Gut Microbial Metabolite TMAO Enhances Platelet Hyperreactivity and Thrombosis Risk.
Weifei Zhu,Jill C. Gregory,Elin Org,Jennifer A. Buffa,Nilaksh Gupta,Zeneng Wang,Lin Li,Xiaoming Fu,Yuping Wu,Margarete Mehrabian,R. Balfour Sartor,Thomas M. McIntyre,Roy L. Silverstein,W.H. Wilson Tang,Joseph A. DiDonato,J. Mark Brown,Aldons J. Lusis,Stanley L. Hazen +17 more
Reads0
Chats0
TLDR
Gut microbes, through generation of trimethylamine N-oxide (TMAO), directly contribute to platelet hyperreactivity and enhanced thrombosis potential, revealing a previously unrecognized mechanistic link between specific dietary nutrients, gut microbes, platelet function, and thromBosis risk.About:
This article is published in Cell.The article was published on 2016-03-24 and is currently open access. It has received 1219 citations till now. The article focuses on the topics: Platelet activation & Trimethylamine N-oxide.read more
Citations
More filters
Journal ArticleDOI
Selenium in Human Health and Gut Microflora: Bioavailability of Selenocompounds and Relationship With Diseases.
Rannapaula Lawrynhuk Urbano Ferreira,Karine Cavalcanti Maurício Sena-Evangelista,Eduardo Pereira de Azevedo,Francisco Irochima Pinheiro,Ricardo Ney Cobucci,Lucia Fatima Campos Pedrosa +5 more
TL;DR: A review of the current knowledge of selenium in the dietary intake, its bioavailability, metabolism, functions, biomarkers, supplementation and toxicity can be found in this article.
Journal ArticleDOI
Are noncommunicable diseases communicable
TL;DR: It is proposed that some NCDs could have a microbial component and, if so, might be communicable via the microbiota.
Journal ArticleDOI
Gut Microbiota and Coronary Artery Disease.
TL;DR: It is hoped the reports listed in this review article might lead to the development of a novel therapy to prevent CAD via modulating gut microbiota or their metabolites, and the biological significance of gut microbiota and the causal relationships are still controversial.
Journal ArticleDOI
Role and Effective Therapeutic Target of Gut Microbiota in Heart Failure
Qiujin Jia,Hao Li,Huan Zhou,Xiaonan Zhang,Ao Zhang,Yingyu Xie,Yanyang Li,Shichao Lv,Junping Zhang +8 more
TL;DR: It is clarified that intestinal barrier damage and bacterial translocation induced inflammation and immune response aggravated heart failure, and altered intestinal microflora affected various metabolic pathways including trimethylamine/TMAO, SCFA, and Bile acid pathway leads to heart failure.
Journal ArticleDOI
Inhibition of microbiota-dependent TMAO production attenuates chronic kidney disease in mice.
Wenchao Zhang,Wenchao Zhang,Wenchao Zhang,Aika Miikeda,Jonathan E. Zuckerman,Xun Jia,Sarada Charugundla,Zhiqiang Zhou,Karolina Elżbieta Kaczor-Urbanowicz,Clara E. Magyar,Fangfei Guo,Zeneng Wang,Matteo Pellegrini,Stanley L. Hazen,Stanley L. Hazen,Susanne B. Nicholas,Aldons J. Lusis,Diana M. Shih +17 more
TL;DR: In this article, the interaction between TMAO, kidney disease, and cardiovascular disease in mouse models was examined, and it was shown that TMA reduction may be a novel strategy in treating CKD and its cardiovascular disease complications.
References
More filters
Journal ArticleDOI
An obesity-associated gut microbiome with increased capacity for energy harvest
Peter J. Turnbaugh,Ruth E. Ley,Michael A. Mahowald,Vincent Magrini,Elaine R. Mardis,Jeffrey I. Gordon +5 more
TL;DR: It is demonstrated through metagenomic and biochemical analyses that changes in the relative abundance of the Bacteroidetes and Firmicutes affect the metabolic potential of the mouse gut microbiota and indicates that the obese microbiome has an increased capacity to harvest energy from the diet.
Journal ArticleDOI
The gut microbiota as an environmental factor that regulates fat storage
Fredrik Bäckhed,Hao Ding,Hao Ding,Ting Wang,Lora V. Hooper,Gou Young Koh,Andras Nagy,Clay F. Semenkovich,Jeffrey I. Gordon +8 more
TL;DR: In this article, the authors found that conventionalization of adult germ-free C57BL/6 mice with a normal microbiota harvested from the distal intestine (cecum) of conventionally raised animals produces a 60% increase in body fat content and insulin resistance within 14 days despite reduced food intake.
Journal ArticleDOI
Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease
Zeneng Wang,Elizabeth Klipfell,Brian J. Bennett,Robert A. Koeth,Bruce S. Levison,Brandon DuGar,Ariel E. Feldstein,Earl B. Britt,Xiaoming Fu,Yoon-Mi Chung,Yuping Wu,Phil Schauer,Jonathan D. Smith,Hooman Allayee,W.H. Wilson Tang,Joseph A. DiDonato,Aldons J. Lusis,Stanley L. Hazen +17 more
TL;DR: Discovery of a relationship between gut-flora-dependent metabolism of dietary phosphatidylcholine and CVD pathogenesis provides opportunities for the development of new diagnostic tests and therapeutic approaches for atherosclerotic heart disease.
Journal ArticleDOI
Intestinal microbiota metabolism of L-carnitine, a nutrient in red meat, promotes atherosclerosis
Robert A. Koeth,Zeneng Wang,Bruce S. Levison,Jennifer A. Buffa,Elin Org,Brendan Sheehy,Earl B. Britt,Xiaoming Fu,Yuping Wu,Lin Li,Jonathan D. Smith,Joseph A. DiDonato,Jun Chen,Hongzhe Li,Gary D. Wu,James D. Lewis,Manya Warrier,J. Mark Brown,Ronald M. Krauss,W.H. Wilson Tang,Frederic D. Bushman,Aldons J. Lusis,Stanley L. Hazen +22 more
TL;DR: It is demonstrated that metabolism by intestinal microbiota of dietary l-carnitine, a trimethylamine abundant in red meat, also produces TMAO and accelerates atherosclerosis in mice, and intestinal microbiota may contribute to the well-established link between high levels of red meat consumption and CVD risk.
Journal ArticleDOI
Intestinal Microbial Metabolism of Phosphatidylcholine and Cardiovascular Risk
W.H. Wilson Tang,Zeneng Wang,Bruce S. Levison,Robert A. Koeth,Earl B. Britt,Xiaoming Fu,Yuping Wu,Stanley L. Hazen +7 more
TL;DR: The production of TMAO from dietary phosphatidylcholine is dependent on metabolism by the intestinal microbiota and increased levels are associated with an increased risk of incident major adverse cardiovascular events.
Related Papers (5)
Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease
Intestinal microbiota metabolism of L-carnitine, a nutrient in red meat, promotes atherosclerosis
Robert A. Koeth,Zeneng Wang,Bruce S. Levison,Jennifer A. Buffa,Elin Org,Brendan Sheehy,Earl B. Britt,Xiaoming Fu,Yuping Wu,Lin Li,Jonathan D. Smith,Joseph A. DiDonato,Jun Chen,Hongzhe Li,Gary D. Wu,James D. Lewis,Manya Warrier,J. Mark Brown,Ronald M. Krauss,W.H. Wilson Tang,Frederic D. Bushman,Aldons J. Lusis,Stanley L. Hazen +22 more