HIV-1: fifteen proteins and an RNA.
Alan D. Frankel,John A. T. Young +1 more
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TLDR
A review of recent biochemical and structural studies that help clarify the mechanisms of viral assembly, infection, and replication of human immunodeficiency virus type 1.Abstract:
Human immunodeficiency virus type 1 is a complex retrovirus encoding 15 distinct proteins. Substantial progress has been made toward understanding the function of each protein, and three-dimensional structures of many components, including portions of the RNA genome, have been determined. This review describes the function of each component in the context of the viral life cycle: the Gag and Env structural proteins MA (matrix), CA (capsid), NC (nucleocapsid), p6, SU (surface), and TM (transmembrane); the Pol enzymes PR (protease), RT (reverse transcriptase), and IN (integrase); the gene regulatory proteins Tat and Rev; and the accessory proteins Nef, Vif, Vpr, and Vpu. The review highlights recent biochemical and structural studies that help clarify the mechanisms of viral assembly, infection, and replication.read more
Citations
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A unified classification system for eukaryotic transposable elements
Thomas Wicker,François Sabot,Aurélie Hua-Van,Jeffrey L. Bennetzen,Pierre Capy,Boulos Chalhoub,Andrew J. Flavell,Philippe Leroy,Michele Morgante,Olivier Panaud,Etienne Paux,Phillip SanMiguel,Alan H. Schulman +12 more
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Matrix Proteoglycans: From Molecular Design to Cellular Function
TL;DR: The proteoglycan superfamily now contains more than 30 full-time molecules that fulfill a variety of biological functions and additional roles, derived from studies of mutant animals, indicate that certain proteoglycans are essential to life whereas others might be redundant.
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Identification of Host Proteins Required for HIV Infection Through a Functional Genomic Screen
Abraham L. Brass,Derek M. Dykxhoorn,Yair Benita,Nan Yan,Alan Engelman,Ramnik J. Xavier,Judy Lieberman,Stephen J. Elledge +7 more
TL;DR: This article performed a large-scale small interfering RNA screen to identify host factors required by HIV-1 and identified more than 250 HIV-dependency factors (HDFs), which participate in a broad array of cellular functions and implicate new pathways in the viral life cycle.
Identification of host proteins required for HIV infection through a functional genomic screen
TL;DR: A large-scale small interfering RNA screen was performed to identify host factors required by HIV-1 and more than 250 HIV-dependency factors (HDFs) were identified, suggesting that viruses evolve in host cells that optimally perform the functions required for their life cycle.
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Architecture and secondary structure of an entire HIV-1 RNA genome
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TL;DR: The structure of an entire HIV-1 genome at single nucleotide resolution is reported using SHAPE, a high-throughput RNA analysis technology and indicates that extensive RNA structure constitutes an important component of the genetic code.
References
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Journal ArticleDOI
MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures
TL;DR: The MOLSCRIPT program as discussed by the authors produces plots of protein structures using several different kinds of representations, including simple wire models, ball-and-stick models, CPK models and text labels.
Journal ArticleDOI
The β-Chemokine Receptors CCR3 and CCR5 Facilitate Infection by Primary HIV-1 Isolates
Hyeryun Choe,Michael Farzan,Ying Sun,Nancy Sullivan,Barrett J. Rollins,Paul D. Ponath,Lijun Wu,Charles R. Mackay,Gregory J. LaRosa,Walter Newman,Norma P. Gerard,Craig Gerard,Joseph Sodroski +12 more
TL;DR: The ability of various members of the chemokine receptor family to support the early stages of HIV-1 infection helps to explain viral tropism and beta-chemokine inhibition of primary HIV- 1 isolates.
PatentDOI
Core structure of GP41 from the HIV envelope glycoprotein
TL;DR: The crystal structure of this complex, composed of the peptides N36 and C34, is a six-helical bundle that shows striking similarity to the low-pH-induced conformation of influenza hemagglutinin and likely represents the core of fusion-active gp41.
Journal ArticleDOI
The lymphocyte chemoattractant SDF-1 is a ligand for LESTR/fusin and blocks HIV-1 entry.
Conrad C. Bleul,Michael Farzan,Hyeryun Choe,Cristina Parolin,Cristina Parolin,Ian Clark-Lewis,Joseph Sodroski,Timothy A. Springer +7 more
TL;DR: Testing of potential receptors demonstrated that SDF-1 signalled through, and hence 'adopted', the orphan receptor LESTR, which is therefore designated CXC-chemokine receptor-4 (CXCR-4).
Journal ArticleDOI
Crystal structure at 3.5 A resolution of HIV-1 reverse transcriptase complexed with an inhibitor.
TL;DR: A 3.5 angstrom resolution electron density map of the HIV-1 reverse transcriptase heterodimer complexed with nevirapine, a drug with potential for treatment of AIDS, reveals an asymmetric dimer.