Journal ArticleDOI
GABAergic Regulation of Adult Hippocampal Neurogenesis.
Mirjam Sibbe,Akos Kulik +1 more
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TLDR
A review of the roles of the inhibitory neurotransmitter γ-aminobutyric acid (GABA) in the proliferation and differentiation of stem cells and progenitor cells, as well as in the control of network activity of hippocampal stem cells, has been investigated.Abstract:
Adult hippocampal neurogenesis has been implicated in several brain functions, including learning and memory processes. It also plays an important role in the aetiology of anxiety disorders, depression and age-related deficits. The endogenous stem cell pool is also known to hold great potential for ameliorating the diseased or aged brain. It has been shown that certain brain activities lead to an adjustment of adult neurogenesis, which can further be controlled by the interplay between inhibitory and excitatory processes. The roles of the inhibitory neurotransmitter γ-aminobutyric acid (GABA) in the proliferation and differentiation of stem cells and progenitor cells, as well as in the control of network activity of hippocampal stem cells, have been extensively investigated in recent decades. This review highlights the general functions of GABAergic signalling and provides an exciting insight into the diverse functions of GABA in adult hippocampal stem cell biology.read more
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Factors that influence adult neurogenesis as potential therapy.
TL;DR: Critical analysis of the current understanding of the factors and molecular mechanisms that determine neurogenesis is provided and pre-clinical and clinical studies that have investigated the potential of modulating Neurogenesis as therapeutic intervention in neurodegeneration are discussed.
Journal ArticleDOI
Nutritional modulation of the intestinal microbiota; future opportunities for the prevention and treatment of neuroimmune and neuroinflammatory disease.
Vincent C. Lombardi,Vincent C. Lombardi,Kenny L. De Meirleir,Krishnamurthy Subramanian,Sam M. Nourani,Ruben K. Dagda,Shannon Delaney,András Palotás +7 more
TL;DR: The potential opportunities and challenges with respect to modifying and shaping the microbiota through diet and nutrition in order to treat or prevent neuroimmune and neuroinflammatory disease are discussed.
Journal ArticleDOI
Genetic and Metabolic Links Between the Murine Microbiome and Memory
Jian-Hua Mao,Young-Mo Kim,Yan-Xia Zhou,Yan-Xia Zhou,Dehong Hu,Chenhan Zhong,Hang Chang,Colin J. Brislawn,Sarah J. Fansler,Sasha A. Langley,Yunshan Wang,Yunshan Wang,B. Y. Loulou Peisl,Susan E. Celniker,David W. Threadgill,David W. Threadgill,Paul Wilmes,Galya Orr,Thomas O. Metz,Janet K. Jansson,Antoine M. Snijders +20 more
TL;DR: New evidence is provided for a link between Lactobacillus and memory and possible new avenues for treating memory impairment disorders using specific gut microbial inoculants and/or metabolites are opened.
Journal ArticleDOI
Endozepines and their receptors: Structure, functions and pathophysiological significance.
Marie-Christine Tonon,Hubert Vaudry,Julien Chuquet,Florent Guillebaud,Jinjiang Fan,Olfa Masmoudi-Kouki,David Vaudry,Damien Lanfray,Fabrice Morin,Vincent Prevot,Vassilios Papadopoulos,Jean-Denis Troadec,Jérôme Leprince +12 more
TL;DR: Current knowledge concerning the various actions of endozepines is reviewed and the physiopathological implications of these regulatory gliopeptides are discussed.
Journal ArticleDOI
KLHL3 Knockout Mice Reveal the Physiological Role of KLHL3 and the Pathophysiology of Pseudohypoaldosteronism Type II Caused by Mutant KLHL3
Emi Sasaki,Koichiro Susa,Takayasu Mori,Kiyoshi Isobe,Yuya Araki,Yuichi Inoue,Yuki Yoshizaki,Fumiaki Ando,Yutaro Mori,Shintaro Mandai,Moko Zeniya,Daiei Takahashi,Naohiro Nomura,Tatemitsu Rai,Shinichi Uchida,Eisei Sohara +15 more
TL;DR: KLHL3−/− mice were generated that expressed β-galactosidase (β-Gal) under the control of the endogenous KLHL3 promoter, indicating that autosomal dominant type PHAII is caused by the dominant negative effect of mutant KLHL2, and it is demonstrated that the dimerization of KLHL1 can explain this dominant negative effects.
References
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Journal ArticleDOI
Requirement of Hippocampal Neurogenesis for the Behavioral Effects of Antidepressants
Luca Santarelli,Michael Saxe,Cornelius Gross,Alexandre Surget,Fortunato Battaglia,Stephanie C. Dulawa,Noelia V. Weisstaub,James T. Lee,Ronald S. Duman,Ottavio Arancio,Catherine Belzung,René Hen +11 more
TL;DR: It is shown that disrupting antidepressant-induced neurogenesis blocks behavioral responses to antidepressants, suggesting that the behavioral effects of chronic antidepressants may be mediated by the stimulation of neuroGenesis in the hippocampus.
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Autoradiographic and histological evidence of postnatal hippocampal neurogenesis in rats
Joseph Altman,Gopal D. Das +1 more
TL;DR: It is postulated that undifferentiated cells migrate postnatally from the forebrain ventricles to the hippocampus where they become differentiated, implicating that they may function as receptors of gonadal hormones.
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Variations on an inhibitory theme : phasic and tonic activation of GABA(A) receptors
Mark Farrant,Zoltan Nusser +1 more
TL;DR: This review considers the distinct roles of synaptic and extrasynaptic GABA receptor subtypes in the control of neuronal excitability in the adult mammalian brain.
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New neurons and new memories: how does adult hippocampal neurogenesis affect learning and memory?
TL;DR: Recent progress in the integration of adult-born neurons into the circuitry of the adult hippocampus suggests an important role for adult hippocampal neurogenesis in learning and memory, but its specific function in these processes has remained elusive.
Journal ArticleDOI
Astrocytes Give Rise to New Neurons in the Adult Mammalian Hippocampus
TL;DR: It is shown that SGL cells, which express glial fibrillary acidic protein and have the characteristics of astrocytes, divide and generate new neurons under normal conditions or after the chemical removal of actively dividing cells.