Gut Microbial Metabolite TMAO Enhances Platelet Hyperreactivity and Thrombosis Risk.
Weifei Zhu,Jill C. Gregory,Elin Org,Jennifer A. Buffa,Nilaksh Gupta,Zeneng Wang,Lin Li,Xiaoming Fu,Yuping Wu,Margarete Mehrabian,R. Balfour Sartor,Thomas M. McIntyre,Roy L. Silverstein,W.H. Wilson Tang,Joseph A. DiDonato,J. Mark Brown,Aldons J. Lusis,Stanley L. Hazen +17 more
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TLDR
Gut microbes, through generation of trimethylamine N-oxide (TMAO), directly contribute to platelet hyperreactivity and enhanced thrombosis potential, revealing a previously unrecognized mechanistic link between specific dietary nutrients, gut microbes, platelet function, and thromBosis risk.About:
This article is published in Cell.The article was published on 2016-03-24 and is currently open access. It has received 1219 citations till now. The article focuses on the topics: Platelet activation & Trimethylamine N-oxide.read more
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Microbial Tryptophan Metabolism Tunes Host Immunity, Metabolism, and Extraintestinal Disorders
TL;DR: The importance of tryptophan-derived metabolites in host physiology is highlighted, and the recent findings on the role of tryPTophan catabolites in preserving intestinal homeostasis and fine-tuning immune and metabolic responses are summarized.
Journal ArticleDOI
TMAO and Gut Microbial-Derived Metabolites TML and γBB Are Not Associated with Thrombotic Risk in Patients with Venous Thromboembolism
Marina Canyelles,Melania Plaza,Noemi Rotllan,D. Llobet,Josep Julve,Sergi Mojal,Maribel Diaz-Ricart,José Manuel Soria,Joan Carles Escolà-Gil,Mireia Tondo,Francisco Blanco-Vaca,Juan Souto +11 more
TL;DR: Some correlations were found; however, they were mild or went in the opposite direction of what would be expected if TMAO and its derivatives were related to VTE risk, and no correlation was observed between these gut metabolites and platelet function parameters.
Journal ArticleDOI
The role of trimethylamine N-oxide in progression of cardiovascular diseases
O. V. Trushina,A. A. Bykova,L. K. Malinovskaya,A. Sh. Dumikyan,P. Sh. Chomakhidze,Yu. R. Shaltaeva,Vladimir V. Belyakov,A. V. Golovin,V.S. Pershenkov,Abram Syrkin,V. B. Betelin,Ph. Yu. Kopylov +11 more
Posted ContentDOI
Evidence of a causal and modifiable relationship between kidney function and circulating trimethylamine N-oxide with implications for heart and kidney disorders.
Petros Andrikopoulos,Judith Aron-Wisnewsky,Rima Chakaroun,Antonis Myridakis,Sofia K. Forslund,T R Nielsen,Solia Adriouch,Brian Holmes,Julien Chilloux,Sara Vieira-Silva,Gwen Falony,Joe-Elie Salem,Fabrizio Andreelli,Eric Belda,Julius Kieswich,Kanta Chechi,Francesc Puig-Castellví,M. Chevalier,E. Le Chatelier,Michael Olanipekun,Lesley Hoyles,R. Alves,Gérard Helft,Richard Isnard,Lars Køber,Luis Pedro Coelho,Christine Rouault,Dominique Gauguier,Jens Peter Gøtze,E. Prifti,Jeremy D. Zucker,F. BaÌckhed,Henrik Vestergaard,T. Hansen,JM Oppert,M. BluÌher,J. Nielsen,Jeroen Raes,Peter A. R. Bork,Muhammad M. Yaqoob,Michael Stumvoll,Oluf Pedersen +41 more
TL;DR: In this article , the authors applied explainable machine learning, univariate, multivariate, and mediation analyses of fasting plasma TMAO concentration and a multitude of bioclinical phenotypes in 1,741 adult Europeans of the MetaCardis study.
