Gout: An old disease in new perspective – A review
TLDR
Gout is a picturesque presentation of uric acid disturbance as mentioned in this paper, it is the most well understood and described type of arthritis. Diagnosis is based on laboratory and radiological features, the gold standard of diagnosis is identification of characteristic MSU crystals in the synovial fluid using polarized light microscopy.About:
This article is published in Journal of Advanced Research.The article was published on 2017-09-01 and is currently open access. It has received 312 citations till now. The article focuses on the topics: Gout.read more
Citations
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Inflammation in gout: mechanisms and therapeutic targets
Alexander So,Fabio Martinon +1 more
TL;DR: This Review highlights recent advances in the understanding of both positive and negative regulatory pathways, as well as the genetic and environmental factors that modulate the inflammatory response.
Journal ArticleDOI
The role of neutrophil extracellular traps in rheumatic diseases.
TL;DR: The role of neutrophils and NETs in systemic lupus erythematosus, vasculitis, rheumatoid arthritis and gout is discussed in the hope of improving the therapeutic approaches utilized for these diseases.
Journal ArticleDOI
Damage-associated molecular patterns in trauma.
Borna Relja,Walter Land +1 more
TL;DR: This review focuses on the recent literature dealing with the pathophysiological importance of DAMPs after traumatic injury, and so-called model of suppressing/inhibiting inducible DAMPs (SAMPs) will be very briefly introduced.
Journal ArticleDOI
From purines to purinergic signalling: molecular functions and human diseases.
Zhao Huang,Na Xie,Peter Illes,Peter Illes,Francesco Di Virgilio,Henning Ulrich,Henning Ulrich,Alexey Semyanov,Alexey Semyanov,Alexei Verkhratsky,Alexei Verkhratsky,Alexei Verkhratsky,Beáta Sperlágh,Shu-Guang Yu,Canhua Huang,Canhua Huang,Yong Tang +16 more
TL;DR: In this paper, a molecular understanding of molecular mechanisms of purinergic signalling provides new and exciting insights into the treatment of human diseases such as neurodegeneration, rheumatic immune diseases, inflammation, and cancer.
Journal ArticleDOI
Urate-induced immune programming: Consequences for gouty arthritis and hyperuricemia.
TL;DR: It is argued that hyperuricemia is a main culprit in the development of the long‐term systemic inflammation seen in gout and it is enforced that urate is a metabolite that can induce innate immune memory.
References
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Clinical classification of cases of toxic epidermal necrolysis, Stevens-Johnson syndrome, and erythema multiforme
Sylvie Bastuji-Garin,Berthold Rzany,Robert S. Stern,Neil H. Shear,Luigi Naldi,Jean-Claude Roujeau +5 more
TL;DR: This study suggests that an illustrated atlas is a useful tool for standardizing the diagnosis of acute severe bullous disorders that are attributed to drugs or infectious agents.
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2012 American College of Rheumatology guidelines for management of gout. Part 1: Systematic nonpharmacologic and pharmacologic therapeutic approaches to hyperuricemia
Dinesh Khanna,John FitzGerald,Puja P. Khanna,Sangmee Bae,Manjit K. Singh,Tuhina Neogi,Michael H. Pillinger,Joan Merill,Susan J. Lee,Shraddha Prakash,Marian Kaldas,Maneesh Gogia,Fernando Perez-Ruiz,William J. Taylor,Frédéric Lioté,Hyon K. Choi,Jasvinder A. Singh,Nicola Dalbeth,Sanford Kaplan,Vandana Dua Niyyar,Danielle Jones,Steven A. Yarows,Blake J. Roessler,Gail S. Kerr,Charles H. King,Gerald Levy,Daniel E. Furst,N. Lawrence Edwards,Brian F. Mandell,H. Ralph Schumacher,Mark L. Robbins,Neil S. Wenger,Robert Terkeltaub +32 more
TL;DR: DINESH KHanNA, JOHN D. FITZGERALD, PUJA P. KHANNA, SANGMEE BAE, MANJIT K. SINGH, TUHINA NEOGI, MICHAEL H. PILLINGER, JOAN MERILL, SUSAN LEE, SHRADDHA PRAKASH, MARIAN KALDAS, MANEESH GOGIA, FERNANDO PEREZ-RUI
Journal ArticleDOI
EULAR evidence based recommendations for gout. Part II: Management. Report of a task force of the EULAR Standing Committee For International Clinical Studies Including Therapeutics (ESCISIT)
Weiya Zhang,M. Doherty,Thomas Bardin,Eliseo Pascual,V. Barskova,P.G. Conaghan,J Gerster,J Jacobs,Burkhard F. Leeb,Frédéric Lioté,Geraldine M. McCarthy,Patrick Netter,George Nuki,Fernando Perez-Ruiz,A Pignone,J. Pimentao,Leonardo Punzi,Edward Roddy,Till Uhlig,Irena Zimmermann-Górska +19 more
TL;DR: 12 key recommendations for management of gout were developed, using a combination of research based evidence and expert consensus, based on a Delphi consensus approach.
Journal ArticleDOI
Febuxostat compared with allopurinol in patients with hyperuricemia and gout
Michael Becker,H. Ralph Schumacher,Robert L. Wortmann,Patricia A. MacDonald,Denise Eustace,William A. Palo,Janet Streit,Nancy Joseph-Ridge +7 more
TL;DR: Although the incidence of gout flares diminished with continued treatment, the overall incidence during weeks 9 through 52 was similar in all groups andFebuxostat, at a daily dose of 80 mg or 120 mg, was more effective than allopurinol at the commonly used fixed daily doses of 300 mg in lowering serum urate.
Journal ArticleDOI
HLA-B*5801 allele as a genetic marker for severe cutaneous adverse reactions caused by allopurinol
Shuen Lu Hung,Wen-Hung Chung,Wen-Hung Chung,Wen-Hung Chung,Lieh Bang Liou,Chen Chung Chu,Marie Lin,Hsien Ping Huang,Yen Ling Lin,Joung Liang Lan,Li Cheng Yang,Hong Shang Hong,Ming Jing Chen,Ping Chin Lai,Mai Szu Wu,Chia-Yu Chu,Chia-Yu Chu,Kuo Hsien Wang,Chien-Hsiun Chen,Cathy S.J. Fann,Jer-Yuarn Wu,Jer-Yuarn Wu,Yuan-Tsong Chen,Yuan-Tsong Chen +23 more
TL;DR: The results indicated that allopurinol-SCAR is strongly associated with a genetic predisposition in Han Chinese, and in particular, HLA-B*5801 allele is an important genetic risk factor for this life-threatening condition.
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Pascal Richette,Michael Doherty,Eliseo Pascual,V. Barskova,Fabio Becce,Johann Castañeda-Sanabria,M. Coyfish,S Guillo,T.L.Th.A. Jansen,Hein J.E.M. Janssens,Frédéric Lioté,Christian D Mallen,George Nuki,Fernando Perez-Ruiz,J. Pimentao,Leonardo Punzi,T Pywell,Alexander So,Anne-Kathrin Tausche,Till Uhlig,Jakub Zavada,Weiya Zhang,Florence Tubach,Thomas Bardin +23 more