Hepatic myofibroblasts promote the progression of human cholangiocarcinoma through activation of epidermal growth factor receptor
Audrey Clapéron,Martine Mergey,Lynda Aoudjehane,Thanh Huong Nguyen Ho-Bouldoires,Dominique Wendum,Aurélie Prignon,Fatiha Merabtene,Delphine Firrincieli,Christèle Desbois-Mouthon,Olivier Scatton,Filomena Conti,Chantal Housset,Laura Fouassier +12 more
TLDR
A reciprocal cross‐talk between CCA cells and myofibroblasts through the HB‐EGF/EGFR axis contributes to CCA progression.About:
This article is published in Hepatology.The article was published on 2013-12-01 and is currently open access. It has received 76 citations till now. The article focuses on the topics: Epidermal growth factor & Gefitinib.read more
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Cholangiocarcinoma 2020: the next horizon in mechanisms and management
Jesus M. Banales,Jesus M. Banales,Jesus M. Banales,Jose J.G. Marin,Jose J.G. Marin,Angela Lamarca,Angela Lamarca,Pedro M. Rodrigues,Shahid A. Khan,Lewis R. Roberts,Vincenzo Cardinale,Guido Carpino,Jesper B. Andersen,Chiara Braconi,Diego F. Calvisi,Maria J. Perugorria,Maria J. Perugorria,Luca Fabris,Luca Fabris,Luke Boulter,Rocio I.R. Macias,Rocio I.R. Macias,Eugenio Gaudio,Domenico Alvaro,Sergio A. Gradilone,Mario Strazzabosco,Mario Strazzabosco,Marco Marzioni,Cédric Coulouarn,Laura Fouassier,Chiara Raggi,Pietro Invernizzi,Joachim C. Mertens,Anja Moncsek,Sumera Rizvi,Julie K. Heimbach,Bas Groot Koerkamp,Jordi Bruix,Jordi Bruix,Alejandro Forner,Alejandro Forner,John Bridgewater,Juan W. Valle,Juan W. Valle,Gregory J. Gores +44 more
TL;DR: This expert Consensus Statement, endorsed by the ENS-CCA, summarizes the latest advances in CCA, including classification, genetics and treatment, and provides recommendations for CCA management and priorities across basic, translational and clinical research.
Journal ArticleDOI
Expert consensus document: Cholangiocarcinoma: current knowledge and future perspectives consensus statement from the European Network for the Study of Cholangiocarcinoma (ENS-CCA)
Jesus M. Banales,Vincenzo Cardinale,Guido Carpino,Marco Marzioni,Jesper B. Andersen,Pietro Invernizzi,Guro Elisabeth Lind,Trine Folseraas,Stuart J. Forbes,Laura Fouassier,Andreas Geier,Diego F. Calvisi,Joachim C. Mertens,Michael Trauner,Antonio Benedetti,Luca Maroni,Javier Vaquero,Rocio I.R. Macias,Chiara Raggi,Maria J. Perugorria,Eugenio Gaudio,Kirsten Muri Boberg,Jose J.G. Marin,Domenico Alvaro +23 more
TL;DR: This Consensus Statement aims to provide valuable information on classifications, pathological features, risk factors, cells of origin, genetic and epigenetic modifications and current therapies available for this cancer.
Journal ArticleDOI
The Role of Cancer-Associated Fibroblasts and Fibrosis in Liver Cancer
TL;DR: The functional contributions of myofibroblasts, CAFs, and fibrosis to the development of HCC and CCA in the hepatic PME and TME are discussed, focusing on my ofibroblast- and extracellular matrix-associated growth factors, fibrosis-associated immunosuppressive pathways, as well as mechanosensitive signaling cascades that are activated by increased tissue stiffness.
