Gut Microbial Metabolite TMAO Enhances Platelet Hyperreactivity and Thrombosis Risk.
Weifei Zhu,Jill C. Gregory,Elin Org,Jennifer A. Buffa,Nilaksh Gupta,Zeneng Wang,Lin Li,Xiaoming Fu,Yuping Wu,Margarete Mehrabian,R. Balfour Sartor,Thomas M. McIntyre,Roy L. Silverstein,W.H. Wilson Tang,Joseph A. DiDonato,J. Mark Brown,Aldons J. Lusis,Stanley L. Hazen +17 more
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TLDR
Gut microbes, through generation of trimethylamine N-oxide (TMAO), directly contribute to platelet hyperreactivity and enhanced thrombosis potential, revealing a previously unrecognized mechanistic link between specific dietary nutrients, gut microbes, platelet function, and thromBosis risk.About:
This article is published in Cell.The article was published on 2016-03-24 and is currently open access. It has received 1219 citations till now. The article focuses on the topics: Platelet activation & Trimethylamine N-oxide.read more
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New technologies for developing phage-based tools to manipulate the human microbiome.
Mohammadali Khan Mirzaei,Li Deng +1 more
TL;DR: In this paper, the authors discuss recent advances in cultivation-independent technologies and argue their relevance to different key steps, that is, identifying the modulation targets and developing phage-based tools to precisely modulate gut bacteria and restore a sustainable microbiome in humans.
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Prevention of Vascular Inflammation by Pterostilbene via Trimethylamine-N-Oxide Reduction and Mechanism of Microbiota Regulation.
Yen Chun Koh,Shiming Li,Pei Yu Chen,Jia Ching Wu,Nagabhushanam Kalyanam,Chi-Tang Ho,Min-Hsiung Pan +6 more
TL;DR: Data suggest that amelioration of carnitine-induced vascular inflammation after consumption of pterostilbene is partially mediated via modulation of gut microbiota composition and hepatic enzyme FMO3 gene expression.
Journal ArticleDOI
Gut Microbiota and Stroke
TL;DR: This review presents the current understanding about the interaction between commensal gut microbiome and brain in determining the course of stroke and examines the role of gut microbiota dysbiosis and various complications and outcomes.
Journal ArticleDOI
Gut microbiota-associated trimethylamine N-oxide and increased cardiometabolic risk in adults: a systematic review and dose-response meta-analysis.
TL;DR: Circulating TMAO is positively associated with an increased risk of hypertension and other cardiometabolic disorders in adults and is associated with reduced high-density lipoprotein cholesterol in apparently healthy individuals and reducedHigh- density lipop Protein cholesterol and increased total cholesterol in patients with cardiovascular disease.
Journal ArticleDOI
Platelet Abnormalities in CKD and Their Implications for Antiplatelet Therapy
TL;DR: In this article , the authors summarized the knowledge on CKD-induced aberrations in hemostasis, with a special focus on platelet abnormalities, and discussed how prominent alterations in vascular integrity, coagulation, and red blood cell count in CKD may contribute to altered platelet function resulting in either platelet hyper- or hyporeactivity.
References
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An obesity-associated gut microbiome with increased capacity for energy harvest
Peter J. Turnbaugh,Ruth E. Ley,Michael A. Mahowald,Vincent Magrini,Elaine R. Mardis,Jeffrey I. Gordon +5 more
TL;DR: It is demonstrated through metagenomic and biochemical analyses that changes in the relative abundance of the Bacteroidetes and Firmicutes affect the metabolic potential of the mouse gut microbiota and indicates that the obese microbiome has an increased capacity to harvest energy from the diet.
Journal ArticleDOI
The gut microbiota as an environmental factor that regulates fat storage
Fredrik Bäckhed,Hao Ding,Hao Ding,Ting Wang,Lora V. Hooper,Gou Young Koh,Andras Nagy,Clay F. Semenkovich,Jeffrey I. Gordon +8 more
TL;DR: In this article, the authors found that conventionalization of adult germ-free C57BL/6 mice with a normal microbiota harvested from the distal intestine (cecum) of conventionally raised animals produces a 60% increase in body fat content and insulin resistance within 14 days despite reduced food intake.
Journal ArticleDOI
Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease
Zeneng Wang,Elizabeth Klipfell,Brian J. Bennett,Robert A. Koeth,Bruce S. Levison,Brandon DuGar,Ariel E. Feldstein,Earl B. Britt,Xiaoming Fu,Yoon-Mi Chung,Yuping Wu,Phil Schauer,Jonathan D. Smith,Hooman Allayee,W.H. Wilson Tang,Joseph A. DiDonato,Aldons J. Lusis,Stanley L. Hazen +17 more
TL;DR: Discovery of a relationship between gut-flora-dependent metabolism of dietary phosphatidylcholine and CVD pathogenesis provides opportunities for the development of new diagnostic tests and therapeutic approaches for atherosclerotic heart disease.
Journal ArticleDOI
Intestinal microbiota metabolism of L-carnitine, a nutrient in red meat, promotes atherosclerosis
Robert A. Koeth,Zeneng Wang,Bruce S. Levison,Jennifer A. Buffa,Elin Org,Brendan Sheehy,Earl B. Britt,Xiaoming Fu,Yuping Wu,Lin Li,Jonathan D. Smith,Joseph A. DiDonato,Jun Chen,Hongzhe Li,Gary D. Wu,James D. Lewis,Manya Warrier,J. Mark Brown,Ronald M. Krauss,W.H. Wilson Tang,Frederic D. Bushman,Aldons J. Lusis,Stanley L. Hazen +22 more
TL;DR: It is demonstrated that metabolism by intestinal microbiota of dietary l-carnitine, a trimethylamine abundant in red meat, also produces TMAO and accelerates atherosclerosis in mice, and intestinal microbiota may contribute to the well-established link between high levels of red meat consumption and CVD risk.
Journal ArticleDOI
Intestinal Microbial Metabolism of Phosphatidylcholine and Cardiovascular Risk
W.H. Wilson Tang,Zeneng Wang,Bruce S. Levison,Robert A. Koeth,Earl B. Britt,Xiaoming Fu,Yuping Wu,Stanley L. Hazen +7 more
TL;DR: The production of TMAO from dietary phosphatidylcholine is dependent on metabolism by the intestinal microbiota and increased levels are associated with an increased risk of incident major adverse cardiovascular events.
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