Human DNA Repair Genes
Reads0
Chats0
TLDR
Modulation of DNA repair should lead to clinical applications including improvement of radiotherapy and treatment with anticancer drugs and an advanced understanding of the cellular aging process.Abstract:
Cellular DNA is subjected to continual attack, both by reactive species inside cells and by environmental agents. Toxic and mutagenic consequences are minimized by distinct pathways of repair, and 130 known human DNA repair genes are described here. Notable features presently include four enzymes that can remove uracil from DNA, seven recombination genes related to RAD51, and many recently discovered DNA polymerases that bypass damage, but only one system to remove the main DNA lesions induced by ultraviolet light. More human DNA repair genes will be found by comparison with model organisms and as common folds in three-dimensional protein structures are determined. Modulation of DNA repair should lead to clinical applications including improvement of radiotherapy and treatment with anticancer drugs and an advanced understanding of the cellular aging process.read more
Citations
More filters
Journal Article
The Role of XRCC6 T-991C Functional Polymorphism in Renal Cell Carcinoma
Wen Shin Chang,Hung Lung Ke,Chia Wen Tsai,Chi-Shun Lien,Wen Ling Liao,Hui Hui Lin,Meng Hsuan Lee,Hsi Chin Wu,Chao-Hsiang Chang,Chi Cheng Chen,Hong-Zin Lee,Da Tian Bau +11 more
TL;DR: Evidence suggests that the XRCC6 T-991C genotype together with its mRNA expression are involved in the etiology of RCC and may be a marker for susceptibility to RCC in the population of Taiwan.
Journal ArticleDOI
Predicting ionizing radiation exposure using biochemically-inspired genomic machine learning.
TL;DR: Gene signatures for ionizing radiation exposure derived by machine learning have low error rates in externally validated, independent datasets, and exhibit high specificity and granularity for dose estimation.
Journal ArticleDOI
Base excision repair and the role of MUTYH
TL;DR: The mechanisms underlying the process of base excision repair are relatively well understood and are placed in context with how deterioration of this process is associated with an increased risk of malignancy.
Journal ArticleDOI
Effect of poly(ADP-ribosyl)ation inhibitors on the genotoxic effects of the boron neutron capture reaction
Nuno G. Oliveira,Matilde Castro,António Sebastião Rodrigues,Isabel C. Gonçalves,Célia Martins,José M. Toscano Rico,José Rueff +6 more
TL;DR: The results show that the inhibition of poly(ADP-ribosyl)ation does not particularly modify the genotoxicity of the BNC reaction, and that PARP inhibition together with a concomitant inhibition of DNA-PK revealed barely the same sensitizing effect as DNA- PK inhibition per se.
Journal ArticleDOI
APE1 Asp148Glu gene polymorphism and lung cancer risk: a meta-analysis.
TL;DR: In this paper, the association between the APE1 T1349G (Asp148Glu) gene polymorphisms and lung cancer risk in various populations, but their results have been inconsistent.
References
More filters
Journal ArticleDOI
Analysis of the genome sequence of the flowering plant Arabidopsis thaliana.
TL;DR: This is the first complete genome sequence of a plant and provides the foundations for more comprehensive comparison of conserved processes in all eukaryotes, identifying a wide range of plant-specific gene functions and establishing rapid systematic ways to identify genes for crop improvement.
Journal ArticleDOI
The DNA damage response: putting checkpoints in perspective
TL;DR: The inability to repair DNA damage properly in mammals leads to various disorders and enhanced rates of tumour development, and this work has shown that direct activation of DNA repair networks is needed to correct this problem.
Journal ArticleDOI
Inactivation of the DNA-Repair Gene MGMT and the Clinical Response of Gliomas to Alkylating Agents
Manel Esteller,Jesús García-Foncillas,Esther Andion,Steven N. Goodman,Oscar Fernandez Hidalgo,Vicente Vanaclocha,Stephen B. Baylin,James G. Herman +7 more
TL;DR: Methylation of the MGMT promoter in gliomas is a useful predictor of the responsiveness of the tumors to alkylating agents and an independent and stronger prognostic factor than age, stage, tumor grade, or performance status.
Journal ArticleDOI
Functional genomic analysis of C. elegans chromosome I by systematic RNA interference
Andrew G. Fraser,Ravi S. Kamath,Peder Zipperlen,Maruxa Martinez-Campos,Marc Sohrmann,Julie Ahringer +5 more
TL;DR: A reusable library of bacterial clones is constructed that will permit unlimited RNAi screens in the future and should help develop a more complete view of the relationships between the genome, gene function and the environment.
Journal ArticleDOI
Quality control by DNA repair.
Tomas Lindahl,Richard D. Wood +1 more
TL;DR: In some cases, DNA damage is not repaired but is instead bypassed by specialized DNA polymerases, and the integrity of the genetic information is compromised.