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From 2000 to mid-2010: a fruitful decade for the synthesis of pyrazoles.
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This article is published in Chemical Reviews.The article was published on 2011-08-01. It has received 839 citations till now.read more
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Synthesis and Pharmacological Activities of Pyrazole Derivatives: A Review
Khalid Karrouchi,Smaail Radi,Youssef Ramli,Jamal Taoufik,Yahia N. Mabkhot,Faiz A. Al-aizari,M'hammed Ansar +6 more
TL;DR: The different synthesis methods and the pharmacological properties of pyrazole derivatives developed by many scientists around the globe are highlighted.
Journal ArticleDOI
1,3,4-Thiadiazole: Synthesis, Reactions, and Applications in Medicinal, Agricultural, and Materials Chemistry
Journal ArticleDOI
Arylglyoxals in synthesis of heterocyclic compounds.
Journal ArticleDOI
Asymmetric synthesis of pyrazoles and pyrazolones employing the reactivity of pyrazolin-5-one derivatives
TL;DR: Progress is made in the catalytic asymmetric synthesis of pyrazoles and pyrazolones using pyrazolin-5-one derivatives using organo- and metal-catalysts.
Journal ArticleDOI
Coordination polymers and metal–organic frameworks based on poly(pyrazole)-containing ligands
TL;DR: In this article, a survey on transition metal containing coordination polymers and metal-organic frameworks (MOFs) with poly(pyrazole)-and poly (pyrazolate)-based ligands is presented, where up to three N-donor heterocyclic rings are organized on rigid or flexible cores.
References
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Journal ArticleDOI
Trifluoromethyl-substituted pyridyl- and pyrazolylboronic acids and esters: synthesis and Suzuki-Miyaura cross-coupling reactions.
TL;DR: X-Ray crystal structures are reported for selected pyridylboronic acids, pyrazolylboronic esters and derived trifluoromethyl-substituted heterobiaryl systems, which are of interest as building blocks for drug discovery and materials chemistry.
Journal ArticleDOI
1,3-Dipolar cycloaddition reactions of vinylidenecyclopropane-diesters with aromatic diazomethanes generated in situ.
TL;DR: 1,3-Dipolar cycloaddition reactions of VDCP-diesters with aromatic diazomethanes generated in situ from the corresponding aromatic aldehydes and tosylhydrazine mediated by base produce pyrazole derivatives in good yields under mild conditions.
Journal ArticleDOI
Efficient Cross-Coupling Reactions of Nitrogen Nucleophiles with Aryl Halides in Water
TL;DR: In this paper, a facile and practical strategy has been developed for the N-arylation of nitrogen nucleophiles with aryl halides catalyzed by a combination of iron(III) chloride [FeCl 3 ] and dimethylethylenediamine (dmeda) in water.
Journal ArticleDOI
Copper-catalyzed N-arylation of diazoles with aryl bromides using KF/Al2O3 : an improved protocol
TL;DR: In this article, a simple and efficient method for coupling aryl bromide with diazoles was proposed using air-stable CuI as a copper source and 1,10-phenanthroline in the presence of KF/Al 2 O 3 as a base.
Journal ArticleDOI
A facile and regioselective synthesis of rimonabant through an enamine-directed 1,3-dipolar cycloaddition
TL;DR: A novel, regioselective synthesis of rimonabant though an enamine-directed 1,3-dipolar cycloaddition and a new and more reactive hydrazonoyl halide for the generation of the requisite nitrile imine dipole are presented.
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