Human DNA Repair Genes
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TLDR
Modulation of DNA repair should lead to clinical applications including improvement of radiotherapy and treatment with anticancer drugs and an advanced understanding of the cellular aging process.Abstract:
Cellular DNA is subjected to continual attack, both by reactive species inside cells and by environmental agents. Toxic and mutagenic consequences are minimized by distinct pathways of repair, and 130 known human DNA repair genes are described here. Notable features presently include four enzymes that can remove uracil from DNA, seven recombination genes related to RAD51, and many recently discovered DNA polymerases that bypass damage, but only one system to remove the main DNA lesions induced by ultraviolet light. More human DNA repair genes will be found by comparison with model organisms and as common folds in three-dimensional protein structures are determined. Modulation of DNA repair should lead to clinical applications including improvement of radiotherapy and treatment with anticancer drugs and an advanced understanding of the cellular aging process.read more
Citations
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Targeting DNA Repair Proteins: A Promising Avenue for Cancer Gene Therapy
TL;DR: Several protein candidates that have been targeted by different gene therapy approaches and results obtained from in vitro and in vivo experiments are presented and discussed in the perspective of potential gene therapy clinical trials.
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XRCC1 and ERCC1 polymorphisms are related to susceptibility and survival of colorectal cancer in the Chinese population.
TL;DR: It is indicated that XRCC1 and ERCC1 polymorphisms probably affect susceptibility, chemotherapy response and survival of CRC patients, and the effects of polymorphisms on survival analysis were evaluated.
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Lack of association between XPG Asp1104His and XPF Arg415Gln polymorphism and breast cancer risk: a meta-analysis of case-control studies.
TL;DR: It is suggested that XPG Asp1104His polymorphism is not associated with increased breast cancer risk, and XPF Arg415Gln may be a low-penetrant risk factor in the Caucasian ethnicity for developing breast cancer.
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Interactions between cigarette smoking and XPC-PAT genetic polymorphism enhance bladder cancer risk
Yang Liu,Huanhuan Wang,Tianxin Lin,Quanfang Wei,Yi Zhi,Fang Yuan,Bo Song,Jin Yang,Zhiwen Chen +8 more
TL;DR: Inherited polymorphisms in the XPC gene that lead to a reduction in DNA repair capacity may increase susceptibility to bladder cancer and an elevated risk of bladder cancer was significantly associated with the gene-environment interaction in a Chinese Han population.
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The DNA Repair Gene APE1 T1349G Polymorphism and Risk of Gastric Cancer in a Chinese Population
TL;DR: The APE1 T1349G polymorphism may be a marker for the development of gastric cancer in the Chinese population and further analyses revealed that the variant genotypes were associated with an increased risk for diffuse-type, low depth of tumor infiltration (T1 and T2), and lymph node metastasis Gastric cancer.
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