Journal ArticleDOI
Cancer-associated fibroblasts in gastrointestinal cancer
Hiroki Kobayashi,Atsushi Enomoto,Susan L. Woods,Alastair D. Burt,Masahide Takahashi,Daniel L. Worthley +5 more
TL;DR: An improved understanding of CAF biology could lead to the development of novel stroma-based diagnostics, prognostics and therapeutics, and the clinical implications of CAFs as biomarkers and potential targets for prevention and treatment of patients with gastrointestinal cancer are discussed.
Journal ArticleDOI
Cellular Mechanisms of Tissue Fibrosis. 5. Novel insights into liver fibrosis
Ariane Mallat,Sophie Lotersztajn +1 more
TL;DR: This review will highlight recent advances regarding the mechanisms that regulate liver fibrogenesis and fibrosis regression, with special focus on novel signaling pathways and the role of inflammatory cells.
References
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Global cancer statistics
TL;DR: A substantial proportion of the worldwide burden of cancer could be prevented through the application of existing cancer control knowledge and by implementing programs for tobacco control, vaccination, and early detection and treatment, as well as public health campaigns promoting physical activity and a healthier dietary intake.
Journal ArticleDOI
Recent developments in myofibroblast biology: paradigms for connective tissue remodeling.
Boris Hinz,Sem H. Phan,Victor J. Thannickal,Marco Prunotto,Alexis Desmoulière,John Varga,Olivier De Wever,Marc Mareel,Giulio Gabbiani +8 more
TL;DR: The origin and the specific features of the myofibroblast in diverse fibrotic lesions, such as systemic sclerosis; kidney, liver, and lung fibrosis; and the stromal reaction to certain epithelial tumors are reviewed.
Journal ArticleDOI
Stromal myofibroblasts are drivers of invasive cancer growth.
TL;DR: Fibrosis is a major side effect of radiotherapy, and the question how the main methods of cancer management, including chemotherapy, hormonotherapy and surgery affect myofibroblasts and by inference the surrogate endpoints invasion and metastasis is addressed.
Journal ArticleDOI
Transforming growth factor-beta and fibrosis.
Franck Verrecchia,Alain Mauviel +1 more
TL;DR: The role of Smad proteins in the transcriptional regulation of type I collagen gene expression and in the development of fibrosis, demonstrated both in vitro and in animal models with a targeted deletion of Smads3, is of critical importance because it may lead to novel therapeutic strategies against these diseases.
Journal ArticleDOI
Genomic and Genetic Characterization of Cholangiocarcinoma Identifies Therapeutic Targets for Tyrosine Kinase Inhibitors
Jesper B. Andersen,Bart Spee,Boris Blechacz,Itzhak Avital,Mina Komuta,Andrew Barbour,Elizabeth A. Conner,Matthew C. Gillen,Tania Roskams,Lewis R. Roberts,Valentina M. Factor,Snorri S. Thorgeirsson +11 more
TL;DR: Insight into the pathogenesis of cholangiocarcinoma is provided and previously unrecognized subclasses of patients, based on KRAS mutations and increased levels of EGFR and HER2 signaling, who might benefit from dual-target tyrosine kinase inhibitors are identified.
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Platelet-derived growth factor-D and Rho GTPases regulate recruitment of cancer-associated fibroblasts in cholangiocarcinoma
Expert consensus document: Cholangiocarcinoma: current knowledge and future perspectives consensus statement from the European Network for the Study of Cholangiocarcinoma (ENS-CCA)
Jesus M. Banales,Vincenzo Cardinale,Guido Carpino,Marco Marzioni,Jesper B. Andersen,Pietro Invernizzi,Guro Elisabeth Lind,Trine Folseraas,Stuart J. Forbes,Laura Fouassier,Andreas Geier,Diego F. Calvisi,Joachim C. Mertens,Michael Trauner,Antonio Benedetti,Luca Maroni,Javier Vaquero,Rocio I.R. Macias,Chiara Raggi,Maria J. Perugorria,Eugenio Gaudio,Kirsten Muri Boberg,Jose J.G. Marin,Domenico Alvaro +23 more