Journal ArticleDOI
HSP90 at the hub of protein homeostasis: emerging mechanistic insights
TLDR
Comprehensive understanding of how HSP90 functions promises not only to provide new avenues for therapeutic intervention, but to shed light on fundamental biological questions.Abstract:
Heat shock protein 90 (HSP90) is a highly conserved molecular chaperone that facilitates the maturation of a wide range of proteins (known as clients). Clients are enriched in signal transducers, including kinases and transcription factors. Therefore, HSP90 regulates diverse cellular functions and exerts marked effects on normal biology, disease and evolutionary processes. Recent structural and functional analyses have provided new insights on the transcriptional and biochemical regulation of HSP90 and the structural dynamics it uses to act on a diverse client repertoire. Comprehensive understanding of how HSP90 functions promises not only to provide new avenues for therapeutic intervention, but to shed light on fundamental biological questions.read more
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Identification of a ternary protein-complex as a therapeutic target for K-Ras-dependent colon cancer.
Xiaomei Qi,Congying Xie,Songwang Hou,Gang Li,Ning Yin,Lei Dong,Adrienne Lepp,Marla A. Chesnik,Shama P. Mirza,Aniko Szabo,Susan Tsai,Zainab Basir,Shixiu Wu,Guan Chen +13 more
TL;DR: It is demonstrated that a protein-complex activated by the Ras effector p38γ MAPK is a novel therapeutic target for K-Ras-dependent colon cancer and pharmacologically inhibition of Hsp90 or p 38γ activity disrupts the complex, decreases K-ras expression, and selectively inhibits the growth of K- Ras MT colon cancer in vitro and in vivo.
Journal ArticleDOI
Proteomic analysis of mitochondria in respiratory epithelial cells infected with human respiratory syncytial virus and functional implications for virus and cell biology.
TL;DR: The aim of this study was to quantitatively characterise the mitochondrial proteome of airway epithelial cells infected with human respiratory syncytial virus (HRSV), a major cause of paediatric illness.
Journal ArticleDOI
Comparisons of Expression Levels of Heat Shock Proteins (hsp70 and hsp90) From Anaphothrips obscurus (Thysanoptera: Thripidae) in Polymorphic Adults Exposed to Different Heat Shock Treatments.
Xue-Jie Guo,Ji-Nian Feng +1 more
TL;DR: It is shown that the expression patterns of Aohsp70 and AohSp90 are variable among different life stages and thermal stress induced different levels of expressions in macropterous and brachypterous adults.
Journal ArticleDOI
Overexpression of ESBP6 improves lactic acid resistance and production in Saccharomyces cerevisiae.
TL;DR: The results indicate that overexpression of ESBP6 provides a novel and useful tool to improve lactic acid resistance and lactic Acid production in yeast.
Journal ArticleDOI
Heat Shock Proteins in Dermatophytes: Current Advances and Perspectives
Nilce Maria Martinez-Rossi,Tiago Rinaldi Jacob,Pablo Rodrigo Sanches,Nalu T. A. Peres,Elza A. S. Lang,Maíra Pompeu Martins,Antonio Rossi +6 more
TL;DR: The quantification of the transcript levels of few genes in a pacC background helped in the development of an extended model for the regulation of the expression of the hsp genes, which supports the participation of the pH-responsive transcriptional regulator PacC in this process.
References
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Mechanism of Activation of the Raf-Erk Signaling Pathway by Oncogenic Mutations of B-Raf
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HSP90 and the chaperoning of cancer.
TL;DR: Pharmacologically 'bribing' the essential guard duty of the chaperone HSP90 (heat-shock protein of 90 kDa) seems to offer a unique anticancer strategy of considerable promise.
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Hsp90 as a capacitor for morphological evolution
TL;DR: It is reported that when Drosophila Hsp90 is mutant or pharmacologically impaired, phenotypic variation affecting nearly any adult structure is produced, with specific variants depending on the genetic background and occurring both in laboratory strains and in wild populations.
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Adapting proteostasis for disease intervention.
TL;DR: The proteostasis network is described, a set of interacting activities that maintain the health of proteome and the organism that has the potential to ameliorate some of the most challenging diseases of this era.
Journal ArticleDOI
Function and regulation of cullin-RING ubiquitin ligases.
TL;DR: This review focuses on the composition, regulation and function of cullin–RING ligases, and describes how these enzymes can be characterized by a set of general principles.