Genomic predictors of the maximal O2 uptake response to standardized exercise training programs
Claude Bouchard,Mark A. Sarzynski,Treva Rice,William E. Kraus,Timothy S. Church,Yun Ju Sung,D. C. Rao,Tuomo Rankinen +7 more
TLDR
These genomic predictors of the response of Vo(2max) to regular exercise provide new targets for the study of the biology of fitness and its adaptation to regular Exercise.Abstract:
Low cardiorespiratory fitness is a powerful predictor of morbidity and cardiovascular mortality. In 473 sedentary adults, all whites, from 99 families of the Health, Risk Factors, Exercise Training...read more
Citations
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The Pleiotropic Effect of Physical Exercise on Mitochondrial Dynamics in Aging Skeletal Muscle
Elena Barbieri,Deborah Agostini,Emanuela Polidori,Lucia Potenza,Michele Guescini,Francesco Lucertini,Giosuè Annibalini,Laura Stocchi,Mauro De Santi,Vilberto Stocchi +9 more
TL;DR: Combined physical activity programs should be individually prescribed to maximize the antiaging effects of exercise, due to the different effect of both exercises in improving mitochondrial content and quality.
Journal ArticleDOI
Advances in exercise, fitness, and performance genomics in 2011.
Stephen M. Roth,Tuomo Rankinen,James M. Hagberg,Ruth J. F. Loos,Louis Pérusse,Mark A. Sarzynski,Bernd Wolfarth,Claude Bouchard +7 more
TL;DR: It is concluded that a strong exercise genomics corpus of evidence would not only translate into powerful genomic predictors but also have a major effect on exercise biology and exercise behavior research.
Journal ArticleDOI
Physiological Differences Between Low Versus High Skeletal Muscle Hypertrophic Responders to Resistance Exercise Training: Current Perspectives and Future Research Directions.
Michael D. Roberts,Cody T. Haun,Christopher B. Mobley,Petey W. Mumford,Matthew A. Romero,Paul A. Roberson,Christopher G. Vann,John J. McCarthy +7 more
TL;DR: Other molecular and physiological variables which could potentially affect the skeletal muscle hypertrophic response to resistance exercise training are also discussed including rDNA copy number, extracellular matrix and connective tissue properties, the inflammatory response to training, and mitochondrial as well as vascular characteristics.
Journal ArticleDOI
Inter-Individual Responses of Maximal Oxygen Uptake to Exercise Training: A Critical Review
TL;DR: In this paper, a literature search through the relevant bibliographic databases resulted in the identification of six relevant studies that were published prior to the influential HEalth, RIsk factors, exercise Training And GEnetics (HERITAGE) Family Study.
Journal ArticleDOI
Genome-wide association study identifies three novel genetic markers associated with elite endurance performance
Ildus I. Ahmetov,Nickolay A. Kulemin,Daniil V. Popov,Vladimir Naumov,Egor B. Akimov,Yan R. Bravy,Emiliya S. Egorova,Albina A Galeeva,Edward V. Generozov,Elena S. Kostryukova,Andrey K. Larin,Leysan J. Mustafina,Elena A. Ospanova,Alexander V. Pavlenko,Linda M. Starnes,Piotr Żmijewski,Dmitry G. Alexeev,Olga Vinogradova,Vadim M. Govorun +18 more
TL;DR: The data show that the NFIA-AS2 rs1572312, TSHR rs7144481 and RBFOX1 rs7191721 polymorphisms are associated with aerobic performance and elite endurance athlete status.
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TL;DR: By combining genome-wide association data from 8,130 individuals with type 2 diabetes and 38,987 controls of European descent and following up previously unidentified meta-analysis signals, 12 new T2D association signals are identified with combined P < 5 × 10−8.
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