Journal ArticleDOI
Untargeted Plasma Metabolomics and Gut Microbiome Profiling Provide Novel Insights into the Regulation of Platelet Reactivity in Healthy Individuals
Nadira Vadaq,Nadira Vadaq,Melanie Schirmer,Rahajeng N. Tunjungputri,Rahajeng N. Tunjungputri,Hera Vlamakis,Hera Vlamakis,Cecilia Chiriac,Edwin Ardiansyah,M. Hussein Gasem,Leo A. B. Joosten,Philip G. de Groot,Ramnik J. Xavier,Ramnik J. Xavier,Mihai G. Netea,Mihai G. Netea,André J. A. M. van der Ven,Quirijn de Mast +17 more
TL;DR: In this article, the authors investigated the association of platelet reactivity with results of untargeted plasma metabolomics and gut microbiome profiling using shotgun metagenomic sequencing from stool samples.
References
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An obesity-associated gut microbiome with increased capacity for energy harvest
Peter J. Turnbaugh,Ruth E. Ley,Michael A. Mahowald,Vincent Magrini,Elaine R. Mardis,Jeffrey I. Gordon +5 more
TL;DR: It is demonstrated through metagenomic and biochemical analyses that changes in the relative abundance of the Bacteroidetes and Firmicutes affect the metabolic potential of the mouse gut microbiota and indicates that the obese microbiome has an increased capacity to harvest energy from the diet.
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Fredrik Bäckhed,Hao Ding,Hao Ding,Ting Wang,Lora V. Hooper,Gou Young Koh,Andras Nagy,Clay F. Semenkovich,Jeffrey I. Gordon +8 more
TL;DR: In this article, the authors found that conventionalization of adult germ-free C57BL/6 mice with a normal microbiota harvested from the distal intestine (cecum) of conventionally raised animals produces a 60% increase in body fat content and insulin resistance within 14 days despite reduced food intake.
Journal ArticleDOI
Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease
Zeneng Wang,Elizabeth Klipfell,Brian J. Bennett,Robert A. Koeth,Bruce S. Levison,Brandon DuGar,Ariel E. Feldstein,Earl B. Britt,Xiaoming Fu,Yoon-Mi Chung,Yuping Wu,Phil Schauer,Jonathan D. Smith,Hooman Allayee,W.H. Wilson Tang,Joseph A. DiDonato,Aldons J. Lusis,Stanley L. Hazen +17 more
TL;DR: Discovery of a relationship between gut-flora-dependent metabolism of dietary phosphatidylcholine and CVD pathogenesis provides opportunities for the development of new diagnostic tests and therapeutic approaches for atherosclerotic heart disease.
Journal ArticleDOI
Intestinal microbiota metabolism of L-carnitine, a nutrient in red meat, promotes atherosclerosis
Robert A. Koeth,Zeneng Wang,Bruce S. Levison,Jennifer A. Buffa,Elin Org,Brendan Sheehy,Earl B. Britt,Xiaoming Fu,Yuping Wu,Lin Li,Jonathan D. Smith,Joseph A. DiDonato,Jun Chen,Hongzhe Li,Gary D. Wu,James D. Lewis,Manya Warrier,J. Mark Brown,Ronald M. Krauss,W.H. Wilson Tang,Frederic D. Bushman,Aldons J. Lusis,Stanley L. Hazen +22 more
TL;DR: It is demonstrated that metabolism by intestinal microbiota of dietary l-carnitine, a trimethylamine abundant in red meat, also produces TMAO and accelerates atherosclerosis in mice, and intestinal microbiota may contribute to the well-established link between high levels of red meat consumption and CVD risk.
Journal ArticleDOI
Intestinal Microbial Metabolism of Phosphatidylcholine and Cardiovascular Risk
W.H. Wilson Tang,Zeneng Wang,Bruce S. Levison,Robert A. Koeth,Earl B. Britt,Xiaoming Fu,Yuping Wu,Stanley L. Hazen +7 more
TL;DR: The production of TMAO from dietary phosphatidylcholine is dependent on metabolism by the intestinal microbiota and increased levels are associated with an increased risk of incident major adverse cardiovascular events.
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