Genomic predictors of the maximal O2 uptake response to standardized exercise training programs
Claude Bouchard,Mark A. Sarzynski,Treva Rice,William E. Kraus,Timothy S. Church,Yun Ju Sung,D. C. Rao,Tuomo Rankinen +7 more
TLDR
These genomic predictors of the response of Vo(2max) to regular exercise provide new targets for the study of the biology of fitness and its adaptation to regular Exercise.Abstract:
Low cardiorespiratory fitness is a powerful predictor of morbidity and cardiovascular mortality. In 473 sedentary adults, all whites, from 99 families of the Health, Risk Factors, Exercise Training...read more
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Journal Article
Biomotricity roundtable-genômica e fisiologia molecular do exercício e do esporte
André Katayama Yamada,Romulo Bertuzzi,Tiago Costa Leite,Jonato Prestes,Carlos Roberto Bueno Júnior +4 more
TL;DR: Yamada, A. K., Bertuzzi, R., Leite, T.C., Prestes, J., Junior, C.B. as mentioned in this paper, Biomotricity Roundtable - genomica e fisiologia molecular do exercicio e do esporte
Journal ArticleDOI
Common protein-coding variants influence the racing phenotype in galloping racehorse breeds
Haige Han,Beatrice A. McGivney,Lucy Allen,Dongyi Bai,Leanne R. Corduff,Gantulga Davaakhuu,Jargalsaikhan Davaasambuu,Dulguun Dorjgotov,Thomas J. Hall,A. Hemmings,Amy R Holtby,Tuyatsetseg Jambal,Badarch Jargalsaikhan,Uyasakh Jargalsaikhan,Naveen Kumar Kadri,David E. MacHugh,Hubert Pausch,Carol Readhead,David Warburton,Manglai Dugarjaviin,Emmeline W. Hill +20 more
TL;DR: This paper identified genes contributing to exercise adaptation in racehorses by applying genomics approaches for racing performance, an end-point athletic phenotype, using an integrative genomics strategy to first combine population genomics results with skeletal muscle exercise and training transcriptomic data, followed by whole-genome resequencing of Asian horses.
Dissertation
Unraveling the genetic components of voluntary exercise behavior in adolescents and young adults
Dissertation
Regulation of SIRT1, SIRT3, PGC-1α, and LRP130 in Response to Energetic Stress in Human Skeletal Muscle
TL;DR: The present work focuses on the development of a novel regulator of mitochondrial-encoded gene expression, LRP130, in skeletal muscle during acute and chronic exercise and its role in regulating whole-body metabolism.
Journal ArticleDOI
Associations among cardiorespiratory fitness, C-reactive protein, and all-cause mortality in men and women
Stephen W. Farrell,David Leonard,Carolyn E. Barlow,Kerem Shuval,Andjelka Pavlovic,Kenneth H. Cooper,Laura F. DeFina +6 more
TL;DR: In this paper , individual and joint associations among high-sensitivity C-reactive protein (CRP), cardiorespiratory fitness (fitness), and mortality in healthy men and women were examined.
References
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Changes in Physical Fitness and All-Cause Mortality: A Prospective Study of Healthy and Unhealthy Men
Steven N. Blair,Harold W. Kohl,Carolyn E. Barlow,Ralph S. Paffenbarger,Larry W. Gibbons,Caroline A. Macera +5 more
TL;DR: Men who maintained or improved adequate physical fitness were less likely to die from all causes and from cardiovascular disease during follow-up than persistently unfit men.
