Journal ArticleDOI
HSP90 at the hub of protein homeostasis: emerging mechanistic insights
TLDR
Comprehensive understanding of how HSP90 functions promises not only to provide new avenues for therapeutic intervention, but to shed light on fundamental biological questions.Abstract:
Heat shock protein 90 (HSP90) is a highly conserved molecular chaperone that facilitates the maturation of a wide range of proteins (known as clients). Clients are enriched in signal transducers, including kinases and transcription factors. Therefore, HSP90 regulates diverse cellular functions and exerts marked effects on normal biology, disease and evolutionary processes. Recent structural and functional analyses have provided new insights on the transcriptional and biochemical regulation of HSP90 and the structural dynamics it uses to act on a diverse client repertoire. Comprehensive understanding of how HSP90 functions promises not only to provide new avenues for therapeutic intervention, but to shed light on fundamental biological questions.read more
Citations
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Journal ArticleDOI
Hsp90 Stabilizes SIRT1 Orthologs in Mammalian Cells and C. elegans.
TL;DR: It is reported that Hsp90 is required for conformational stabilization of SIRT1 and SIR-2.1 and revealed a novel crosstalk between the proteostasis and nutrient signaling networks, which may have implications in various age related diseases.
Journal ArticleDOI
Copy number variations and polymorphisms in HSP90AB1 and risk of systemic lupus erythematosus and efficacy of glucocorticoids.
Man Zhang,Yuan-Yuan Gu,Shunwei Huang,Qiuyue Lou,Qiao-Mei Xie,Zhiwei Xu,Yang-Fan Chen,Faming Pan,Shengqian Xu,Sheng-Xiu Liu,Jin-Hui Tao,Shuang Liu,Jing Cai,Pei-Ling Chen,Long Qian,Chunhuai Wang,Chun-Mei Liang,Hailiang Huang,Hai-Feng Pan,Hong Su,Jian Cheng,Yuzhou Zhang,Wenbiao Hu,Yan-Feng Zou +23 more
TL;DR: The findings suggest that the copy number of HSP90AB1 is associated with SLE susceptibility, but copy number and polymorphisms of HDP1 may not be associated with efficacy of GCs, as well as the relationship with single‐nucleotide polymorphisms and SNPs.
Journal ArticleDOI
Systematic Analysis of the Lysine Crotonylome and Multiple Posttranslational Modification Analysis (Acetylation, Succinylation, and Crotonylation) in Candida albicans
Xiaowei Zhou,Xiaowei Zhou,Nana Song,Dongmei Li,Xiaofang Li,Xiaofang Li,Weida Liu,Weida Liu,Weida Liu +8 more
TL;DR: In this article, the authors used an antibody-enrichment approach along with LC-MS/MS to carry out a quantitative crotonylome analysis in C. albicans.
Journal ArticleDOI
Hsp90 Maintains Proteostasis of the Galactose Utilization Pathway To Prevent Cell Lethality
TL;DR: It is observed that Hsp90 influences the protein abundance of multiple Gal proteins and the efficiency of galactose utilization even after the galactOSE utilization pathway (GAL pathway) is fully induced.
Journal ArticleDOI
Integrated bioinformatic analysis of microarray data reveals shared gene signature between MDS and AML
Zhen Zhang,Lin Zhao,Xijin Wei,Qiang Guo,Xiaoxiao Zhu,Ran Wei,Xunqiang Yin,Yunhong Zhang,Bin Wang,Xia Li +9 more
TL;DR: This study has largely clarified the link between MDS and AML in terms of potential pathways, and genetic markers, which shed light on the molecular mechanisms underlying the development and transition of MDS, and facilitate the understanding of novel diagnostic, therapeutic and prognostic biomarkers.
References
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HSP90 and the chaperoning of cancer.
TL;DR: Pharmacologically 'bribing' the essential guard duty of the chaperone HSP90 (heat-shock protein of 90 kDa) seems to offer a unique anticancer strategy of considerable promise.
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Hsp90 as a capacitor for morphological evolution
TL;DR: It is reported that when Drosophila Hsp90 is mutant or pharmacologically impaired, phenotypic variation affecting nearly any adult structure is produced, with specific variants depending on the genetic background and occurring both in laboratory strains and in wild populations.
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Adapting proteostasis for disease intervention.
TL;DR: The proteostasis network is described, a set of interacting activities that maintain the health of proteome and the organism that has the potential to ameliorate some of the most challenging diseases of this era.
Journal ArticleDOI
Function and regulation of cullin-RING ubiquitin ligases.
TL;DR: This review focuses on the composition, regulation and function of cullin–RING ligases, and describes how these enzymes can be characterized by a set of general principles.