Identifying adult asthma phenotypes using a clustering approach
Valérie Siroux,Xavier Basagaña,Anne Boudier,Isabelle Pin,J. Garcia-Aymerich,Aurélien Vesin,Rémy Slama,Deborah Jarvis,Josep M. Antó,Francine Kauffmann,Jordi Sunyer +10 more
TLDR
The aim of the present study was to identify distinct asthma phenotypes by applying latent class analysis (LCA), a model-based clustering method, to two large epidemiological studies, and revealed four distinct asthma Phenotypes in each sample.Abstract:
There is a need to improve asthma characterisation by integrating multiple aspects of the disease. The aim of the present study was to identify distinct asthma phenotypes by applying latent class analysis (LCA), a model-based clustering method, to two large epidemiological studies. Adults with asthma who participated in the follow-up of the Epidemiological Study on the Genetics and Environment of Asthma (EGEA2) (n = 641) and the European Community Respiratory Health Survey (ECRHSII) (n = 1,895) were included. 19 variables covering personal characteristics, asthma symptoms, exacerbations and treatment, age of asthma onset, allergic characteristics, lung function and airway hyperresponsiveness were considered in the LCA. Four asthma phenotypes were distinguished by the LCA in each sample. Two phenotypes were similar in EGEA2 and ECRHSII: active treated allergic childhood-onset asthma and active treated adult-onset asthma. The other two phenotypes were composed of subjects with inactive or mild untreated asthma, who differed by atopy status and age of asthma onset (childhood or adulthood). The phenotypes clearly discriminated populations in terms of quality of life, and blood eosinophil and neutrophil counts. The LCAs revealed four distinct asthma phenotypes in each sample. Considering these more homogeneous phenotypes in future studies may lead to a better identification of risk factors for asthma.read more
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Asthma phenotypes: the evolution from clinical to molecular approaches
TL;DR: Ongoing studies of large-scale, molecularly and genetically focused and extensively clinically characterized cohorts of asthma should enhance the ability to molecularly understand these phenotypes and lead to more targeted and personalized approaches to asthma therapy.
Journal ArticleDOI
Sputum neutrophil counts are associated with more severe asthma phenotypes using cluster analysis
Wendy C. Moore,Annette T. Hastie,Xingnan Li,Huashi Li,William W. Busse,Nizar N. Jarjour,Sally E. Wenzel,Stephen P. Peters,Deborah A. Meyers,Eugene R. Bleecker +9 more
TL;DR: In this paper, a multivariate approach identified four asthma subphenotypes representing the severity spectrum from mild-to-moderate allergic asthma with minimal or eosinophil-predominant sputum inflammation to moderate to severe asthma with neutrophil-or mixed granulocytic inflammation.
Journal ArticleDOI
Asthma phenotypes and the use of biologic medications in asthma and allergic disease: The next steps toward personalized care
Merritt L. Fajt,Sally E. Wenzel +1 more
TL;DR: It is concluded that further refinement of type 2 therapies to specific type 2 phenotypes and novel approaches for patients without type 2 inflammation are needed for asthma and allergic disease treatment.
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Severe asthma: from characteristics to phenotypes to endotypes.
TL;DR: The identification of these endotypes, either by matching biology, genetics and therapeutic responses to therapy with clinically or statistically defined phenotypes or through unbiased genetic and genomic approaches, remains limited.
Journal ArticleDOI
Untangling asthma phenotypes and endotypes
TL;DR: Whether newly defined asthma endotypes predict the individual course of asthma has to be validated in longitudinal studies and the identification of corresponding molecular biomarkers for individual pathogenic mechanism underlying phenotypes or subgroups within a phenotype is important.
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Identification of Asthma Phenotypes Using Cluster Analysis in the Severe Asthma Research Program
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