Expression levels of seven candidate genes in human peripheral blood mononuclear cells and their association with preeclampsia.
Margarita L Martinez-Fierro,Idalia Garza-Veloz,K. Carrillo-Sanchez,Victoria Martinez-Gaytan,Raúl Cortés-Flores,M. A. Ochoa-Torres,G. G. Guerrero,Iram P. Rodriguez-Sanchez,C. O. Cancela-Murrieta,Michelle de Jesús Zamudio-Osuna,Jose I. Badillo-Almaraz,C. Castruita-de la Rosa +11 more
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TLDR
PBMC underexpression of VEGF-A and TGF-β1 is a hallmark of PE in the study population.Abstract:
Objective: To evaluate the peripheral blood mononuclear cell (PBMC) expression levels of hemeoxygenase 1 (HMOX-1), superoxide dismutase 1 (SOD-1), vascular endothelial growth factor A (VEGF-A), transforming growth factor beta 1 (TGF-β1), interleukin (IL)-6, IL-15 and AdipoQ genes to study their association with preeclampsia (PE). Methods: A total of 177 pregnant women were recruited: 108 cases and 69 controls. Quantification of gene expression was measured by quantitative real-time polymerase chain reaction (PCR) using TaqMan probes. Results: Underexpression of VEGF-A and TGF-β1 was a constant in most of the cases (80.91% and 76.36%, respectively) and their expression was associated with onset and/or severity of disease (p values < 0.05). IL-6, IL-15 and AdipoQ, showed low or no expression in PBMC samples evaluated. Conclusion: PBMC underexpression of VEGF-A and TGF-β1 is a hallmark of PE in the study population.read more
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A possible protective role of Nrf2 in preeclampsia
TL;DR: Recent theories about how Nrf2 is involved in the pathogenesis of preeclampsia are summarized and the reasons for considering NRF2 as a therapeutic target for the treatment of preeClampsiaare presented.
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The role of interleukins in preeclampsia: A comprehensive review.
Ioannis Bellos,Vasilios Karageorgiou,Dimitrios Kapnias,Konstantina-Eleni Karamanli,Charalampos Siristatidis +4 more
TL;DR: The present review accumulates current knowledge about the contribution of interleukins in preeclampsia, summarizing the pathways through which eachinterleukin exerts its function in the disease.
Journal ArticleDOI
Circulating levels of specific members of chromosome 19 microRNA cluster are associated with preeclampsia development
Margarita L Martinez-Fierro,Idalia Garza-Veloz,Cristina Gutierrez-Arteaga,Ivan Delgado-Enciso,O. Barbosa-Cisneros,Virginia Flores-Morales,Gloria P. Hernandez-Delgadillo,María del Refugio Rocha-Pizaña,Iram P. Rodriguez-Sanchez,Jose I. Badillo-Almaraz,J. M. Ortiz-Rodriguez,Rodrigo Castañeda-Miranda,Luis Octavio Solís-Sánchez,Yolanda Ortiz-Castro +13 more
TL;DR: Serum levels of hsa-miR-518f-3p at 20 GW were useful for identifying WWD-Mild-PE andWWD-Severe-PE, and their role in the development of preeclampsia should be investigated further.
Journal ArticleDOI
An exploratory study into the role of miR-204-5p in pregnancy-induced hypertension
TL;DR: Low levels of miR-204-5p may increase cell proliferation and reduce cell apoptosis with cell cycle changes in vitro, and may be used as a notable biomarker for the diagnosis, prevention and treatment of PIH.
Journal ArticleDOI
Early pregnancy protein multiplex screening reflects circulating and urinary divergences associated with the development of preeclampsia.
Margarita L Martinez-Fierro,Claudia Castruita-De la Rosa,Idalia Garza-Veloz,Rosa M Cardiel-Hernandez,Marcela A. Espinoza-Juarez,Ivan Delgado-Enciso,Maria E Castañeda-Lopez,Edith Cardenas-Vargas,Fabiola Trejo-Vazquez,Elma I Sotelo-Ham,Rodrigo Castañeda-Miranda,Miguel A Cid-Baez,J. M. Ortiz-Rodriguez,Luis Octavio Solís-Sánchez,Angelica Garcia Aviles,Yolanda Ortiz-Castro +15 more
TL;DR: The proteins sEGFR, HGF, ANG-2, sFASL, IL-6, PLGF, VEGF-A, PRL, TGF-α FGF-b, sHER2/Neu sIL-6Rα, ENG, uPA, and insulin-like growth factor binding protein 1 (IGFBP-1), were predictive of the development of preeclampsia and their use as markers for this disease should be considered.
References
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HMEC-1: Establishment of an immortalized human microvascular endothelial cell line
Edwin W. Ades,Francisco J. Candal,Robert A. Swerlick,Velma G. George,Susan Summers,Diane Bosse,Thomas J. Lawley +6 more
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