Genomic predictors of the maximal O2 uptake response to standardized exercise training programs
Claude Bouchard,Mark A. Sarzynski,Treva Rice,William E. Kraus,Timothy S. Church,Yun Ju Sung,D. C. Rao,Tuomo Rankinen +7 more
TLDR
These genomic predictors of the response of Vo(2max) to regular exercise provide new targets for the study of the biology of fitness and its adaptation to regular Exercise.Abstract:
Low cardiorespiratory fitness is a powerful predictor of morbidity and cardiovascular mortality. In 473 sedentary adults, all whites, from 99 families of the Health, Risk Factors, Exercise Training...read more
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Serum Metabolites Related to Cardiorespiratory Fitness, Physical Activity Energy Expenditure, Sedentary Time and Vigorous Activity
Angelika Wientzek,Anna Floegel,Sven Knüppel,Matthaeus Vigl,Dagmar Drogan,Jerzy Adamski,Tobias Pischon,Heiner Boeing +7 more
TL;DR: The results suggest that CRF and PA are associated with serum metabolites, especially CRF with phosphatidylcholines and with the Type 2 diabetes protective factor, and the identified metabolites could be potential mediators of the protective effects of CRf and PA on chronic disease risk.
Journal ArticleDOI
Does blood lactate predict the chronic adaptive response to training: A comparison of traditional and talk test prescription methods.
Nicholas Preobrazenski,Jacob T. Bonafiglia,Matthew W. Nelms,Simo Lu,Lauren Robins,Camille LeBlanc,Brendon J. Gurd +6 more
TL;DR: The preliminary results suggest that future investigations with larger sample sizes should assess the potential superiority of TT over REL, and small to medium between-group effect sizes for changes in peak oxygen consumption, WRpeak, and WROBLA and a higher work rate, heart rate, rating of perceived exertion, and blood lactate during training at NEG support the potential superior of TT.
Journal ArticleDOI
Investigating the reproducibility of maximal oxygen uptake responses to high-intensity interval training.
Michael Del Giudice,Jacob T. Bonafiglia,Hashim Islam,Nicholas Preobrazenski,Alessandra Amato,Brendon J. Gurd +5 more
TL;DR: The results suggest that individual observed VO2max and TTF responses to identical training stimuli are not reproducible.
Journal ArticleDOI
Reproducibility of peak oxygen consumption and the impact of test variability on classification of individual training responses in young recreationally active adults.
Brittany A. Edgett,Jacob T. Bonafiglia,James P. Raleigh,Mario P. Rotundo,Matthew D. Giles,Jonathan P. Whittall,Brendon J. Gurd +6 more
TL;DR: It is recommended that the initial VO2peak test be used as a familiarization visit and not included for analysis, as a potential learning effect was observed in the VO2 peak tests prior to training, as the initial pretraining test was significantly lower than the third.
Journal ArticleDOI
Necessary advances in exercise genomics and likely pitfalls
Yannis P. Pitsiladis,Guan Wang +1 more
TL;DR: A number of methodological approaches within the field of genetic epidemiology have been utilized to unravel the genetic basis of physical performance and the basic family/twin study approach has provided useful and useful results.
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TL;DR: By combining genome-wide association data from 8,130 individuals with type 2 diabetes and 38,987 controls of European descent and following up previously unidentified meta-analysis signals, 12 new T2D association signals are identified with combined P < 5 × 10−8.
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