Genomic predictors of the maximal O2 uptake response to standardized exercise training programs
Claude Bouchard,Mark A. Sarzynski,Treva Rice,William E. Kraus,Timothy S. Church,Yun Ju Sung,D. C. Rao,Tuomo Rankinen +7 more
TLDR
These genomic predictors of the response of Vo(2max) to regular exercise provide new targets for the study of the biology of fitness and its adaptation to regular Exercise.Abstract:
Low cardiorespiratory fitness is a powerful predictor of morbidity and cardiovascular mortality. In 473 sedentary adults, all whites, from 99 families of the Health, Risk Factors, Exercise Training...read more
Citations
More filters
Journal ArticleDOI
Importance of Assessing Cardiorespiratory Fitness in Clinical Practice: A Case for Fitness as a Clinical Vital Sign: A Scientific Statement From the American Heart Association.
Robert Ross,Steven N. Blair,Ross Arena,Timothy S. Church,Jean-Pierre Després,Barry A. Franklin,William L. Haskell,Leonard A. Kaminsky,Benjamin D. Levine,Carl J. Lavie,Jonathan Myers,Josef Niebauer,Robert E. Sallis,Susumu S. Sawada,Xuemei Sui,Ulrik Wisløff +15 more
TL;DR: The addition of CRF for risk classification presents health professionals with unique opportunities to improve patient management and to encourage lifestyle-based strategies designed to reduce cardiovascular risk to meet the American Heart Association’s 2020 goals.
Journal ArticleDOI
An official American Thoracic Society/European Respiratory Society statement: update on limb muscle dysfunction in chronic obstructive pulmonary disease
François Maltais,Marc Decramer,Richard Casaburi,Esther Barreiro,Yan Burelle,Richard Debigaré,P. N. Richard Dekhuijzen,Frits M.E. Franssen,Ghislaine Gayan-Ramirez,Joaquim Gea,Harry R. Gosker,Rik Gosselink,Maurice Hayot,Sabah N. A. Hussain,Wim Janssens,Micheal I. Polkey,Josep Roca,Didier Saey,Annemie M. W. J. Schols,Martijn A. Spruit,Michael C Steiner,Tanja Taivassalo,Thierry Troosters,Ioannis Vogiatzis,Peter D. Wagner +24 more
TL;DR: The purpose of this document is to update the 1999 ATS/ERS statement on limb muscle dysfunction in COPD with important advances in the understanding of the extent and nature of the structural alterations in limb muscles in patients with COPD.
Journal ArticleDOI
Do “Brain-Training” Programs Work?:
Daniel J. Simons,Walter R. Boot,Neil Charness,Susan E. Gathercole,Christopher F. Chabris,David Z. Hambrick,Elizabeth A. L. Stine-Morrow +6 more
TL;DR: Extensive evidence that brain-training interventions improve performance on the trained tasks, less evidence that such interventions improved performance on closely related tasks, and little evidence that training enhances performance on distantly related tasks or that training improves everyday cognitive performance are found.
Journal ArticleDOI
Sedentary Behavior, Exercise, and Cardiovascular Health.
TL;DR: The prognostic utility of cardiorespiratory fitness compared with obesity and the metabolic syndrome is reviewed, as well as the increase of physical activity /ET for patients with heart failure as a therapeutic strategy, and ET dosing.
Journal ArticleDOI
Regulation of Increased Blood Flow (Hyperemia) to Muscles During Exercise: A Hierarchy of Competing Physiological Needs
TL;DR: The idea is that blood flow to the contracting muscle links oxygen in the atmosphere with the contracting muscles where it is consumed in order to link oxygen with the muscle, and the vasodilating factors in the muscle are responsible for these very high flows.
References
More filters
Journal ArticleDOI
Exercise Capacity and Mortality in Older Men A 20-Year Follow-Up Study
Peter Kokkinos,Jonathan Myers,Charles Faselis,Demosthenes B. Panagiotakos,Michael Doumas,Andreas Pittaras,Athanasios J. Manolis,John Peter Kokkinos,Pamela Karasik,Michael Greenberg,Vasilios Papademetriou,Ross D. Fletcher +11 more
TL;DR: Exercise capacity is an independent predictor of all-cause mortality in older men, with most survival benefits achieved in those with an exercise capacity >5 METs, and survival improved significantly when unfit individuals became fit.
Journal ArticleDOI
Genetics of aerobic and anaerobic performances.
Journal ArticleDOI
Age, sex, race, initial fitness, and response to training: the HERITAGE Family Study.
James S. Skinner,Artur Jaskólski,Anna Jaskólska,Joanne B. Krasnoff,Jacques Gagnon,Arthur S. Leon,D. C. Rao,Jack H. Wilmore,Claude Bouchard +8 more
TL;DR: Age, sex, race, and initial fitness have little influence on VO(2 max) response to standardized training in a large heterogeneous sample of sedentary black and white men and women.
Journal ArticleDOI
Genomic scan for maximal oxygen uptake and its response to training in the HERITAGE Family Study.
Claude Bouchard,Tuomo Rankinen,Yvon C. Chagnon,Treva Rice,Louis Pérusse,Jacques Gagnon,Ingrid B. Borecki,Ping An,Arthur S. Leon,James S. Skinner,Jack H. Wilmore,Michael A. Province,Dabeeru C. Rao +12 more
TL;DR: Results indicate that linkages at P values of 0.01 and better are observed with markers on 4q, 8q, 11p, and 14q for VO(2 max) before training and with markers for the change in VO( 2 max) in response to a 20-wk standardized endurance training program.
Journal ArticleDOI
Sensitivity of maximal aerobic power to training is genotype-dependent.
TL;DR: The results suggest that there are considerable individual differences in the adaptive capacity to short-term endurance training, and sensitivity of maximal aerobic power to such training is largely genotype-dependent.
Related Papers (5)
Using molecular classification to predict gains in maximal aerobic capacity following endurance exercise training in humans.
James A. Timmons,James A. Timmons,Steen Knudsen,Tuomo Rankinen,Lauren G. Koch,Mark A. Sarzynski,Thomas Jensen,Pernille Keller,Pernille Keller,Camilla Scheele,Camilla Scheele,Niels B. J. Vollaard,Søren Nielsen,Thorbjorn Akerstrom,Ormond A. MacDougald,Eva Jansson,Paul L. Greenhaff,Mark A. Tarnopolsky,Luc J. C. van Loon,Bente Klarlund Pedersen,Carl Johan Sundberg,Claes Wahlestedt,Steven L. Britton,Claude Bouchard +23 more
Individual differences in response to regular physical activity.
Claude Bouchard,Tuomo Rankinen +1 more