"Human, mouse and dog bone marrow show similar mesenchymal stromal cells within a distinctive microenvironment".
Berenice Meza-León,Dita Gratzinger,Alicia G. Aguilar-Navarro,Fany G. Juárez-Aguilar,Vivienne I. Rebel,Emina Torlakovic,Emina Torlakovic,Louise E. Purton,Louise E. Purton,Elisa Dorantes-Acosta,Argelia Escobar-Sánchez,John E. Dick,Eugenia Flores-Figueroa,Eugenia Flores-Figueroa +13 more
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TLDR
In this article, the authors conducted a systematic histopathological comparison of mouse, human, and dog BMSCs within their bone marrow architecture and microenvironment and found that mouse bone marrow had higher cellularity and megakaryocyte content.About:
This article is published in Experimental Hematology.The article was published on 2021-07-03 and is currently open access. It has received 3 citations till now. The article focuses on the topics: Hematopoietic stem cell & Bone marrow.read more
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Dynamic Changes of the Bone Marrow Niche: Mesenchymal Stromal Cells and Their Progeny During Aging and Leukemia.
Kevin Woods,Borhane Guezguez +1 more
TL;DR: In this article, a review of the BM-MSC biology through single-cell identification of hierarchical subsets with distinct functionalities and transcriptional profiles is presented, and the contribution of mesenchymal stromal cells and their osteo-adipo progeny in modulating the complex direct cell-to-cell or indirect soluble factors-mediated interactions of BM HSC niche during homeostasis, aging and myeloid malignancies.
Journal ArticleDOI
Monitoring longitudinal disease progression in a novel murine Kit tumor model using high-field MRI
Markus J. Kraiger,Tanja Klein-Rodewald,Birgit Rathkolb,Julia Calzada-Wack,Adrian Sanz-Moreno,Helmut Fuchs,Eckhard Wolf,Valerie Gailus-Durner,Martin Hrabé de Angelis +8 more
TL;DR: In this paper , the authors applied magnetic resonance imaging (MRI) to characterize the clinical picture of a novel N-ethyl-N-nitrosourea-induced Kit -mutant mouse in vivo.
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Single-cell RNA sequencing of human non-hematopoietic bone marrow cells reveals a unique set of inter-species conserved biomarkers for native mesenchymal stromal cells
TL;DR: In this article , a taxonomy of BM mesenchymal stem/stromal cells (MSCs) was defined using single-cell RNA sequencing (scRNA-seq) data.
References
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Journal ArticleDOI
Of mice and not men: differences between mouse and human immunology
TL;DR: Known discrepancies in both innate and adaptive immunity are outlined, including balance of leukocyte subsets, defensins, Toll receptors, inducible NO synthase, the NK inhibitory receptor families Ly49 and KIR, FcR, Ig subsets andChemokine and chemokine receptor expression.
Journal ArticleDOI
Mesenchymal and haematopoietic stem cells form a unique bone marrow niche
Simón Méndez-Ferrer,Tatyana V. Michurina,Francesca Ferraro,Amin R. Mazloom,Ben D. MacArthur,Ben D. MacArthur,Sergio A. Lira,David T. Scadden,Avi Ma'ayan,Grigori Enikolopov,Paul S. Frenette,Paul S. Frenette +11 more
TL;DR: It is demonstrated that mesenchymal stem cells (MSCs), identified using nestin expression, constitute an essential HSC niche component and are indicative of a unique niche in the bone marrow made of heterotypic stem-cell pairs.
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Self-Renewing Osteoprogenitors in Bone Marrow Sinusoids Can Organize a Hematopoietic Microenvironment
Benedetto Sacchetti,Alessia Funari,Stefano Michienzi,Silvia Di Cesare,Stefania Piersanti,Isabella Saggio,Isabella Saggio,Enrico Tagliafico,Stefano Ferrari,Pamela Gehron Robey,Mara Riminucci,Paolo Bianco +11 more
TL;DR: It is shown that MCAM/CD146-expressing, subendothelial cells in human BM stroma are capable of transferring, upon transplantation, the HME to heterotopic sites, coincident with the establishment of identical subendOThelial cells within a miniature bone organ.
Journal ArticleDOI
The bone marrow niche for haematopoietic stem cells
TL;DR: The haematopoietic stem cell niche remains incompletely defined and beset by competing models, and outstanding questions concern the cellular complexity of the niche, the role of the endosteum and functional heterogeneity among perivascular microenvironments.
Journal ArticleDOI
Haematopoietic stem cells and early lymphoid progenitors occupy distinct bone marrow niches
Lei Ding,Sean J. Morrison +1 more
TL;DR: Assessment of the physiological sources of the chemokine CXCL12 for HSC and restricted progenitor maintenance shows that Cxcl12 was primarily expressed by perivascular stromal cells and, at lower levels, by endothelial cells, osteoblasts and some haematopoietic cells.