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From 2000 to mid-2010: a fruitful decade for the synthesis of pyrazoles.
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This article is published in Chemical Reviews.The article was published on 2011-08-01. It has received 839 citations till now.read more
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1H-1,2,4-diazaphospholes: Synthesis, structural characterization, and DFT calculation
Jun-Wen Wang,Ling-Yan Ding,Bing-Qiang Wang,Yao-Yun He,Yue Guo,Xue-Feng Jia,Wenjun Zheng,Wenjun Zheng +7 more
TL;DR: A few 1H-1,2,4-diazaphospholes H[3,5-R2dp] were prepared and structurally characterized by a substantial experimental modification of the synthetic protocol as mentioned in this paper.
Journal ArticleDOI
Preparation, properties, and reactivity of carbonylrhodium(I) complexes of di(2-pyrazolylaryl)amido-pincer ligands
TL;DR: In this paper, a series of six carbonylrhodium(I) complexes of three new and three previously reported di(2-3R-pyrazolyl)-p-Z/X-aryl)amido pincer ligands, (RZX)Rh(CO), (R is the substituent at the 3-pyraxolyl position proximal to the metal; Z and X are the aryl substituents para-to the ayrlamido nitrogen) were prepared.
Journal ArticleDOI
Ruthenium‐Catalyzed Site‐selective Enone Carbonyl Directed ortho‐C−H Activation of Aromatics and Heteroaromatics with Alkenes
Journal ArticleDOI
Divergent synthesis of spirocyclopentene-pyrazolones and pyrano[2,3-c]-pyrazoles via Lewis base controlled annulation reactions
TL;DR: In this article, an effective Lewis base catalyst-controlled α-regioselective annulation reaction of γ-substituted allenoates with unsaturated pyrazolones has been developed, affording various spirocyclopentene-pyrazolone and pyrano[2,3-c]pyrazoles.
Journal ArticleDOI
C(sp(3))-C(sp(3)) bond cleavage in the palladium-catalyzed aminohydroxylation of allylic hydrazones using atmospheric oxygen as the sole oxidant.
TL;DR: A C-C bond cleavage was observed in the palladium-catalyzed aminohydroxylation of allylic hydrazones, using atmospheric oxygen as the sole oxidant.
References
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Recent developments in isocyanide based multicomponent reactions in applied chemistry
Journal ArticleDOI
Modern Synthetic Methods for Copper‐Mediated C(aryl) ? O, C(aryl) ? N, and C(aryl) ? S Bond Formation
Steven V. Ley,Andrew Thomas +1 more
TL;DR: In this article, the authors highlight the recent developments in the copper-mediated (both stoichiometric and catalytic) reactions of aryl boronic acids as reaction partners in both O- and N-arylation.
Journal ArticleDOI
Synthesis and biological evaluation of the 1,5-diarylpyrazole class of cyclooxygenase-2 inhibitors: identification of 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benze nesulfonamide (SC-58635, celecoxib).
T. D. Penning,John J. Talley,Bertenshaw,Jeffery S. Carter,P. W. Collins,Stephen H. Docter,Matthew J. Graneto,Len F. Lee,James W. Malecha,Julie M. Miyashiro,Roland S. Rogers,D. J. Rogier,Stella S. Yu,AndersonGD,E. G. Burton,J. N. Cogburn,Susan A. Gregory,Carol M. Koboldt,W E Perkins,Karen Seibert,A. W. Veenhuizen,Yan Y. Zhang,P. C. Isakson +22 more
TL;DR: 1i (4-[5-(4-methylphenyl)-3-(trifluoromethyl)- H-pyrazol-1-yl]benzenesulfonamide, SC-58635, celecoxib), which is currently in phase III clinical trials for the treatment of rheumatoid arthritis and osteoarthritis, is identified.
Journal ArticleDOI
Copper-mediated coupling reactions and their applications in natural products and designed biomolecules synthesis.
TL;DR: Using R-Hydroxy Stannanes as a Model for a Methylenation Reaction and Conclusions and Future Prospects are presented.
BookDOI
Synthetic applications of 1,3-dipolar cycloaddition chemistry toward heterocycles and natural products
Albert Padwa,William H. Pearson +1 more
TL;DR: In this paper, the authors present a list of the most important properties of Nitrones and Azomethine Ylides: Nitrones (Jason N. Martin and Raymond C. Jones), Nitronates (Scott E. Denmark and Jeromy J. Cottell), Azides (Chin-Kang Sha and A. K. Mohanakrishnan). Mesoionic Ring Systems (Gordon W. Gribble). Effect of External Reagents (Shuji Kanemasa). Asymmetric Reactions (Kurt Vesterager Gothe
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Synthesis and biological evaluation of the 1,5-diarylpyrazole class of cyclooxygenase-2 inhibitors: identification of 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benze nesulfonamide (SC-58635, celecoxib).
T. D. Penning,John J. Talley,Bertenshaw,Jeffery S. Carter,P. W. Collins,Stephen H. Docter,Matthew J. Graneto,Len F. Lee,James W. Malecha,Julie M. Miyashiro,Roland S. Rogers,D. J. Rogier,Stella S. Yu,AndersonGD,E. G. Burton,J. N. Cogburn,Susan A. Gregory,Carol M. Koboldt,W E Perkins,Karen Seibert,A. W. Veenhuizen,Yan Y. Zhang,P. C. Isakson +22 more