Genomic predictors of the maximal O2 uptake response to standardized exercise training programs
Claude Bouchard,Mark A. Sarzynski,Treva Rice,William E. Kraus,Timothy S. Church,Yun Ju Sung,D. C. Rao,Tuomo Rankinen +7 more
TLDR
These genomic predictors of the response of Vo(2max) to regular exercise provide new targets for the study of the biology of fitness and its adaptation to regular Exercise.Abstract:
Low cardiorespiratory fitness is a powerful predictor of morbidity and cardiovascular mortality. In 473 sedentary adults, all whites, from 99 families of the Health, Risk Factors, Exercise Training...read more
Citations
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A Prospective Study of Cardiorespiratory Fitness and Risk of Type 2 Diabetes in Women: 667
Steven P. Hooker,Mei Sui,I-Min Lee,Timothy S. Church,Natalie Colabianchi,Chong D. Lee,Steven N. Blair +6 more
TL;DR: Low CRF and higher BMI were independently associated with incident type 2 diabetes and the protective effect of CRF was observed in individuals who were overweight or obese, but CRF did not eliminate the increased risk in these groups.
Journal ArticleDOI
Can we optimise the exercise training prescription to maximise improvements in mitochondria function and content
TL;DR: The results of cross-sectional studies, as well as training studies involving rats and humans, suggest that training intensity may be an important determinant of improvements in mitochondrial function, but not mitochondrial content.
Journal ArticleDOI
Skeletal Muscle Dysfunction in Chronic Obstructive Pulmonary Disease. What We Know and Can Do for Our Patients
Ariel Jaitovich,Esther Barreiro +1 more
TL;DR: A general overview of skeletal muscle dysfunction in COPD is offered to highlight its relevance and magnitude to expert practitioners and scientists as well as to the average clinician dealing with patients with chronic respiratory diseases.
Journal ArticleDOI
Dose-Response of Aerobic Exercise on Cognition: A Community-Based, Pilot Randomized Controlled Trial
Eric D. Vidoni,David K. Johnson,Jill K. Morris,Angela Van Sciver,Colby S. Greer,Sandra A. Billinger,Joseph E. Donnelly,Jeffrey M. Burns +7 more
TL;DR: Cognitive benefits were apparent at low doses with possible increased benefits in visuospatial function at higher doses but only in those who adhered to the exercise protocol, and an individual's cardiorespiratory fitness response was a better predictor of cognitive gains than exercise dose and thus maximizing an individual’s cardiorespiratory fitness may be an important therapeutic target for achieving cognitive benefits.
Journal ArticleDOI
Genomic predictors of trainability.
TL;DR: Evidence was found in support of a strong genotype dependency of the ability to respond to regular exercise and a genomic predictor score based on the number of favourable alleles carried at 21 single nucleotide polymorphisms appears to be able to identify low and high training response classes that differ by at least threefold.
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TL;DR: By combining genome-wide association data from 8,130 individuals with type 2 diabetes and 38,987 controls of European descent and following up previously unidentified meta-analysis signals, 12 new T2D association signals are identified with combined P < 5 × 10−8.
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