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From 2000 to mid-2010: a fruitful decade for the synthesis of pyrazoles.
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This article is published in Chemical Reviews.The article was published on 2011-08-01. It has received 839 citations till now.read more
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Design, Synthesis, In Vitro Evaluation and Docking Studies of Pyrazole‐Thiazole Hybrids as Antimicrobial and Antibiofilm Agents
Ramesh Gondru,K. Sirisha,Sneha Raj,Shravan Kumar Gunda,C. Ganesh Kumar,Mukesh Pasupuleti,Rajitha Bavantula +6 more
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Regioselective Synthesis, Antimicrobial Evaluation and QSAR Studies of Some 3‐Aryl‐1‐heteroarylindeno[1,2‐c]pyrazol‐4(1H)‐ones
Satbir Mor,Rajni Mohil,Savita Nagoria,Ashwani Kumar,Kashmiri Lal,Devinder Kumar,Virender Singh +6 more
TL;DR: The radial distribution function parameters were found to be important for description of activities against the modeled strains in quantitative structure–activity relationship studies.
Journal ArticleDOI
Cu-catalysed pyrazole synthesis in continuous flow
Júlia Comas-Barceló,Daniel Blanco-Ania,Sebastiaan A. M. W. van den Broek,Pieter J. Nieuwland,Joseph P. A. Harrity,Floris P. J. T. Rutjes +5 more
TL;DR: In this paper, the synthesis of 1,4-disubstituted pyrazoles via the cycloaddition reaction of sydnones and terminal alkynes has been achieved employing silica-supported copper catalysts.
Journal ArticleDOI
Synthetic Routes to 3(5)-Phosphonylated Pyrazoles
TL;DR: A review comprehensively covers the currently available synthetic routes to 3(5)-phosphonylated pyrazoles can be found in this article, where the potential of cyclocondensation of organophosphorus 1,3-dielectrophilic compounds with hydrazines is shown.
Journal ArticleDOI
Tandem synthesis of highly functionalized pyrazole derivatives from terminal alkynes, sulfonyl azides, diethyl azadicarboxylate, and sodium arylsulfinates
Issa Yavari,Manijeh Nematpour +1 more
TL;DR: The reaction between ketenimine intermediates, diethyl azadicarboxylate, and sodium arylsulfinates in N, N-dimethylformamide at room temperature affords ethyl 2,3-dihydro-3-oxo-4-phenyl-2-tosyl-5-(tosylamino)pyrazole-1-carboxylates in moderate-to-good yields.
References
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Recent developments in isocyanide based multicomponent reactions in applied chemistry
Journal ArticleDOI
Modern Synthetic Methods for Copper‐Mediated C(aryl) ? O, C(aryl) ? N, and C(aryl) ? S Bond Formation
Steven V. Ley,Andrew Thomas +1 more
TL;DR: In this article, the authors highlight the recent developments in the copper-mediated (both stoichiometric and catalytic) reactions of aryl boronic acids as reaction partners in both O- and N-arylation.
Journal ArticleDOI
Synthesis and biological evaluation of the 1,5-diarylpyrazole class of cyclooxygenase-2 inhibitors: identification of 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benze nesulfonamide (SC-58635, celecoxib).
T. D. Penning,John J. Talley,Bertenshaw,Jeffery S. Carter,P. W. Collins,Stephen H. Docter,Matthew J. Graneto,Len F. Lee,James W. Malecha,Julie M. Miyashiro,Roland S. Rogers,D. J. Rogier,Stella S. Yu,AndersonGD,E. G. Burton,J. N. Cogburn,Susan A. Gregory,Carol M. Koboldt,W E Perkins,Karen Seibert,A. W. Veenhuizen,Yan Y. Zhang,P. C. Isakson +22 more
TL;DR: 1i (4-[5-(4-methylphenyl)-3-(trifluoromethyl)- H-pyrazol-1-yl]benzenesulfonamide, SC-58635, celecoxib), which is currently in phase III clinical trials for the treatment of rheumatoid arthritis and osteoarthritis, is identified.
Journal ArticleDOI
Copper-mediated coupling reactions and their applications in natural products and designed biomolecules synthesis.
TL;DR: Using R-Hydroxy Stannanes as a Model for a Methylenation Reaction and Conclusions and Future Prospects are presented.
BookDOI
Synthetic applications of 1,3-dipolar cycloaddition chemistry toward heterocycles and natural products
Albert Padwa,William H. Pearson +1 more
TL;DR: In this paper, the authors present a list of the most important properties of Nitrones and Azomethine Ylides: Nitrones (Jason N. Martin and Raymond C. Jones), Nitronates (Scott E. Denmark and Jeromy J. Cottell), Azides (Chin-Kang Sha and A. K. Mohanakrishnan). Mesoionic Ring Systems (Gordon W. Gribble). Effect of External Reagents (Shuji Kanemasa). Asymmetric Reactions (Kurt Vesterager Gothe
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Synthesis and biological evaluation of the 1,5-diarylpyrazole class of cyclooxygenase-2 inhibitors: identification of 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benze nesulfonamide (SC-58635, celecoxib).
T. D. Penning,John J. Talley,Bertenshaw,Jeffery S. Carter,P. W. Collins,Stephen H. Docter,Matthew J. Graneto,Len F. Lee,James W. Malecha,Julie M. Miyashiro,Roland S. Rogers,D. J. Rogier,Stella S. Yu,AndersonGD,E. G. Burton,J. N. Cogburn,Susan A. Gregory,Carol M. Koboldt,W E Perkins,Karen Seibert,A. W. Veenhuizen,Yan Y. Zhang,P. C. Isakson +22 more