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Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis
Benjamin F. Voight,Benjamin F. Voight,Laura J. Scott,Valgerdur Steinthorsdottir,Andrew P. Morris,Christian Dina,Christian Dina,Ryan P. Welch,Eleftheria Zeggini,Eleftheria Zeggini,Cornelia Huth,Yurii S. Aulchenko,Gudmar Thorleifsson,Laura J. McCulloch,Teresa Ferreira,Harald Grallert,Najaf Amin,Guanming Wu,Cristen J. Willer,Soumya Raychaudhuri,Soumya Raychaudhuri,Soumya Raychaudhuri,Steve McCarroll,Steve McCarroll,Claudia Langenberg,Oliver Hofmann,Josée Dupuis,Lu Qi,Lu Qi,Ayellet V. Segrè,Ayellet V. Segrè,Mandy van Hoek,Pau Navarro,Kristin Ardlie,Beverley Balkau,Rafn Benediktsson,Amanda J. Bennett,Roza Blagieva,Eric Boerwinkle,Lori L. Bonnycastle,Kristina Bengtsson Boström,Bert Bravenboer,Suzannah Bumpstead,N P Burtt,Guillaume Charpentier,Peter S. Chines,Marilyn C. Cornelis,David Couper,Gabe Crawford,Alex S. F. Doney,Katherine S. Elliott,Amanda F. Elliott,Amanda F. Elliott,Michael R. Erdos,Caroline S. Fox,Christopher S. Franklin,Martha Ganser,Christian Gieger,Niels Grarup,Todd Green,Todd Green,Simon J. Griffin,Christopher J. Groves,Candace Guiducci,Samy Hadjadj,Neelam Hassanali,Christian Herder,Bo Isomaa,Anne U. Jackson,Paul Johnson,Torben Jørgensen,Torben Jørgensen,Wen H. L. Kao,Norman Klopp,Augustine Kong,Peter Kraft,Johanna Kuusisto,Torsten Lauritzen,Man Li,Aloysius G Lieverse,Cecilia M. Lindgren,Valeriya Lyssenko,Michel Marre,Michel Marre,Thomas Meitinger,Kristian Midthjell,Mario A. Morken,Narisu Narisu,Peter M. Nilsson,Katharine R. Owen,Felicity Payne,John R. B. Perry,Ann-Kristin Petersen,Carl G. P. Platou,Christine Proença,Inga Prokopenko,Inga Prokopenko,Wolfgang Rathmann,N. William Rayner,N. William Rayner,Neil R. Robertson,Neil R. Robertson,Ghislain Rocheleau,Michael Roden,Mike Sampson,Richa Saxena,Richa Saxena,Beverley M. Shields,Peter Shrader,Gunnar Sigurdsson,Thomas Sparsø,Klaus Strassburger,Heather M. Stringham,Qi Sun,Amy J. Swift,Barbara Thorand,Jean Tichet,Tiinamaija Tuomi,Rob M. van Dam,Timon W. van Haeften,Thijs T. W. van Herpt,Jana V. van Vliet-Ostaptchouk,G. Bragi Walters,Michael N. Weedon,Cisca Wijmenga,Jacqueline C. M. Witteman,Richard N. Bergman,Stéphane Cauchi,Francis S. Collins,Anna L. Gloyn,Ulf Gyllensten,Torben Hansen,Winston Hide,Graham A. Hitman,Albert Hofman,David J. Hunter,Kristian Hveem,Markku Laakso,Karen L. Mohlke,Andrew D. Morris,Colin N. A. Palmer,Peter P. Pramstaller,Igor Rudan,Igor Rudan,Eric J.G. Sijbrands,Lincoln Stein,Jaakko Tuomilehto,Jaakko Tuomilehto,André G. Uitterlinden,Mark Walker,Nicholas J. Wareham,Richard M. Watanabe,Gonçalo R. Abecasis,Bernhard O. Boehm,Harry Campbell,Mark J. Daly,Mark J. Daly,Andrew T. Hattersley,Frank B. Hu,Frank B. Hu,James B. Meigs,James S. Pankow,Oluf Pedersen,H-Erich Wichmann,Inês Barroso,Jose C. Florez,Timothy M. Frayling,Leif Groop,Leif Groop,Robert Sladek,Unnur Thorsteinsdottir,Unnur Thorsteinsdottir,James F. Wilson,Thomas Illig,Philippe Froguel,Philippe Froguel,Cornelia M. van Duijn,Kari Stefansson,Kari Stefansson,David Altshuler,Michael Boehnke,Mark I. McCarthy,Mark I. McCarthy,Mark I. McCarthy +183 more
TL;DR: By combining genome-wide association data from 8,130 individuals with type 2 diabetes and 38,987 controls of European descent and following up previously unidentified meta-analysis signals, 12 new T2D association signals are identified with combined P < 5 × 10−8.
Related Papers (5)
Using molecular classification to predict gains in maximal aerobic capacity following endurance exercise training in humans.
James A. Timmons,James A. Timmons,Steen Knudsen,Tuomo Rankinen,Lauren G. Koch,Mark A. Sarzynski,Thomas Jensen,Pernille Keller,Pernille Keller,Camilla Scheele,Camilla Scheele,Niels B. J. Vollaard,Søren Nielsen,Thorbjorn Akerstrom,Ormond A. MacDougald,Eva Jansson,Paul L. Greenhaff,Mark A. Tarnopolsky,Luc J. C. van Loon,Bente Klarlund Pedersen,Carl Johan Sundberg,Claes Wahlestedt,Steven L. Britton,Claude Bouchard +23 more
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