Journal ArticleDOI
HSP90 at the hub of protein homeostasis: emerging mechanistic insights
TLDR
Comprehensive understanding of how HSP90 functions promises not only to provide new avenues for therapeutic intervention, but to shed light on fundamental biological questions.Abstract:
Heat shock protein 90 (HSP90) is a highly conserved molecular chaperone that facilitates the maturation of a wide range of proteins (known as clients). Clients are enriched in signal transducers, including kinases and transcription factors. Therefore, HSP90 regulates diverse cellular functions and exerts marked effects on normal biology, disease and evolutionary processes. Recent structural and functional analyses have provided new insights on the transcriptional and biochemical regulation of HSP90 and the structural dynamics it uses to act on a diverse client repertoire. Comprehensive understanding of how HSP90 functions promises not only to provide new avenues for therapeutic intervention, but to shed light on fundamental biological questions.read more
Citations
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Journal ArticleDOI
Aspergillus fumigatus Hsp90 interacts with the main components of the cell wall integrity pathway and cooperates in heat shock and cell wall stress adaptation.
Marina Campos Rocha,Karine Minari,Karine Minari,João Henrique Tadini Marilhano Fabri,Joshua D. Kerkaert,Lisandra M. Gava,Anderson F. Cunha,Robert A. Cramer,Júlio César Borges,Iran Malavazi +9 more
TL;DR: The data suggest that the CWIP is constitutively required for A. fumigatus to cope with the temperature increase found in the mammalian lung environment, emphasising the importance of this pathway in supporting thermotolerance and cell wall integrity.
Journal ArticleDOI
Heat Shock Protein-90 Inhibition Alters Activation of Pancreatic Stellate Cells and Enhances the Efficacy of PD-1 Blockade in Pancreatic Cancer
Yuchen Zhang,Yuchen Zhang,Michael B. Ware,Mohammad Y. Zaidi,Amanda Ruggieri,Brian Olson,Hannah Komar,Matthew R. Farren,Ganji Purnachandra Nagaraju,Chao Zhang,Zhengjia Chen,Juan M. Sarmiento,Rafi Ahmed,Shishir K. Maithel,Bassel F. El-Rayes,Gregory B. Lesinski +15 more
TL;DR: It is demonstrated that Hsp90 inhibition directly affects PSC/CAF in vitro and enhances the efficacy of anti–PD-1 blockade in vivo and combined therapy with XL888 and anti- PD-1 was efficacious in C57BL/6 mice bearing syngeneic subcutaneous (Panc02) or orthotopic (KPC-Luc) tumors.
Journal ArticleDOI
Gene profiling analysis of the early effects of ablative fractional carbon dioxide laser treatment on human skin.
Jeong Eun Kim,Chong Hyun Won,Hana Bak,Garuna Kositratna,Dieter Manstein,Gian Paolo Dotto,Sung Eun Chang +6 more
TL;DR: Gene expression profiling showed that the most significantly upregulated genes in these skin samples were those encoding Wnt5a, cysteine‐rich angiogenic inducer 61 (CYR61), and heat shock protein (HSP) 90, suggesting that the induction of proteins may be the preceding event that is associated with the clinical effects of laser treatment.
Journal ArticleDOI
Unique proline-rich domain regulates the chaperone function of AIPL1.
Jing Li,Gabriel Zoldák,Thomas Kriehuber,Joanna Soroka,Franz X. Schmid,Klaus Richter,Johannes Buchner +6 more
TL;DR: The proline-rich domain decreased the affinity of AIPL1 for Hsp90, implying that this domain acts as a negative regulator of the HSp90 interaction besides being necessary for efficient binding of A IPL1 to non-native proteins.
Journal ArticleDOI
Identifying cross-category relations in gene ontology and constructing genome-specific term association networks
TL;DR: A new cross-category similarity measurement called CroGO is introduced by incorporating genome-specific gene co-function network data and it is shown that the measurement outperforms the existing algorithms.
References
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