Gut Microbial Metabolite TMAO Enhances Platelet Hyperreactivity and Thrombosis Risk.
Weifei Zhu,Jill C. Gregory,Elin Org,Jennifer A. Buffa,Nilaksh Gupta,Zeneng Wang,Lin Li,Xiaoming Fu,Yuping Wu,Margarete Mehrabian,R. Balfour Sartor,Thomas M. McIntyre,Roy L. Silverstein,W.H. Wilson Tang,Joseph A. DiDonato,J. Mark Brown,Aldons J. Lusis,Stanley L. Hazen +17 more
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TLDR
Gut microbes, through generation of trimethylamine N-oxide (TMAO), directly contribute to platelet hyperreactivity and enhanced thrombosis potential, revealing a previously unrecognized mechanistic link between specific dietary nutrients, gut microbes, platelet function, and thromBosis risk.About:
This article is published in Cell.The article was published on 2016-03-24 and is currently open access. It has received 1219 citations till now. The article focuses on the topics: Platelet activation & Trimethylamine N-oxide.read more
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The role of microbial amyloid in neurodegeneration.
TL;DR: The term “mapranosis” is proposed to describe the process of microbiota-associated proteopathy and neuroinflammation, which is a promising area for therapeutic intervention because there are many ways to alter the authors' microbial partners and their products, including amyloid proteins.
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The systemic nature of CKD
Carmine Zoccali,Raymond Vanholder,Ziad A. Massy,Alberto Ortiz,Pantelis Sarafidis,Friedo W. Dekker,Danilo Fliser,Denis Fouque,Gunnar H. Heine,Kitty J Jager,Mehmet Kanbay,Francesca Mallamaci,Gianfranco Parati,Patrick Rossignol,Andrzej Wiecek,Gérard M. London +15 more
TL;DR: A systems biology approach to CKD using omics techniques will hopefully enable in-depth study of the pathophysiology of this systemic disease, and has the potential to unravel critical pathways that can be targeted for CKD prevention and therapy.
Journal ArticleDOI
Recent developments in understanding the role of the gut microbiota in brain health and disease.
TL;DR: Preclinical and clinical evidence suggest that targeting the microbiota through prebiotic, probiotic, or dietary interventions may be an effective “psychobiotic” strategy for treating symptoms in mood, neurodevelopmental disorders, and neurodegenerative diseases.
Journal ArticleDOI
The progress of gut microbiome research related to brain disorders
TL;DR: This review discusses the following parts: Overview of technical approaches used in gut microbiome studies Gut microbiota and metabolites Microbiota-induced blood–brain barrier dysfunction Neuropsychiatric diseases, Pain and migraine, Autism spectrum disorders, Neurodegenerative diseases, and cerebrovascular diseases.
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Relationships between gut microbiota, plasma metabolites, and metabolic syndrome traits in the METSIM cohort
Elin Org,Elin Org,Yuna Blum,Silva Kasela,Margarete Mehrabian,Johanna Kuusisto,Antti J. Kangas,Pasi Soininen,Pasi Soininen,Zeneng Wang,Mika Ala-Korpela,Mika Ala-Korpela,Mika Ala-Korpela,Stanley L. Hazen,Markku Laakso,Aldons J. Lusis +15 more
TL;DR: This study identifies novel relationships between the composition of the gut microbiota and circulating metabolites and provides a resource for future studies to understand host–gut microbiota relationships.
References
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An obesity-associated gut microbiome with increased capacity for energy harvest
Peter J. Turnbaugh,Ruth E. Ley,Michael A. Mahowald,Vincent Magrini,Elaine R. Mardis,Jeffrey I. Gordon +5 more
TL;DR: It is demonstrated through metagenomic and biochemical analyses that changes in the relative abundance of the Bacteroidetes and Firmicutes affect the metabolic potential of the mouse gut microbiota and indicates that the obese microbiome has an increased capacity to harvest energy from the diet.
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The gut microbiota as an environmental factor that regulates fat storage
Fredrik Bäckhed,Hao Ding,Hao Ding,Ting Wang,Lora V. Hooper,Gou Young Koh,Andras Nagy,Clay F. Semenkovich,Jeffrey I. Gordon +8 more
TL;DR: In this article, the authors found that conventionalization of adult germ-free C57BL/6 mice with a normal microbiota harvested from the distal intestine (cecum) of conventionally raised animals produces a 60% increase in body fat content and insulin resistance within 14 days despite reduced food intake.
Journal ArticleDOI
Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease
Zeneng Wang,Elizabeth Klipfell,Brian J. Bennett,Robert A. Koeth,Bruce S. Levison,Brandon DuGar,Ariel E. Feldstein,Earl B. Britt,Xiaoming Fu,Yoon-Mi Chung,Yuping Wu,Phil Schauer,Jonathan D. Smith,Hooman Allayee,W.H. Wilson Tang,Joseph A. DiDonato,Aldons J. Lusis,Stanley L. Hazen +17 more
TL;DR: Discovery of a relationship between gut-flora-dependent metabolism of dietary phosphatidylcholine and CVD pathogenesis provides opportunities for the development of new diagnostic tests and therapeutic approaches for atherosclerotic heart disease.
Journal ArticleDOI
Intestinal microbiota metabolism of L-carnitine, a nutrient in red meat, promotes atherosclerosis
Robert A. Koeth,Zeneng Wang,Bruce S. Levison,Jennifer A. Buffa,Elin Org,Brendan Sheehy,Earl B. Britt,Xiaoming Fu,Yuping Wu,Lin Li,Jonathan D. Smith,Joseph A. DiDonato,Jun Chen,Hongzhe Li,Gary D. Wu,James D. Lewis,Manya Warrier,J. Mark Brown,Ronald M. Krauss,W.H. Wilson Tang,Frederic D. Bushman,Aldons J. Lusis,Stanley L. Hazen +22 more
TL;DR: It is demonstrated that metabolism by intestinal microbiota of dietary l-carnitine, a trimethylamine abundant in red meat, also produces TMAO and accelerates atherosclerosis in mice, and intestinal microbiota may contribute to the well-established link between high levels of red meat consumption and CVD risk.
Journal ArticleDOI
Intestinal Microbial Metabolism of Phosphatidylcholine and Cardiovascular Risk
W.H. Wilson Tang,Zeneng Wang,Bruce S. Levison,Robert A. Koeth,Earl B. Britt,Xiaoming Fu,Yuping Wu,Stanley L. Hazen +7 more
TL;DR: The production of TMAO from dietary phosphatidylcholine is dependent on metabolism by the intestinal microbiota and increased levels are associated with an increased risk of incident major adverse cardiovascular events.
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