Gamma oscillations in somatosensory cortex recruit prefrontal and descending serotonergic pathways in aversion and nociception
Linette Liqi Tan,Manfred J. Oswald,Céline Heinl,Oscar Andrés Retana Romero,Sanjeev Kumar Kaushalya,Hannah Monyer,Rohini Kuner +6 more
TLDR
Evidence in mice is provided that gamma oscillations causally contribute to pain perception, and a mechanistic framework for modulation of pain by specific activity patterns in the S1 cortex is described.Abstract:
In humans, gamma-band oscillations in the primary somatosensory cortex (S1) correlate with subjective pain perception. However, functional contributions to pain and the nature of underlying circuits are unclear. Here we report that gamma oscillations, but not other rhythms, are specifically strengthened independently of any motor component in the S1 cortex of mice during nociception. Moreover, mice with inflammatory pain show elevated resting gamma and alpha activity and increased gamma power in response to sub-threshold stimuli, in association with behavioral nociceptive hypersensitivity. Inducing gamma oscillations via optogenetic activation of parvalbumin-expressing inhibitory interneurons in the S1 cortex enhances nociceptive sensitivity and induces aversive avoidance behavior. Activity mapping identified a network of prefrontal cortical and subcortical centers whilst morphological tracing and pharmacological studies demonstrate the requirement of descending serotonergic facilitatory pathways in these pain-related behaviors. This study thus describes a mechanistic framework for modulation of pain by specific activity patterns in the S1 cortex. Gamma oscillations in somatosensory areas in humans correlate with pain perception and pain stimulus intensity, but could also reflect cognitive processes such as attention. Here the authors provide evidence in mice that these oscillations causally contribute to pain perception.read more
Citations
More filters
Journal ArticleDOI
Haplotype-resolved diverse human genomes and integrated analysis of structural variation.
Peter Ebert,Peter A. Audano,Qihui Zhu,Bernardo Rodriguez-Martin,David Porubsky,Marc Jan Bonder,Marc Jan Bonder,Arvis Sulovari,Jana Ebler,Weichen Zhou,Rebecca Serra Mari,Feyza Yilmaz,Xuefang Zhao,Xuefang Zhao,PingHsun Hsieh,Joyce V. Lee,Sushant Kumar,Jiadong Lin,Tobias Rausch,Yu Chen,Jingwen Ren,Martin Santamarina,Wolfram Höps,Hufsah Ashraf,Nelson T. Chuang,Xiaofei Yang,Katherine M. Munson,Alexandra P. Lewis,Susan Fairley,Luke J. Tallon,Wayne E. Clarke,Anna O. Basile,Marta Byrska-Bishop,André Corvelo,Uday S. Evani,Tsung Yu Lu,Mark Chaisson,Junjie Chen,Chong Li,Harrison Brand,Harrison Brand,Aaron M. Wenger,Maryam Ghareghani,Maryam Ghareghani,Maryam Ghareghani,William T. Harvey,Benjamin Raeder,Patrick Hasenfeld,Allison A. Regier,Haley J. Abel,Ira M. Hall,Paul Flicek,Oliver Stegle,Oliver Stegle,Mark Gerstein,Jose M. C. Tubio,Zepeng Mu,Yang I. Li,Xinghua Shi,Alex Hastie,Kai Ye,Kai Ye,Zechen Chong,Ashley D. Sanders,Michael C. Zody,Michael E. Talkowski,Michael E. Talkowski,Ryan E. Mills,Scott E. Devine,Charles Lee,Charles Lee,Jan O. Korbel,Tobias Marschall,Evan E. Eichler +73 more
TL;DR: In this article, the authors present 64 assembled haplotypes from 32 diverse human genomes, which integrate all forms of genetic variation, even across complex loci, and identify 107,590 structural variants (SVs), of which 68% were not discovered with short-read sequencing.
Journal ArticleDOI
Cellular Circuits in the Brain and Their Modulation in Acute and Chronic Pain.
Rohini Kuner,Thomas Kuner +1 more
TL;DR: This review aims to discuss recent advances in the understanding of circuit connectivity in the mammalian brain at the level of regional contributions and specific cell types in acute and chronic pain.
Journal ArticleDOI
Mapping Cortical Integration of Sensory and Affective Pain Pathways.
Amrita Singh,Divya Patel,Anna Li,Lizbeth Hu,Qiaosheng Zhang,Yaling Liu,Xinling Guo,Eric Robinson,Erik Martinez,Lisa Doan,Bernardo Rudy,Zhe Chen,Jing Wang +12 more
TL;DR: It is found that a subset of neurons in the ACC receives S1 inputs, and activation of the S1 axon terminals increases the response to noxious stimuli in ACC neurons, which defines a cortical circuit that plays a potentially important role in integrating sensory and affective pain signals.
Journal ArticleDOI
Diversity and function of corticopetal and corticofugal GABAergic projection neurons
Sarah Melzer,Hannah Monyer +1 more
TL;DR: Increasing evidence indicates that some cortical neurons that send long-range projections to distant brain regions are GABAergic, and Melzer and Monyer examine recent progress in the identification and function of these neurons.
Journal ArticleDOI
Neocortical circuits in pain and pain relief.
Linette Liqi Tan,Rohini Kuner +1 more
TL;DR: Kuner and Tan as mentioned in this paper discuss new insights into the contributions of diverse cerebral domains, their connectivity and their plasticity to the sensory and emotional aspects of pain, and provide opportunities for therapeutic intervention for improved pain management.
References
More filters
Journal ArticleDOI
Brainstorm: a user-friendly application for MEG/EEG analysis
TL;DR: Brainstorm as discussed by the authors is a collaborative open-source application dedicated to magnetoencephalography (MEG) and EEG data visualization and processing, with an emphasis on cortical source estimation techniques and their integration with anatomical magnetic resonance imaging (MRI) data.
Journal ArticleDOI
Driving fast-spiking cells induces gamma rhythm and controls sensory responses
Jessica A. Cardin,Marie Carlén,Marie Carlén,Konstantinos Meletis,Konstantinos Meletis,Ulf Knoblich,Feng Zhang,Karl Deisseroth,Li-Huei Tsai,Li-Huei Tsai,Li-Huei Tsai,Christopher I. Moore +11 more
TL;DR: The timing of a sensory input relative to a gamma cycle determined the amplitude and precision of evoked responses and provided the first causal evidence that distinct network activity states can be induced in vivo by cell-type-specific activation.
Journal ArticleDOI
Parvalbumin neurons and gamma rhythms enhance cortical circuit performance
TL;DR: Optogenetics opens the door to a new kind of informational analysis of brain function, permitting quantitative delineation of the functional significance of individual elements in the emergent operation and function of intact neural circuitry.
Journal ArticleDOI
How Inhibition Shapes Cortical Activity
TL;DR: Current views of how inhibition regulates the function of cortical neurons are discussed, and a number of important open questions are pointed to.
Journal ArticleDOI
The use of c-fos as a metabolic marker in neuronal pathway tracing.
Mike Dragunow,Richard L.M. Faull +1 more
TL;DR: The use of c-fos protein (Fos) immunocytochemistry as a metabolic marker for tracing neuroanatomical connections, seizure pathways and sites of action of neuroactive drugs is discussed in this report.