Journal ArticleDOI
Gadolinium-coordinated elastic nanogels for in vivo tumor targeting and imaging.
Chang Keun Lim,Ajay Singh,Ajay Singh,Jeongyun Heo,Daehong Kim,Kyung Eun Lee,Hyesung Jeon,Joonseok Koh,Ick Chan Kwon,Sehoon Kim +9 more
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TLDR
Functional metal-organic coordinated nanogels (GdNGs) for in vivo tumor imaging are reported, whose non-crystalline and elastic nature allows for long blood circulation, as opposed to the rapid systemic clearance of common nanohybrids with rigid/ Crystalline frameworks.About:
This article is published in Biomaterials.The article was published on 2013-09-01. It has received 65 citations till now. The article focuses on the topics: Gadolinium.read more
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Stimuli-responsive nanogel composites and their application in nanomedicine
Maria Molina,Mazdak Asadian-Birjand,Juan Balach,Julian Bergueiro,Enrico Miceli,Marcelo Calderón +5 more
TL;DR: This review of nanogels, particularly in the form of composites or hybrids applied in nanomedicine, will describe nanosized crosslinked polymer networks capable of absorbing large quantities of water.
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Nanogels: An overview of properties, biomedical applications and obstacles to clinical translation.
TL;DR: This review aims to highlight the distinct and unique capabilities of nanogels as carrier systems for the delivery of an array of cargo molecules over other nanomaterials and made an attempt to highlight some of the major challenges that need to be overcome to advance nanogel further in the field of biomedical applications.
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Self-assembled nanoscale coordination polymers with trigger release properties for effective anticancer therapy
TL;DR: This study establishes NCPs as a promising drug delivery platform for cancer therapy by using them as nanotherapeutics with enhanced antitumor activities and reports the self-assembly of zinc bisphosphonate N CPs that carry 48±3 wt% cisplatin prodrug and 45±5 wt%.
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Carbon-based hybrid nanogels: a synergistic nanoplatform for combined biosensing, bioimaging, and responsive drug delivery
TL;DR: A vast number of studies have been pursued to explore the applications of carbon-based hybrid nanogels in biomedical areas for biosensing, bioimaging, and smart drug carriers with combinatorial therapies and/or theranostic ability.
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Hydrogel-Based Controlled Drug Delivery for Cancer Treatment: A Review
TL;DR: The different sizes of hydrogels used for cancer treatment and their related delivery routes are summarized, the design strategies for stimuli-responsive hydrogELs are discussed, and the research concerning smart hydrogel reported in the past few years is reviewed.
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A New Concept for Macromolecular Therapeutics in Cancer Chemotherapy: Mechanism of Tumoritropic Accumulation of Proteins and the Antitumor Agent Smancs
Yasuhiro Matsumura,Hiroshi Maeda +1 more
TL;DR: It is speculated that the tumoritropic accumulation of smancs and other proteins resulted because of the hypervasculature, an enhanced permeability to even macromolecules, and little recovery through either blood vessels or lymphatic vessels in tumors of tumor-bearing mice.
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Cancer nanotechnology: opportunities and challenges.
TL;DR: Nanotechnology is a multidisciplinary field, which covers a vast and diverse array of devices derived from engineering, biology, physics and chemistry that can provide essential breakthroughs in the fight against cancer.
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Gadolinium(III) Chelates as MRI Contrast Agents: Structure, Dynamics, and Applications
TL;DR: A. Relaxivity 2331 E. Outerand Second-Sphere relaxivity 2334 F. Methods of Improving Relaxivity 2336 V. Macromolecular Conjugates 2336.
Journal ArticleDOI
Renal clearance of quantum dots.
Hak Soo Choi,Wenhao Liu,Preeti Misra,Eiichi Tanaka,John P. Zimmer,Binil Itty Ipe,Moungi G. Bawendi,John V. Frangioni,John V. Frangioni +8 more
TL;DR: This study has precisely defined the requirements for renal filtration and urinary excretion of inorganic, metal-containing nanoparticles and provides a foundation for the design and development of biologically targeted nanoparticles for biomedical applications.
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Nanoscale Metal–Organic Frameworks for Biomedical Imaging and Drug Delivery
TL;DR: Although still at a very early stage of development, NMOFs have already shown great promise as a novel platform for nanomedicine and should allow for the incorporation of other imaging and therapeutic agents and their effective delivery to targeted cells in vivo.