Gut Microbial Metabolite TMAO Enhances Platelet Hyperreactivity and Thrombosis Risk.
Weifei Zhu,Jill C. Gregory,Elin Org,Jennifer A. Buffa,Nilaksh Gupta,Zeneng Wang,Lin Li,Xiaoming Fu,Yuping Wu,Margarete Mehrabian,R. Balfour Sartor,Thomas M. McIntyre,Roy L. Silverstein,W.H. Wilson Tang,Joseph A. DiDonato,J. Mark Brown,Aldons J. Lusis,Stanley L. Hazen +17 more
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TLDR
Gut microbes, through generation of trimethylamine N-oxide (TMAO), directly contribute to platelet hyperreactivity and enhanced thrombosis potential, revealing a previously unrecognized mechanistic link between specific dietary nutrients, gut microbes, platelet function, and thromBosis risk.About:
This article is published in Cell.The article was published on 2016-03-24 and is currently open access. It has received 1219 citations till now. The article focuses on the topics: Platelet activation & Trimethylamine N-oxide.read more
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Emerging targetome and signalome landscape of gut microbial metabolites.
TL;DR: In this article , the authors present an updated understanding of how microbial metabolite interaction with host targets finely orchestrates and integrates multiple signals to pathophysiological phenotypes, contributing new insights into organ crosstalk and holistic homeostasis maintenance in biological systems.
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Targeting the human microbiome and its metabolite TMAO in cardiovascular prevention and therapy.
Lisa Dannenberg,Dorothee Zikeli,Marcel Benkhoff,Samantha Ahlbrecht,Malte Kelm,Bodo Levkau,Amin Polzin +6 more
TL;DR: The effects of changes in the gut microbiota as well as the important metabolite Trimethylamine-N-oxide (TMAO) are focused on.
Journal ArticleDOI
Is increased plasma TMAO a compensatory response to hydrostatic and osmotic stress in cardiovascular diseases
Marcin Ufnal,Artur Nowiński +1 more
TL;DR: It is hypothesized that increased plasma TMAO serves as a compensatory response mechanism which protects cells from hydrostatic and osmotic stresses and is present in humans consuming seafood-rich diet which is thought to be health-beneficial.
Journal ArticleDOI
Gut Microbiota Alteration After Long-Term Consumption of Probiotics in the Elderly
TL;DR: It is demonstrated that the long-time intake of probiotics caused significant changes in the gut microbiota structure, including an increase in the composition of beneficial microorganisms, which might contribute to the maintenance of host health and homeostasis of microenvironment.
Journal ArticleDOI
Intestinal microbiota dysbiosis play a role in pathogenesis of patients with primary immune thrombocytopenia.
Chanjuan Liu,Luya Cheng,Lili Ji,Feng Li,Yanxia Zhan,Boting Wu,Yang Ke,Pu Chen,Fanli Hua,Ling Yuan,Zhihui Min,Lihua Sun,Hao Chen,Yunfeng Cheng +13 more
TL;DR: It is suggested that the distinct microbiota dysbiosis in ITP characterized by alterations in biodiversity and composition, which could provide insights for diet therapy and fecal microbiota transplantation treatment to cure ITP.
References
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An obesity-associated gut microbiome with increased capacity for energy harvest
Peter J. Turnbaugh,Ruth E. Ley,Michael A. Mahowald,Vincent Magrini,Elaine R. Mardis,Jeffrey I. Gordon +5 more
TL;DR: It is demonstrated through metagenomic and biochemical analyses that changes in the relative abundance of the Bacteroidetes and Firmicutes affect the metabolic potential of the mouse gut microbiota and indicates that the obese microbiome has an increased capacity to harvest energy from the diet.
Journal ArticleDOI
The gut microbiota as an environmental factor that regulates fat storage
Fredrik Bäckhed,Hao Ding,Hao Ding,Ting Wang,Lora V. Hooper,Gou Young Koh,Andras Nagy,Clay F. Semenkovich,Jeffrey I. Gordon +8 more
TL;DR: In this article, the authors found that conventionalization of adult germ-free C57BL/6 mice with a normal microbiota harvested from the distal intestine (cecum) of conventionally raised animals produces a 60% increase in body fat content and insulin resistance within 14 days despite reduced food intake.
Journal ArticleDOI
Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease
Zeneng Wang,Elizabeth Klipfell,Brian J. Bennett,Robert A. Koeth,Bruce S. Levison,Brandon DuGar,Ariel E. Feldstein,Earl B. Britt,Xiaoming Fu,Yoon-Mi Chung,Yuping Wu,Phil Schauer,Jonathan D. Smith,Hooman Allayee,W.H. Wilson Tang,Joseph A. DiDonato,Aldons J. Lusis,Stanley L. Hazen +17 more
TL;DR: Discovery of a relationship between gut-flora-dependent metabolism of dietary phosphatidylcholine and CVD pathogenesis provides opportunities for the development of new diagnostic tests and therapeutic approaches for atherosclerotic heart disease.
Journal ArticleDOI
Intestinal microbiota metabolism of L-carnitine, a nutrient in red meat, promotes atherosclerosis
Robert A. Koeth,Zeneng Wang,Bruce S. Levison,Jennifer A. Buffa,Elin Org,Brendan Sheehy,Earl B. Britt,Xiaoming Fu,Yuping Wu,Lin Li,Jonathan D. Smith,Joseph A. DiDonato,Jun Chen,Hongzhe Li,Gary D. Wu,James D. Lewis,Manya Warrier,J. Mark Brown,Ronald M. Krauss,W.H. Wilson Tang,Frederic D. Bushman,Aldons J. Lusis,Stanley L. Hazen +22 more
TL;DR: It is demonstrated that metabolism by intestinal microbiota of dietary l-carnitine, a trimethylamine abundant in red meat, also produces TMAO and accelerates atherosclerosis in mice, and intestinal microbiota may contribute to the well-established link between high levels of red meat consumption and CVD risk.
Journal ArticleDOI
Intestinal Microbial Metabolism of Phosphatidylcholine and Cardiovascular Risk
W.H. Wilson Tang,Zeneng Wang,Bruce S. Levison,Robert A. Koeth,Earl B. Britt,Xiaoming Fu,Yuping Wu,Stanley L. Hazen +7 more
TL;DR: The production of TMAO from dietary phosphatidylcholine is dependent on metabolism by the intestinal microbiota and increased levels are associated with an increased risk of incident major adverse cardiovascular events.
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