Identification of an Intestinal Microbiota Signature Associated With Severity of Irritable Bowel Syndrome
Julien Tap,Muriel Derrien,Hans Törnblom,Rémi Brazeilles,Stéphanie Cools-Portier,Joël Doré,Stine Störsrud,Boris Le Nevé,Lena Öhman,Lena Öhman,Magnus Simren,Magnus Simren +11 more
TLDR
IBS symptom severity is found to be associated negatively with microbial richness, exhaled CH4, presence of methanogens, and enterotypes enriched with Clostridiales or Prevotella species.About:
This article is published in Gastroenterology.The article was published on 2017-01-01 and is currently open access. It has received 445 citations till now. The article focuses on the topics: Irritable bowel syndrome & Outpatient clinic.read more
Citations
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Journal ArticleDOI
The Brain-Gut-Microbiome Axis.
TL;DR: A systems biological model is proposed that posits circular communication loops amid the brain, gut, and gut microbiome, and in which perturbation at any level can propagate dysregulation throughout the circuit.
Journal ArticleDOI
Gut Microbiota in Patients With Irritable Bowel Syndrome-A Systematic Review.
Rapat Pittayanon,Rapat Pittayanon,Jennifer T. Lau,Yuhong Yuan,Grigorios I. Leontiadis,Frances Tse,Michael G. Surette,Paul Moayyedi +7 more
TL;DR: In a systematic review, specific bacteria associated with microbiomes of patients with IBS vs controls were identified and studies are needed to determine whether these microbes are a product or cause of IBS.
Journal ArticleDOI
Systematic review with meta-analysis: the efficacy of prebiotics, probiotics, synbiotics and antibiotics in irritable bowel syndrome.
Alexander C. Ford,Alexander C. Ford,Lucinda A. Harris,Brian E. Lacy,Eamonn Martin Quigley,Paul Moayyedi +5 more
TL;DR: It is necessary to select patients suitable for vaginal or laparoscopic mesh placement for IBS preoperatively on the basis of prior history and once they provide informed consent for surgery.
Journal ArticleDOI
Impact of commonly used drugs on the composition and metabolic function of the gut microbiota
Arnau Vich Vila,Valerie Collij,Serena Sanna,Trishla Sinha,Floris Imhann,Arno R. Bourgonje,Zlatan Mujagic,Daisy Jonkers,Ad A.M. Masclee,Jingyuan Fu,Alexander Kurilshikov,Cisca Wijmenga,Alexandra Zhernakova,Rinse K. Weersma +13 more
TL;DR: The impact of 41 commonly used medications on the taxonomic structures, metabolic potential and resistome of the gut microbiome is studied, underscoring the importance of correcting for multiple drug use in microbiome studies.
Journal ArticleDOI
Gut microbiota composition and functional changes in inflammatory bowel disease and irritable bowel syndrome
Arnau Vich Vila,Floris Imhann,Valerie Collij,Soesma A Jankipersadsing,Thomas Gurry,Thomas Gurry,Zlatan Mujagic,Alexander Kurilshikov,Marc Jan Bonder,Xiaofang Jiang,Xiaofang Jiang,Ettje F. Tigchelaar,Jackie A M Dekens,Vera Peters,Michiel Voskuil,Marijn C. Visschedijk,Hendrik M. van Dullemen,Daniel Keszthelyi,Morris A. Swertz,Lude Franke,Rudi Alberts,Eleonora A. M. Festen,Gerard Dijkstra,Ad A.M. Masclee,Marten H. Hofker,Ramnik J. Xavier,Ramnik J. Xavier,Eric J. Alm,Eric J. Alm,Jingyuan Fu,Cisca Wijmenga,Daisy Jonkers,Alexandra Zhernakova,Rinse K. Weersma +33 more
TL;DR: A case-control analysis using shotgun metagenomic sequencing of stool samples from 1792 individuals with IBD and IBS compared with control individuals in the general population was able to use gut microbiota composition differences to distinguish patients with I BD from those with IBS.
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