Hydrogels derived from demineralized and decellularized bone extracellular matrix
Michael J. Sawkins,W. Bowen,P. Dhadda,H. Markides,Laura E. Sidney,Adam J. Taylor,Felicity R. A. J. Rose,Stephen F. Badylak,Kevin M. Shakesheff,Lisa J. White +9 more
TLDR
In this paper, the authors applied a stringent decellularization process to demineralized bone matrix (DBM), prepared from bovine bone, and characterized the structure and composition of the resulting ECM materials and DBM itself.About:
This article is published in Acta Biomaterialia.The article was published on 2013-08-01 and is currently open access. It has received 228 citations till now. The article focuses on the topics: Self-healing hydrogels & Decellularization.read more
Citations
More filters
Journal ArticleDOI
Advancing biomaterials of human origin for tissue engineering
Fa-Ming Chen,Xiaohua Liu +1 more
TL;DR: An exploration of the structural, mechanical, biochemical and biological information present in native human tissue for bioengineering applications is focused on to provide inspiration for the design of future biomaterials.
Journal ArticleDOI
Extracellular matrix hydrogels from decellularized tissues: Structure and function.
Lindsey T. Saldin,Madeline C. Cramer,Sachin Velankar,Lisa J. White,Lisa J. White,Stephen F. Badylak +5 more
TL;DR: The present manuscript represents a review of ECM hydrogels and attempts to identify structure-function relationships that influence the tissue remodeling outcomes and gaps in the understanding thereof.
Journal ArticleDOI
Tissue Engineered Bio-Blood-Vessels Constructed Using a Tissue-Specific Bioink and 3D Coaxial Cell Printing Technique: A Novel Therapy for Ischemic Disease
Ge Gao,Jun Hee Lee,Jinah Jang,Dong Han Lee,Jeong-Sik Kong,Byoung Soo Kim,Yeong-Jin Choi,Woong Bi Jang,Young Joon Hong,Sang-Mo Kwon,Dong-Woo Cho +10 more
TL;DR: The outcomes suggest that the 3D‐printed ECM‐mediated cell/drug implantation can be a new therapeutic approach for the treatment of various ischemic diseases.
Journal ArticleDOI
Extracellular matrix hydrogel therapies: In vivo applications and development.
TL;DR: This review will focus on in vivo applications of ECM hydrogels and functional outcomes in disease models, as well as discuss considerations for clinical translation.
Journal ArticleDOI
Tissue engineering by decellularization and 3D bioprinting
Elena Garreta,Roger Oria,Carolina Tarantino,Mateu Pla-Roca,Patrícia Rezende do Prado,Francisco Fernández-Avilés,Josep M. Campistol,Josep Samitier,Nuria Montserrat +8 more
TL;DR: Recent progress in decellularization/re cellularization and 3D bioprinting technologies are reviewed, aiming to fabricate autologous tissue grafts and organs with an impact in regenerative medicine.
References
More filters
Journal ArticleDOI
The determination of hydroxyproline in tissue and protein samples containing small proportions of this imino acid.
TL;DR: Method has been applied to a study of hydroxyproline distribution in cell particulates, tissue fluids, and purified plant and animal proteins, and significant amounts of hydroXYproline were found in crystalline preparations of pepsin, elastase.
Journal ArticleDOI
Burden of major musculoskeletal conditions
TL;DR: The burden of four major musculoskeletal conditions: osteoarthritis, rheumatoid arthritis, osteoporosis, and low back pain, which affects nearly everyone at some point in time and about 4-33% of the population at any given point is described.
Journal ArticleDOI
An overview of tissue and whole organ decellularization processes.
TL;DR: Tissue decellularization with preservation of ECM integrity and bioactivity can be optimized by making educated decisions regarding the agents and techniques utilized during processing.
Journal ArticleDOI
Organ reengineering through development of a transplantable recellularized liver graft using decellularized liver matrix
Basak E. Uygun,Alejandro Soto-Gutierrez,Alejandro Soto-Gutierrez,Hiroshi Yagi,Hiroshi Yagi,Maria Louisa Izamis,Maria Angela Guzzardi,Maria Angela Guzzardi,Carley Shulman,Jack M. Milwid,Naoya Kobayashi,Arno W. Tilles,Francois Berthiaume,Francois Berthiaume,Martin Hertl,Yaakov Nahmias,Yaakov Nahmias,Martin L. Yarmush,Martin L. Yarmush,Korkut Uygun +19 more
TL;DR: A novel approach to generate transplantable liver grafts using decellularized liver matrix that preserves the structural and functional characteristics of the native microvascular network, allowing efficient recellularization of the liver matrix with adult hepatocytes and subsequent perfusion for in vitro culture.
Journal ArticleDOI
Tissue-Engineered Lungs for in Vivo Implantation
Thomas Petersen,Elizabeth A. Calle,Liping Zhao,Eun Jung Lee,Liqiong Gui,Micha Sam Brickman Raredon,Kseniya Gavrilov,Tai Yi,Zhen W. Zhuang,Christopher K. Breuer,Erica L. Herzog,Laura E. Niklason +11 more
TL;DR: Treating lungs from adult rats using a procedure that removes cellular components but leaves behind a scaffold of extracellular matrix suggests that repopulation of lung matrix is a viable strategy for lung regeneration.