Genomic predictors of the maximal O2 uptake response to standardized exercise training programs
Claude Bouchard,Mark A. Sarzynski,Treva Rice,William E. Kraus,Timothy S. Church,Yun Ju Sung,D. C. Rao,Tuomo Rankinen +7 more
TLDR
These genomic predictors of the response of Vo(2max) to regular exercise provide new targets for the study of the biology of fitness and its adaptation to regular Exercise.Abstract:
Low cardiorespiratory fitness is a powerful predictor of morbidity and cardiovascular mortality. In 473 sedentary adults, all whites, from 99 families of the Health, Risk Factors, Exercise Training...read more
Citations
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The Limits of Exercise Physiology: From Performance to Health.
TL;DR: Some of the historical milestones of exercise physiology are reviewed, how these inform contemporary knowledge, and speculate on future questions are discussed.
Journal ArticleDOI
Do Non-Responders to Exercise Exist—and If So, What Should We Do About Them?
Craig Pickering,John Kiely +1 more
TL;DR: It is suggested that it is unlikely that global non-responders to exercise exist, and this insight serves to encourage health professionals to create more nuanced, efficacious, and individually-focused exercise prescriptions designed to circumvent and overcome apparent non-responsiveness.
Journal ArticleDOI
Genes to predict VO2max trainability: a systematic review
Camilla J. Williams,Mark Williams,Nir Eynon,Kevin J. Ashton,Jonathan P. Little,Ulrik Wisløff,Ulrik Wisløff,Jeff S. Coombes +7 more
TL;DR: Ninety-seven genes have been identified as possible predictors of VO2max trainability and to identify if there are more genetic variants and/or mediators, further tightly-controlled studies that measure a range of biomarkers across ethnicities are required.
Journal ArticleDOI
Dose–response relationship of cardiorespiratory fitness adaptation to controlled endurance training in sedentary older adults
Guoyuan Huang,Guoyuan Huang,Ru Wang,Peijie Chen,Sunny C Huang,Sunny C Huang,Joseph E. Donnelly,Jon P Mehlferber +7 more
TL;DR: The authors' data provide quantitative insight into the magnitude of VO2max alterations as affected by exercise intensity, duration, frequency, and program length, and the shapes of the dose–response curves are not simply linear, but with many similar trends and noteworthy characteristics.
Journal ArticleDOI
Twin-sibling study and meta-analysis on the heritability of maximal oxygen consumption
Nienke M. Schutte,Nienke M. Schutte,Ineke Nederend,Ineke Nederend,James J. Hudziak,Meike Bartels,Meike Bartels,Eco J. C. de Geus,Eco J. C. de Geus +8 more
TL;DR: The authors found that large individual differences exist in aerobic fitness in childhood and adolescence, but the relative contribution of genetic factors to this variation remains to be established. In a sample of adol...
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TL;DR: By combining genome-wide association data from 8,130 individuals with type 2 diabetes and 38,987 controls of European descent and following up previously unidentified meta-analysis signals, 12 new T2D association signals are identified with combined P < 5 × 10−8.
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