Holding the inflammatory system in check: NLRs keep it cool.
Sushmita Jha,Jenny P.-Y. Ting +1 more
TLDR
This report aims to review the literature regarding several members of the nucleotide-binding domain, leucine-rich repeat-containing receptor (NLR) family of pattern recognition sensors/receptors that serve as checkpoints for inflammation.Abstract:
Inflammation is a double-edged sword. While short-lived, acute inflammation is essential for the repair and resolution of infection and damage, uncontrolled and unresolved chronic inflammation is central to several diseases, including cancer, autoimmune diseases, allergy, metabolic disease, and cardiovascular disease. This report aims to review the literature regarding several members of the nucleotide-binding domain, leucine-rich repeat-containing receptor (NLR) family of pattern recognition sensors/receptors that serve as checkpoints for inflammation. Understanding the negative regulation of inflammation is highly relevant to the development of therapeutics for inflammatory as well as infectious diseases.read more
Citations
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NLR-Dependent Regulation of Inflammation in Multiple Sclerosis
Marjan Gharagozloo,Katsiaryna V. Gris,Tara M. Mahvelati,Abdelaziz Amrani,John R. Lukens,Denis Gris +5 more
TL;DR: A summary of the role of NLRs in the pathogenesis of MS is provided and how anti-inflammatory NLRs regulate the immune response within the CNS is summarized.
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Inflammatory pathway genes associated with inter-individual variability in the trajectories of morning and evening fatigue in patients receiving chemotherapy.
Fay Wright,Marilyn J. Hammer,Steven M. Paul,Bradley E. Aouizerat,Kord M. Kober,Yvette P. Conley,Bruce A. Cooper,Laura B. Dunn,Jon D. Levine,Gail D'Eramo Melkus,Christine Miaskowski +10 more
TL;DR: Findings add to the growing body of evidence that suggests that morning and evening fatigue are distinct symptoms.
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Modeling-Enabled Characterization of Novel NLRX1 Ligands
Pinyi Lu,Raquel Hontecillas,Vida Abedi,Shiv D. Kale,Andrew Leber,Chase Heltzel,Mark Langowski,Victoria Godfrey,Casandra Philipson,Nuria Tubau-Juni,Adria Carbo,Stephen E. Girardin,Aykut Üren,Josep Bassaganya-Riera +13 more
TL;DR: The findings showed that the regulatory function of PUA on colitis is NLRX1 dependent and identified novel small molecules that bind to NLRx1 and exert anti-inflammatory actions.
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Host inflammatory responses to intracellular invaders: Review study
TL;DR: Inflammasome components assemble and oligomerizes leading to the auto cleavage of the pro-caspase-1 to its active form and controls the establishment of the pathogen by mounting inflammatory response and activation of the pyroptotic cell death.
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S1PR1 expression correlates with inflammatory responses to Newcastle disease virus infection
Yaling Li,Peng Xie,Minhua Sun,Bin Xiang,Yinfeng Kang,Pei Gao,Wenxian Zhu,Zhangyong Ning,Tao Ren +8 more
TL;DR: A direct correlation between chicken embryo fibroblast (CEF) cellular inflammatory responses and S1PR1 expression is observed and highlights the important role of S1 PR1 in inflammatory responses in NDV infection.
References
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New Mutations of CIAS1 That Are Responsible for Muckle-Wells Syndrome and Familial Cold Urticaria: A Novel Mutation Underlies Both Syndromes
Catherine Dodé,Nathalie Le Dû,Laurence Cuisset,Frank Letourneur,Jean-Marie Berthelot,Gérard Vaudour,Alain Meyrier,Richard A. Watts,G.I. David Scott,Anne Nicholls,Brigitte Granel,Camille Francès,François Garcier,Patrick Edery,Serge Boulinguez,Jean-Paul Domergues,Marc Delpech,Gilles Grateau +17 more
TL;DR: The R260W mutation was identified, thereby demonstrating that a single CIAS1 mutation may cause both MWS and FCU, and indicates that modifier genes are involved in determining either a MWS or a FCU phenotype.
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Cutting Edge: CATERPILLER: A Large Family of Mammalian Genes Containing CARD, Pyrin, Nucleotide-Binding, and Leucine-Rich Repeat Domains
TL;DR: Except for CIITA, all the predicted NBD/LRR proteins are likely ATP-binding proteins, and the genomic organization demonstrates a high degree of conservation of the NBD- and LRR-encoding exons.
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Microbiota-induced activation of epithelial IL-6 signaling links inflammasome-driven inflammation with transmissible cancer
Bo Hu,Eran Elinav,Samuel Huber,Till Strowig,Liming Hao,Anja Hafemann,Chengcheng Jin,Claudia M. Wunderlich,Thomas F. Wunderlich,Stephanie C. Eisenbarth,Richard A. Flavell +10 more
TL;DR: The results mechanistically link the altered microbiota with the pathogenesis of inflammation-induced CRC and suggest that in some conditions, microbiota components may transfer CRC susceptibility between individuals.
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Functional screening of five PYPAF family members identifies PYPAF5 as a novel regulator of NF-κB and caspase-1
Jill M. Grenier,Lin Wang,Gulam A. Manji,Waan Jeng Huang,Amal Al-Garawi,Roxanne Kelly,Adam Carlson,Sarah Merriam,Jose M. Lora,Michael J. Briskin,Peter S. DiStefano,John Bertin +11 more
TL;DR: Findings suggest that PYPAF5 functions in immune cells to coordinate the transduction of pro‐inflammatory signals to the activation of NF‐κB and pro‐caspase‐1.
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NLRX1 negatively regulates TLR-induced NF-κB signaling by targeting TRAF6 and IKK
Xiaojun Xia,Jun Cui,Helen Yicheng Wang,Liang Zhu,Satoko Matsueda,Qinfu Wang,Xiaoang Yang,Jun Hong,Zhou Songyang,Zhijian J. Chen,Rongfu Wang,Rongfu Wang +11 more
TL;DR: A previously unrecognized role for NLRX1 is identified in the negative regulation of TLR-induced NF-κB activation by dynamically interacting with TRAF6 and the IKK complex.