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Journal ArticleDOI

IAGG Workshop : Health promotion program on prevention of late onset dementia

TLDR
Thirty world specialists coming from Europe, North America, Asia, South America, Africa and Australia, shared their experience on methods and results of large epidemiological interventions to reduce incidents of dementia or delay its on-set.
Abstract
IAGG, WHO, and SFGG organized a international workshop on Health promotion programs on prevention of late on-set dementia. Thirty world specialists coming from Europe, North America, Asia, South America, Africa and Australia, shared their experience on methods and results of large epidemiological interventions to reduce incidents of dementia or delay its on-set. Chaired by Laura FRATIGLIONI, an expert in Epidemiological studies on dementia issues, the workshop gave opportunity for discussions and controversies about the state-of-the-art. Based on different national and international trials (ADAPT, MAPT, FINGER, GUDIAGE, GEM etc) the questions remained opened for different aspects of methodology, the choice of domain or multi domain intervention, the choice and the definition of the target populations, the best age of candidates, the issues related to the discrepancy between late effects, and interventions' duration. We are please to publish in the Journal, the presentations presented to this workshop. These publications will complete previously task force published in the journal in the last two years on methodological issues for Alzheimer's trials including end point, biomarkers, and the experience of past therapeutic trials.

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Towards a comprehensive public health response to population ageing

TL;DR: Older people can be valuable economic, social, cultural, and familial resources, but are also likely to be associated with a shrinking workforce and higher demand for health care, social care, and social pensions.
Journal ArticleDOI

Dementia prevention: current epidemiological evidence and future perspective

TL;DR: There is sufficient evidence that vascular risk factors significantly contribute to the expression and progression of cognitive decline but that active engagement in social, physical, and mentally stimulating activities may delay the onset of dementia, but these findings need to be confirmed by randomized controlled trials (RCTs).
Journal ArticleDOI

Validity of dementia and Alzheimer's disease diagnoses in Finnish national registers.

TL;DR: In this paper, the authors investigated dementia and Alzheimer disease (AD) diagnoses in three national registers in Finland: the Hospital Discharge Register (HDR), the Drug Reimbursement Register, and the Causes of Death Register (CDR).
References
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Journal ArticleDOI

Projections of Alzheimer's disease in the United States and the public health impact of delaying disease onset.

TL;DR: If interventions could delay onset of the disease by 2 years, after 50 years there would be nearly 2 million fewer cases than projected; if onset could be delayed by 1 year, thereWould be nearly 800,000 fewer prevalent cases.
Journal ArticleDOI

Effect of physical activity on cognitive function in older adults at risk for Alzheimer disease: a randomized trial.

TL;DR: In this study of adults with subjective memory impairment, a 6-month program of physical activity provided a modest improvement in cognition over an 18-month follow-up period.
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Long-term effects of cognitive training on everyday functional outcomes in older adults

TL;DR: Cognitive training resulted in improved cognitive abilities specific to the abilities trained that continued 5 years after the initiation of the intervention, and booster training for the speed of processing group showed a significant effect on the performance-based functional measure of everyday speed ofprocessing.
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Evidence-Based Public Health: Moving Beyond Randomized Trials

TL;DR: There is an urgent need to develop evaluation standards and protocols for use in circumstances where RCTs are not appropriate, and both the internal and external validity of RCT findings can be greatly enhanced by observational studies using adequacy or plausibility designs.
Journal ArticleDOI

Public health. Implementation science.

TL;DR: The scale-up of male circumcision and prophylactic anti-retroviral therapy and replacement feeding have worked well in hospitals and clinics, but increasing coverage in rural areas may require testing of novel approaches, such as self-administration of drugs.
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