Human DNA Repair Genes
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TLDR
Modulation of DNA repair should lead to clinical applications including improvement of radiotherapy and treatment with anticancer drugs and an advanced understanding of the cellular aging process.Abstract:
Cellular DNA is subjected to continual attack, both by reactive species inside cells and by environmental agents. Toxic and mutagenic consequences are minimized by distinct pathways of repair, and 130 known human DNA repair genes are described here. Notable features presently include four enzymes that can remove uracil from DNA, seven recombination genes related to RAD51, and many recently discovered DNA polymerases that bypass damage, but only one system to remove the main DNA lesions induced by ultraviolet light. More human DNA repair genes will be found by comparison with model organisms and as common folds in three-dimensional protein structures are determined. Modulation of DNA repair should lead to clinical applications including improvement of radiotherapy and treatment with anticancer drugs and an advanced understanding of the cellular aging process.read more
Citations
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Bi-allelic alterations in DNA repair genes underpin homologous recombination DNA repair defects in breast cancer
Robert W. Mutter,Robert W. Mutter,Nadeem Riaz,Charlotte K.Y. Ng,Rob Delsite,Salvatore Piscuoglio,Marcia Edelweiss,Luciano G. Martelotto,Rita A. Sakr,Tari A. King,Dilip Giri,Maria Drobnjak,Edi Brogi,Ranjit S. Bindra,Ranjit S. Bindra,Giana Bernheim,Raymond S. Lim,Pedro Blecua,Alexis Desrichard,Daniel S. Higginson,Russell Towers,Ruomu Jiang,William Lee,Britta Weigelt,Jorge S. Reis-Filho,Simon N. Powell +25 more
TL;DR: The findings indicate the importance of a comprehensive genetic assessment of bi‐allelic alterations in the HR pathway to deliver a precision medicine‐based approach to select patients for therapies targeting tumour‐specific DNA repair defects.
Journal ArticleDOI
Nucleotide-excision repair and prostate cancer risk
TL;DR: This review focuses on the association between CaP and nucleotide excision repair (NER), because some of the DNA adducts generated by CaP-related carcinogens are removed by the NER pathway, and previous data showed a significant association between lower NER capacity (NERC) and CaP risk.
Journal ArticleDOI
The association between OGG1 Ser326Cys polymorphism and lung cancer susceptibility: a meta-analysis of 27 studies
Weixun Duan,Rui-Xi Hua,Wei Yi,Li-Jun Shen,Zhenxiao Jin,Yuhong Zhao,Dinghua Yi,Wensheng Chen,Shiqiang Yu +8 more
TL;DR: Solid statistical evidence is established for an association between the OGG1 Cys/Cys genotype and lung cancer risk, particularly for studies with large sample size and adenocarcinoma, but this association warrants additional validation in larger and well designed studies.
Journal ArticleDOI
Genetic variation in base excision repair pathway genes, pesticide exposure, and prostate cancer risk.
Kathryn Hughes Barry,Stella Koutros,Sonja I. Berndt,Gabriella Andreotti,Jane A. Hoppin,Dale P. Sandler,Laurie Burdette,Meredith Yeager,Laura E. Beane Freeman,Jay H. Lubin,Xiaomei Ma,Tongzhang Zheng,Michael C. R. Alavanja +12 more
TL;DR: A role of BER genetic variation in pesticide-associated prostate cancer risk is suggested in a nested case–control study of white Agricultural Health Study pesticide applicators.
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Computational prediction of the effects of non-synonymous single nucleotide polymorphisms in human DNA repair genes
TL;DR: This work provides a comprehensive, updated list of all validated nsSNPs from dbSNP (public database of human single nucleotide polymorphisms at National Center for Biotechnology Information, USA) located in human DNA repair genes, and characterized each polymorphism in terms of different functional properties.
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