünemann,Tessa Tan-Torres Edejer,H. Varonen,Gunn Elisabeth Vist,John W Williams,Stephanie Zaza +26 more
TL;DR: A system for grading the quality of evidence and the strength of recommendations that can be applied across a wide range of interventions and contexts is developed, and a summary of the approach from the perspective of a guideline user is presented.
Book
Vitamin D
TL;DR: In what case do you like reading so much? What about the type of the vitamin d the calcium homeostatic steroid hormone book? The needs to read? Well, everybody has their own reason why should read some books as discussed by the authors.
Journal ArticleDOI
Toll-Like Receptor Triggering of a Vitamin D-Mediated Human Antimicrobial Response
Philip T. Liu,Steffen Stenger,Huiying Li,Linda Wenzel,Belinda H. Tan,Stephan R. Krutzik,Maria Teresa Ochoa,Jürgen Schauber,Kent Wu,Christoph Meinken,Diane L. Kamen,Manfred Wagner,Robert Bals,Andreas Steinmeyer,Ulrich Zügel,Richard L. Gallo,David Eisenberg,Martin Hewison,Bruce W. Hollis,John S. Adams,Barry R. Bloom,Robert L. Modlin +21 more
TL;DR: The data support a link between TLRs and vitamin D–mediated innate immunity and suggest that differences in ability of human populations to produce vitamin D may contribute to susceptibility to microbial infection.
Book
Dietary Reference Intakes for Calcium and Vitamin D
TL;DR: The evidence supported a role for these nutrients in bone health but not in other health conditions, and there is emerging evidence that too much of these nutrients may be harmful.