Human DNA Repair Genes
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TLDR
Modulation of DNA repair should lead to clinical applications including improvement of radiotherapy and treatment with anticancer drugs and an advanced understanding of the cellular aging process.Abstract:
Cellular DNA is subjected to continual attack, both by reactive species inside cells and by environmental agents. Toxic and mutagenic consequences are minimized by distinct pathways of repair, and 130 known human DNA repair genes are described here. Notable features presently include four enzymes that can remove uracil from DNA, seven recombination genes related to RAD51, and many recently discovered DNA polymerases that bypass damage, but only one system to remove the main DNA lesions induced by ultraviolet light. More human DNA repair genes will be found by comparison with model organisms and as common folds in three-dimensional protein structures are determined. Modulation of DNA repair should lead to clinical applications including improvement of radiotherapy and treatment with anticancer drugs and an advanced understanding of the cellular aging process.read more
Citations
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Extrapolation of Radiation-Induced Cancer Risks from Nonhuman Experimental Systems to Humans
TL;DR: An extensive review of data on radiation-induced cancer in specific major organ systems in several species of laboratory animals and extrapolation models are described that can be used under certain conditions to apply the extensive database from laboratory animal studies to the evaluation of human radiation risks.
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Genetic Variation and Exposure Related Risk Estimation: Will Toxicology Enter a New Era? DNA Repair and Cancer as a Paradigm:
TL;DR: With the vast technological and informational resources increasingly available from investments in “genomics,” toxicology and much of biological science, is faced with previously undreamed of opportunities and equally daunting challenges.
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Association analysis of ERCC5 gene polymorphisms with risk of breast cancer in Han women of northwest China
Haitao Wang,Tao Wang,Hongyun Guo,Gongjian Zhu,Suisheng Yang,Qing-Rong Hu,Yanze Du,Xiaorong Bai,Xuezhong Chen,Haixiang Su +9 more
TL;DR: It is indicated that the rs751402 in ERCC5 may affect the risk of breast cancer and show that it is associated with breast cancer characteristics in the Han population of northwest China and no significant differences were found between breast cancer patients and control subjects regarding ER CC5 rs17655 polymorphism.
Journal ArticleDOI
Relevance of XPD polymorphisms to neuroblastoma risk in Chinese children: a four-center case-control study.
Jiwen Cheng,Zhenjian Zhuo,Yijuan Xin,Pu Zhao,Weili Yang,Haixia Zhou,Jiao Zhang,Ya Gao,Jing He,Peng Li +9 more
TL;DR: It is demonstrated that XPD polymorphisms may have a cumulative effect on neuroblastoma risk and provide novel insight into the genetic underpinnings of neuroblastum and demonstrate the importance of knowing the carrier and removal status of these genes.
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Prognostic Value of Germline DNA Repair Gene Mutations in De Novo Metastatic and Castration-Sensitive Prostate Cancer
Yu Wei,Junlong Wu,Weijie Gu,Jun Wang,Guowen Lin,Xiaojian Qin,Bo Dai,Hualei Gan,Dingwei Ye,Yao Zhu +9 more
TL;DR: Results of this study suggested that positive germline DNA damage repair gene mutation (gDDRm) status predicted earlier progression to castration resistance in patients with de novo metastatic and castration-sensitive prostate cancer (mCSPC).
References
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